PMID- 37350417
OWN - NLM
STAT- MEDLINE
DCOM- 20240101
LR  - 20240101
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 34
IP  - 1
DP  - 2024 Jan
TI  - Neurogenic dry eye associated with intravitreal injection of anti-VEGF agents.
PG  - NP35-NP40
LID - 10.1177/11206721231177475 [doi]
AB  - PURPOSE: To report a case of neurogenic dry eye (NDE) that developed after 
      intravitreal ranibizumab injection (IVR). CASE REPORT: A 71-year-old woman had a 
      history of cataract phacoemulsification and intraocular lens (IOL) implantation, 
      Nd:YAG laser posterior capsulotomy and femtosecond laser-assisted laser in situ 
      keratomileusis (FS-LASIK). Aneurysmal dilatation of the inferior temporal retina 
      was found in the left fundus, which was diagnosed as retinal aneurysm, and 
      intravitreal ranibizumab injection was administered. Dry eye was found in the 
      left eye after the first injection. After the second injection, the patient 
      developed severe dry eye with left eye dryness, photophobia, irritation, and 
      blurred vision. The tear film breakup time (TBUT) value was 3 s, the Schirmer 
      test value was 2 mm/5 min, corneal fluorescein staining (CFS) showed diffuse 
      patellar staining of the corneal epithelium with a staining area of >50% and 
      irregular staining at the edge of the corneal flap, and the corneal touch 
      threshold value in the filament length was 1.5 cm in the left eye. CONCLUSIONS: 
      Patients with a history of intraocular lens implantation, Nd:YAG laser posterior 
      capsulotomy, and femtosecond laser-assisted laser in situ keratomileusis surgery 
      may have increased drug permeability due to an increased concentration of 
      anti-VEGF drugs in the aqueous layer and thinning of the stromal layer of the 
      cornea. The corneal subepithelial nerve repair mechanism was destroyed, causing 
      neurogenic dry eye.
FAU - Lin, Shu-Hua
AU  - Lin SH
AD  - Department of Ophthalmology, Fuyang People's Hospital of Anhui Medical 
      University, Fuyang, Anhui, China.
AD  - Department of Ophthalmology, Affiliated Hospital of Yanbian University, Yanji, 
      Jilin, China.
FAU - Fang, Yu-Hui
AU  - Fang YH
AD  - Department of Dermatology, Fuyang People's Hospital of Anhui Medical University, 
      Fuyang, Anhui, China.
FAU - Jia, Fa-Li
AU  - Jia FL
AD  - Department of Ophthalmology, Affiliated Hospital of Yanbian University, Yanji, 
      Jilin, China.
FAU - Li, Ying-Jun
AU  - Li YJ
AUID- ORCID: 0000-0002-7704-6651
AD  - Department of Ophthalmology, Fuyang People's Hospital of Anhui Medical 
      University, Fuyang, Anhui, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20230623
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - ZL1R02VT79 (Ranibizumab)
SB  - IM
MH  - Female
MH  - Humans
MH  - Aged
MH  - Intravitreal Injections
MH  - Ranibizumab
MH  - Cornea
MH  - *Keratomileusis, Laser In Situ
MH  - *Dry Eye Syndromes/chemically induced/diagnosis
OTO - NOTNLM
OT  - femtosecond laser-assisted laser in situ keratomileusis
OT  - intravitreal ranibizumab injection
OT  - nd:YAG laser posterior capsulotomy
OT  - neurogenic dry eye
OT  - retinal aneurysm
COIS- Declaration of conflicting interestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/06/23 13:07
MHDA- 2024/01/02 11:46
CRDT- 2023/06/23 07:02
PHST- 2024/01/02 11:46 [medline]
PHST- 2023/06/23 13:07 [pubmed]
PHST- 2023/06/23 07:02 [entrez]
AID - 10.1177/11206721231177475 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2024 Jan;34(1):NP35-NP40. doi: 10.1177/11206721231177475. Epub 
      2023 Jun 23.