PMID- 37350565
OWN - NLM
STAT- MEDLINE
DCOM- 20230721
LR  - 20230721
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 14
IP  - 14
DP  - 2023 Jul 17
TI  - Effect of coenzyme Q10 on cardiac function and survival in heart failure: an 
      overview of systematic reviews and meta-analyses.
PG  - 6302-6311
LID - 10.1039/d3fo01255g [doi]
AB  - Heart failure (HF) is associated with a deficiency in blood levels of coenzyme 
      Q10 (CoQ10), and its supplementation has been proposed. The aim of this 
      systematic review was to synthesise the available evidence on the effects of 
      CoQ10 on cardiac function and quality of life in HF. A systematic search of 
      Medline, Scopus, Web of Science and the Cochrane Library was conducted from 
      inception until March 2023. Meta-analyses measuring the effect of CoQ10 on 
      cardiac function [i.e., ejection fraction (EF), cardiac output (CO), cardiac 
      index (CI), stroke volume (SV)], quality of life [i.e., mortality, exercise 
      capacity, and New York Heart Association (NYHA) classification], and CoQ10 levels 
      in HF were included. Ten meta-analyses met the inclusion criteria. CoQ10 had an 
      effect on EF in 6 of the 9 studies, with an increase of 1.77% (0.10, 3.44) to 
      3.81% (1.22, 6.40), while it had an effect on CO, CI and SV in one of the two 
      studies. Moreover, CoQ10 did not improve exercise capacity and only one study 
      showed an effect on NYHA classification, while there was a risk ratio (RR) of 
      0.69 (0.50, 0.95) to 0.58 (0.35, 0.95) in favour of CoQ10 for mortality and a RR 
      of 0.62 (0.49, 0.78) for hospitalisations. Finally, CoQ10 levels were found to 
      increase by 1.40 mug mL(-1) in all studies. CoQ10 showed a possible beneficial 
      effect on heart function, which was associated with a reduction in mortality and 
      hospitalisations. However, more research is needed into the conditions that may 
      optimise CoQ10 therapy.
FAU - Alarcon-Vieco, Eva
AU  - Alarcon-Vieco E
AD  - Health and Social Research Center, Universidad de Castilla - La, Mancha, 16071, 
      Cuenca, Spain. eva.alarcon@alu.uclm.es.
FAU - Martinez-Garcia, Irene
AU  - Martinez-Garcia I
AUID- ORCID: 0000-0001-7835-6953
AD  - Health and Social Research Center, Universidad de Castilla - La, Mancha, 16071, 
      Cuenca, Spain. eva.alarcon@alu.uclm.es.
FAU - Sequi-Dominguez, Irene
AU  - Sequi-Dominguez I
AUID- ORCID: 0000-0001-8981-4331
AD  - Health and Social Research Center, Universidad de Castilla - La, Mancha, 16071, 
      Cuenca, Spain. eva.alarcon@alu.uclm.es.
FAU - Rodriguez-Gutierrez, Eva
AU  - Rodriguez-Gutierrez E
AD  - Health and Social Research Center, Universidad de Castilla - La, Mancha, 16071, 
      Cuenca, Spain. eva.alarcon@alu.uclm.es.
FAU - Moreno-Herraiz, Nerea
AU  - Moreno-Herraiz N
AD  - Health and Social Research Center, Universidad de Castilla - La, Mancha, 16071, 
      Cuenca, Spain. eva.alarcon@alu.uclm.es.
FAU - Pascual-Morena, Carlos
AU  - Pascual-Morena C
AD  - Health and Social Research Center, Universidad de Castilla - La, Mancha, 16071, 
      Cuenca, Spain. eva.alarcon@alu.uclm.es.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230717
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - EJ27X76M46 (coenzyme Q10)
SB  - IM
MH  - Humans
MH  - *Heart Failure/drug therapy
MH  - *Quality of Life
MH  - Stroke Volume
MH  - Systematic Reviews as Topic
MH  - Meta-Analysis as Topic
EDAT- 2023/06/23 13:07
MHDA- 2023/07/19 06:43
CRDT- 2023/06/23 08:52
PHST- 2023/07/19 06:43 [medline]
PHST- 2023/06/23 13:07 [pubmed]
PHST- 2023/06/23 08:52 [entrez]
AID - 10.1039/d3fo01255g [doi]
PST - epublish
SO  - Food Funct. 2023 Jul 17;14(14):6302-6311. doi: 10.1039/d3fo01255g.