PMID- 37351057
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230701
IS  - 2008-7802 (Print)
IS  - 2008-8213 (Electronic)
IS  - 2008-7802 (Linking)
VI  - 14
DP  - 2023
TI  - Urtica dioica (Gazaneh) distillate restores glucose metabolism in diabetic rats.
PG  - 68
LID - 10.4103/ijpvm.ijpvm_293_21 [doi]
LID - 68
AB  - BACKGROUND: Diabetes has become an important health problem in the world. Natural 
      agents, with antidiabetic property, are potential candidates for improving 
      diabetes. Urtica Dioica Distillate (UDD) or Araghe Gazaneh is widely used for the 
      treatment of diabetes as per traditional medicine. Despite the tremendous use of 
      UDD as an antidiabetic compound in folk medicine, the antidiabetic effects of UDD 
      has been neglected by medical scientists. In this study, we aimed to evaluate the 
      effects of UDD on the glucose metabolism in diabetic rats. METHODS: A total of 24 
      male rats were divided equally into four groups, two treatment and two control 
      groups, each containing normal or Streptozotocin (STZ)-induced diabetic rats. 
      During 4 weeks, control and treatment rats received water or UDD, respectively. 
      Fasting blood sugar (FBS), HbA1c, serum creatinine, blood urea nitrogen, and 
      specific activities of hepatic enzymes including glucokinase (GK), hexokinase 
      (HK), glucose-6-phosphate dehydrogenase (G6PD), and muscle glucose transporter 
      type 4 (GLUT4) and liver phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels 
      were measured. RESULTS: FBS and HbA1c increased in diabetic groups. Treatment 
      with UDD significantly lowered FBS and prevented weight loss. Decreased FBS level 
      was associated with higher activity levels of GK and HK in UDD-treated diabetic 
      rats. G6PD-specific activity decreased in diabetic control rats compared to 
      nondiabetic ones, but UDD treatment improved it to the normal levels. A 
      significant decrease in the expression level of GLUT4 was observed in diabetic 
      control rats compared to nondiabetic ones, but UDD increased it to the normal 
      levels. CONCLUSIONS: These findings suggest that UDD might exert therapeutic 
      effects against diabetes by improving glucose metabolism and can be used as an 
      alternative or complementary medicine for the treatment of diabetic patients.
CI  - Copyright: (c) 2023 International Journal of Preventive Medicine.
FAU - Zamani-Garmsiri, Fahimeh
AU  - Zamani-Garmsiri F
AD  - Department of Biochemistry, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Akmali, Masoumeh
AU  - Akmali M
AD  - Department of Biochemistry, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Gohari, Ali
AU  - Gohari A
AD  - Department of Biochemistry, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Zal, Fatemeh
AU  - Zal F
AD  - Department of Biochemistry, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Seghatoleslam, Atefeh
AU  - Seghatoleslam A
AD  - Department of Biochemistry, School of Medicine, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230527
PL  - Iran
TA  - Int J Prev Med
JT  - International journal of preventive medicine
JID - 101535380
PMC - PMC10284253
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Urtica Dioica distillate
OT  - diabetic rats
OT  - hepatic enzymes
COIS- There are no conflicts of interest.
EDAT- 2023/06/23 13:07
MHDA- 2023/06/23 13:08
PMCR- 2023/05/27
CRDT- 2023/06/23 10:28
PHST- 2021/06/27 00:00 [received]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2023/06/23 13:08 [medline]
PHST- 2023/06/23 13:07 [pubmed]
PHST- 2023/06/23 10:28 [entrez]
PHST- 2023/05/27 00:00 [pmc-release]
AID - IJPVM-14-68 [pii]
AID - 10.4103/ijpvm.ijpvm_293_21 [doi]
PST - epublish
SO  - Int J Prev Med. 2023 May 27;14:68. doi: 10.4103/ijpvm.ijpvm_293_21. eCollection 
      2023.