PMID- 37352397
OWN - NLM
STAT- MEDLINE
DCOM- 20230626
LR  - 20231116
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 54
IP  - 6
DP  - 2023 Jun
TI  - Multimodal Imaging Study of Patients With Vitamin A Deficiency Retinopathy.
PG  - 330-336
LID - 10.3928/23258160-20230513-01 [doi]
AB  - OBJECTIVES: To describe multimodal imaging findings of vitamin A deficiency 
      retinopathy. METHODS: A retrospective study of patients with serum retinol < 0.3 
      mg/L. Fundus color photos, spectral domain-optical coherence tomography (SD-OCT), 
      and fundus autofluorescence (FAF) were reviewed and, when available, 
      electrophysiological tests were analyzed. RESULTS: Forty-five eyes (63.9 +/- 15.7 
      years) were included. Ultra-widefield fundus photography showed drusen-like 
      deposits (53.3%) and macular retinal pigment epithelium (RPE) mottling (40%). The 
      deposits were hypoautofluorescent, and a perifoveal hyperautofluorescent ring was 
      present in 8.9%. By SD-OCT, the ellipsoid zone had an irregular appearance (100%) 
      and conical deposits anterior to the RPE (33.3%). Electroretinogram (ERG) (66.7%) 
      showed a decrease in b-wave in the scotopic registers, and microperimetry (4.4%) 
      showed decreased foveal sensitivity. After vitamin A supplementation, SD-OCT and 
      FAF showed resolution of all findings. Forty percent of eyes had restoration of 
      the scotopic registers in ERG and improved macular sensitivity by microperimetry 
      (4.4%). CONCLUSIONS: Vitamin A deficiency causes a mild cone dysfunction in 
      addition to the more severe absent rod response. [Ophthalmic Surg Lasers Imaging 
      Retina 2023;54:330-336.].
FAU - Pichi, Francesco
AU  - Pichi F
FAU - Aljneibi, Shaikha
AU  - Aljneibi S
FAU - Neri, Piergiorgio
AU  - Neri P
FAU - Rishi, Pukhraj
AU  - Rishi P
FAU - Cicinelli, Maria Vittoria
AU  - Cicinelli MV
FAU - Introini, Ugo
AU  - Introini U
FAU - Sharma, Sumit
AU  - Sharma S
FAU - Munk, Marion R
AU  - Munk MR
FAU - Pasadhika, Sirichai
AU  - Pasadhika S
FAU - Gonzalez-Lopez, Julio J
AU  - Gonzalez-Lopez JJ
FAU - Lembo, Andrea
AU  - Lembo A
FAU - Nucci, Paolo
AU  - Nucci P
FAU - Choudhry, Netan
AU  - Choudhry N
FAU - Carreno, Ester
AU  - Carreno E
LA  - eng
PT  - Journal Article
DEP - 20230601
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
MH  - Humans
MH  - *Vitamin A Deficiency/complications/diagnosis
MH  - Retrospective Studies
MH  - Retina
MH  - *Retinal Diseases
MH  - Vision Disorders
MH  - Tomography, Optical Coherence
MH  - Multimodal Imaging
MH  - Fluorescein Angiography
EDAT- 2023/06/23 19:11
MHDA- 2023/06/26 06:41
CRDT- 2023/06/23 14:23
PHST- 2023/06/26 06:41 [medline]
PHST- 2023/06/23 19:11 [pubmed]
PHST- 2023/06/23 14:23 [entrez]
AID - 10.3928/23258160-20230513-01 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2023 Jun;54(6):330-336. doi: 
      10.3928/23258160-20230513-01. Epub 2023 Jun 1.