PMID- 37353467
OWN - NLM
STAT- MEDLINE
DCOM- 20231204
LR  - 20231217
IS  - 2211-5684 (Electronic)
IS  - 2211-5684 (Linking)
VI  - 104
IP  - 12
DP  - 2023 Dec
TI  - Left atrioventricular coupling index assessed using cardiac CT as a prognostic 
      marker of cardiovascular death.
PG  - 594-604
LID - S2211-5684(23)00146-8 [pii]
LID - 10.1016/j.diii.2023.06.009 [doi]
AB  - PURPOSE: The purpose of this study was to investigate the prognostic value of 
      left atrioventricular coupling index (LACI) assessed by cardiac computed 
      tomography (CT), to predict cardiovascular death in consecutive patients referred 
      for cardiac CT with coronary analysis. MATERIALS AND METHODS: Between 2010 and 
      2020, we conducted a single-centre study with all consecutive patients without 
      known cardiovascular disease referred for cardiac CT. LACI was defined as the 
      ratio of left atrial to left ventricle end-diastolic volumes. The primary outcome 
      was cardiovascular death. Cox regressions were used to evaluate the association 
      between LACI and primary outcome after adjustment for traditional risk factors 
      and cardiac CT angiography findings. RESULTS: In 1,444 patients (mean age, 
      70 +/- 12 [standard deviation] years; 43% men), 67 (4.3%) patients experienced 
      cardiovascular death after a median follow-up of 6.8 (Q1, Q3: 5.9, 9.1) years. 
      After adjustment, LACI was positively associated with the occurrence of 
      cardiovascular death (adjusted hazard ratio [HR], 1.07 [95% CI: 1.05-1.09] per 1% 
      increment; P < 0.001), and all-cause death (adjusted HR, 1.05 [95% CI: 1.03-1.07] 
      per 1% increment; P <0.001). After adjustment, a LACI >/= 25% showed the best 
      improvement in model discrimination and reclassification for predicting 
      cardiovascular death above traditional risk factors and cardiac CT findings 
      (C-statistic improvement: 0.27; Nnet reclassification improvement = 0.826; 
      Integrative discrimination index =0.209, all P < 0.001; likelihood-ratio-test, P 
      < 0.001). CONCLUSION: LACI measured by cardiac CT is independently associated 
      with cardiovascular death and all-cause death in patients without known 
      cardiovascular disease referred for cardiac CT, with an incremental prognostic 
      value over traditional risk factors and cardiac CT findings.
CI  - Copyright (c) 2023. Published by Elsevier Masson SAS.
FAU - Pezel, Theo
AU  - Pezel T
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France; Universite Paris Cite, Department of 
      Radiology, Hopital Lariboisiere - APHP, 75010, Paris, France. Electronic address: 
      theo.pezel@aphp.fr.
FAU - Dillinger, Jean-Guillaume
AU  - Dillinger JG
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
FAU - Toupin, Solenn
AU  - Toupin S
AD  - Siemens Healthcare France, 93200 Saint-Denis, France.
FAU - Mirailles, Raphael
AU  - Mirailles R
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
FAU - Logeart, Damien
AU  - Logeart D
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
FAU - Cohen-Solal, Alain
AU  - Cohen-Solal A
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
FAU - Unger, Alexandre
AU  - Unger A
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France; Department of Cardiology, Hopital 
      Universitaire de Bruxelles - Hopital Erasme, 1070 Brussels, Belgium.
FAU - Canuti, Elena Sofia
AU  - Canuti ES
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France; Department of Clinical, Internal, 
      Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 
      Rome, Italy.
FAU - Beauvais, Florence
AU  - Beauvais F
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
FAU - Lafont, Alexandre
AU  - Lafont A
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
FAU - Goncalves, Trecy
AU  - Goncalves T
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
FAU - Lequipar, Antoine
AU  - Lequipar A
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
FAU - Gall, Emmanuel
AU  - Gall E
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
FAU - Boutigny, Alexandre
AU  - Boutigny A
AD  - Universite Paris Cite, Service des Explorations Fonctionnelles, Hopital 
      Lariboisiere - APHP, Inserm UMRS 942, 75010, Paris, France.
FAU - Ah-Sing, Tania
AU  - Ah-Sing T
AD  - Universite Paris Cite, Department of Radiology, Hopital Lariboisiere - APHP, 
      75010, Paris, France.
FAU - Hamzi, Lounis
AU  - Hamzi L
AD  - Universite Paris Cite, Department of Radiology, Hopital Lariboisiere - APHP, 
      75010, Paris, France.
FAU - Lima, Joao A C
AU  - Lima JAC
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287-0409, USA.
FAU - Bousson, Valerie
AU  - Bousson V
AD  - Universite Paris Cite, Department of Radiology, Hopital Lariboisiere - APHP, 
      75010, Paris, France.
FAU - Henry, Patrick
AU  - Henry P
AD  - Universite Paris Cite, Department of Cardiology, Hopital Lariboisiere - APHP, 
      Inserm UMRS 942, 75010, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20230621
PL  - France
TA  - Diagn Interv Imaging
JT  - Diagnostic and interventional imaging
JID - 101568499
SB  - IM
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Prognosis
MH  - *Coronary Artery Disease
MH  - Tomography, X-Ray Computed/methods
MH  - *Myocardial Infarction
MH  - Computed Tomography Angiography/methods
MH  - Risk Factors
MH  - Predictive Value of Tests
OTO - NOTNLM
OT  - All-cause death
OT  - Cardiac computed tomography angiography
OT  - Cardiovascular death
OT  - Left atrioventricular coupling index
COIS- Declaration of Competing Interest Solenn Toupin is employee of Siemens 
      Healthcare. The other authors declare that they have no competing interests.
EDAT- 2023/06/24 11:42
MHDA- 2023/12/04 12:41
CRDT- 2023/06/23 21:56
PHST- 2023/04/27 00:00 [received]
PHST- 2023/06/12 00:00 [revised]
PHST- 2023/06/15 00:00 [accepted]
PHST- 2023/12/04 12:41 [medline]
PHST- 2023/06/24 11:42 [pubmed]
PHST- 2023/06/23 21:56 [entrez]
AID - S2211-5684(23)00146-8 [pii]
AID - 10.1016/j.diii.2023.06.009 [doi]
PST - ppublish
SO  - Diagn Interv Imaging. 2023 Dec;104(12):594-604. doi: 10.1016/j.diii.2023.06.009. 
      Epub 2023 Jun 21.