PMID- 37353997
OWN - NLM
STAT- MEDLINE
DCOM- 20230630
LR  - 20231119
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 55
IP  - 1
DP  - 2023 Dec
TI  - Association of the endothelial nitric oxide synthase (eNOS) 4a/b polymorphism 
      with the risk of incident diabetic retinopathy in patients with type 2 diabetes 
      mellitus: a systematic review and updated meta-analysis.
PG  - 2226908
LID - 10.1080/07853890.2023.2226908 [doi]
LID - 2226908
AB  - OBJECTIVE: To conduct a systematic review and updated meta-analysis on the 
      potential association between endothelial nitric oxide synthase (eNOS) 4a/b 
      polymorphism and the risk of developing diabetic retinopathy (DR) in patients 
      with type 2 diabetes mellitus (T2DM) and to identify possible clinical biomarkers 
      for early screening of DR. MATERIALS AND METHODS: A meta-analysis based on 
      case-control or cross-sectional studies was conducted to examine the correlation 
      between eNOS 4a/b polymorphism and DR. Pooled odds ratio (OR) and 95% confidence 
      interval (CI) were used to estimate the association strength. RESULTS: We 
      included 19 studies, covering 7838 subjects. An association was observed in 
      Caucasians (allelic model: OR = 1.273, 95% CI: 1.006-1.610, p = .045; recessive 
      model: OR = 0.575, 95% CI: 0.371-0.892, p = .014; dominant model: OR = 1.268, 95% 
      CI: 1.052-1.528, p = .013; homozygote model: OR = 1.833, 95% CI: 1.176-2.856, 
      p = .007). Moreover, population-based studies have indicated an association 
      between eNOS 4a/b polymorphism and DR susceptibility. CONCLUSIONS: The present 
      study showed that intron 4a allele of eNOS 4a/b is a risk factor for DR in 
      Caucasians with T2DM. Thus, eNOS 4a/b may be used as a biomarker for the early 
      screening and diagnosis of DR in Caucasian T2DM patients.Key messagesEndothelial 
      nitric oxide synthase 4a/b gene polymorphism is not associated with the risk of 
      developing diabetic retinopathy in the overall population, Asians, or Chinese Han 
      patients with type 2 diabetes. However, 4a is a risk factor for the development 
      of diabetic retinopathy in Caucasians.Endothelial nitric oxide synthase 4a/b gene 
      polymorphism is not associated with the type of diabetic retinopathy.
FAU - Shi, Yushan
AU  - Shi Y
AUID- ORCID: 0000-0002-1351-2270
AD  - Clinical Medical College, Ningxia Medical University, Yinchuan, Ningxia, China.
FAU - Fan, Xin
AU  - Fan X
AUID- ORCID: 0009-0001-1981-2354
AD  - Department of Ophthalmology, General Hospital of Ningxia Medical University, 
      Yinchuan, Ningxia, China.
FAU - Zhang, Kaiyun
AU  - Zhang K
AUID- ORCID: 0000-0001-7827-0295
AD  - Shaanxi Eye Hospital, Xi'an People's Hospital(Xi'an Fourth Hospital, The People's 
      Hospital Affiliated to Northwest University), Xi'an, Shaanxi, China.
FAU - Ma, Yaling
AU  - Ma Y
AUID- ORCID: 0000-0001-9007-7746
AD  - Department of Ophthalmology, General Hospital of Ningxia Medical University, 
      Yinchuan, Ningxia, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - EC 1.14.13.39 (NOS3 protein, human)
SB  - IM
EIN - Ann Med. 2023 Dec;55(1):2245611. PMID: 37672385
MH  - Humans
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - *Diabetic Retinopathy/etiology/genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - *Nitric Oxide Synthase Type III/genetics
MH  - Polymorphism, Genetic
PMC - PMC10291908
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - endothelial nitric oxide synthase
OT  - intron 4a/b
OT  - meta-analysis
OT  - polymorphism
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2023/06/24 11:42
MHDA- 2023/06/26 06:41
PMCR- 2023/06/24
CRDT- 2023/06/24 04:12
PHST- 2023/06/26 06:41 [medline]
PHST- 2023/06/24 11:42 [pubmed]
PHST- 2023/06/24 04:12 [entrez]
PHST- 2023/06/24 00:00 [pmc-release]
AID - 2226908 [pii]
AID - 10.1080/07853890.2023.2226908 [doi]
PST - ppublish
SO  - Ann Med. 2023 Dec;55(1):2226908. doi: 10.1080/07853890.2023.2226908.