PMID- 37355150
OWN - NLM
STAT- MEDLINE
DCOM- 20230830
LR  - 20230830
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1817
DP  - 2023 Oct 15
TI  - Increased functional connectivity coupling with supplementary motor area in 
      blepharospasm at rest.
PG  - 148469
LID - S0006-8993(23)00240-8 [pii]
LID - 10.1016/j.brainres.2023.148469 [doi]
AB  - OBJECTIVE: To explore the abnormalities of brain function in blepharospasm (BSP) 
      and to illustrate its neural mechanisms by assuming supplementary motor area 
      (SMA) as the entry point. METHODS: Twenty-five patients with BSP and 23 controls 
      underwent resting-state functional MRI, seed-based functional connectivity (FC), 
      correlation analysis, receiver operating characteristic curve (ROC) analysis, and 
      support vector machine (SVM) were applied to process the data. RESULTS: Patients 
      showed that the left medial prefrontal cortex (MPFC), left lingual gyrus, right 
      cerebellar crus I, and right lingual gyrus/cerebellar crus I had enhanced FC with 
      the left SMA, whereas the right inferior temporal gyrus (ITG) had enhanced FC 
      with the right SMA relative to controls. The FC between the left MPFC and left 
      SMA was positively correlated with symptomatic severity. The ROC analysis 
      verified that the abnormal FCs demonstrated in this study can separate patients 
      and controls at high sensitivity and specificity. SVM analysis exhibited that 
      combined FCs of the left SMA were optimal for distinguishing patients and control 
      group at the accuracy of 89.58%, with sensitivity of 92.00% and specificity of 
      86.96%. CONCLUSIONS: Several brain networks partake in the neurobiology of BSP. 
      SMA plays a vital role in several brain networks and might be the key pathogenic 
      factor in BSP. SIGNIFICANCE: Providing novel evidence for the engagement of the 
      MPFC in the motor symptoms of BSP, enhancing credibility of the thesis that SMA 
      regulates the neurobiology of BSP, and providing ideas of screening susceptible 
      population of BSP using neuroimaging.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China; Department of Neurology, Yancheng 
      City No. 1 People's Hospital, Yancheng, Jiangsu 224001, China.
FAU - Yang, Lu
AU  - Yang L
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Yan, Haohao
AU  - Yan H
AD  - Department of Psychiatry, National Clinical Research Center for Mental Disorders, 
      and National Center for Mental Disorders, The Second Xiangya Hospital of Central 
      South University, Changsha 410011, Hunan, China.
FAU - Feng, Changqiang
AU  - Feng C
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Jiang, Wenyan
AU  - Jiang W
AD  - Department of Intensive Care Unit, Tumor Hospital of Guangxi Medical University, 
      Nanning, Guangxi 530021, China.
FAU - Li, Wenmei
AU  - Li W
AD  - Department of Radiology, The First Affiliated Hospital, Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Lei, Yiwu
AU  - Lei Y
AD  - Department of Radiology, The First Affiliated Hospital, Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Pang, Lulu
AU  - Pang L
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Liang, Meilan
AU  - Liang M
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Department of Psychiatry, National Clinical Research Center for Mental Disorders, 
      and National Center for Mental Disorders, The Second Xiangya Hospital of Central 
      South University, Changsha 410011, Hunan, China. Electronic address: 
      guowenbin76@csu.edu.cn.
FAU - Luo, Shuguang
AU  - Luo S
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China. Electronic address: 
      luoshuguang@stu.gxmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230622
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Humans
MH  - *Blepharospasm/diagnostic imaging/physiopathology
MH  - *Motor Cortex/diagnostic imaging/physiopathology
MH  - Rest
MH  - Prefrontal Cortex/diagnostic imaging/physiopathology
MH  - Male
MH  - Adult
MH  - Middle Aged
MH  - *Support Vector Machine
MH  - *Connectome
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - Blepharospasm
OT  - Network
OT  - Resting-state functional MRI
OT  - Seed-based functional connectivity
OT  - Supplementary motor area
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/06/25 01:08
MHDA- 2023/08/29 12:42
CRDT- 2023/06/24 19:16
PHST- 2023/02/26 00:00 [received]
PHST- 2023/06/09 00:00 [revised]
PHST- 2023/06/17 00:00 [accepted]
PHST- 2023/08/29 12:42 [medline]
PHST- 2023/06/25 01:08 [pubmed]
PHST- 2023/06/24 19:16 [entrez]
AID - S0006-8993(23)00240-8 [pii]
AID - 10.1016/j.brainres.2023.148469 [doi]
PST - ppublish
SO  - Brain Res. 2023 Oct 15;1817:148469. doi: 10.1016/j.brainres.2023.148469. Epub 
      2023 Jun 22.