PMID- 37356283
OWN - NLM
STAT- MEDLINE
DCOM- 20230901
LR  - 20230901
IS  - 2772-9508 (Electronic)
IS  - 2772-9508 (Linking)
VI  - 153
DP  - 2023 Oct
TI  - Wound healing performance of electrospun PVA/70S30C bioactive glass/Ag 
      nanoparticles mats decorated with curcumin: In vitro and in vivo investigations.
PG  - 213530
LID - S2772-9508(23)00253-4 [pii]
LID - 10.1016/j.bioadv.2023.213530 [doi]
AB  - Biocompatible fibrous scaffold containing polyvinyl alcohol (PVA), 70S30C 
      bioactive glass (BG), silver (Ag) nanoparticles and curcumin (Cur) was fabricated 
      through electrospinning method. Scanning electron microscope (SEM) and Field 
      emission scanning electron microscopy (FESEM) were employed to investigate the 
      morphological characteristics of the scaffolds. In addition, biodegradability, 
      hydrophilicity, and contact angle were studied as criteria for evaluating 
      physical properties of the scaffolds. Tensile strength was reported to be 
      0.971 +/- 0.093 MPa. Also, the viability of fibroblasts after 7 days of cell 
      culture was 93.58 +/- 1.36 %. The antibacterial activity against Escherichia coli 
      and Staphylococcus aureus bacteria was illustrated using inhibition zones of 
      13.12 +/- 0.69 and 14.21 +/- 1.37 mm, respectively. Histological results revealed 
      that tissue regeneration after 14 days of surgery was much higher for the 
      dressing group compared to the blank group. According to the obtained results, 
      the authors introduce the PVA-BG-Ag-Cur scaffold as a promising candidate for 
      skin tissue engineering applications.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Mahmoudi, Masoud
AU  - Mahmoudi M
AD  - Department of Materials Science and Engineering, Faculty of Engineering & 
      Technology, Tarbiat Modares University, P. O. Box: 14115-143, Tehran, Iran.
FAU - Alizadeh, Parvin
AU  - Alizadeh P
AD  - Department of Materials Science and Engineering, Faculty of Engineering & 
      Technology, Tarbiat Modares University, P. O. Box: 14115-143, Tehran, Iran. 
      Electronic address: p-alizadeh@modares.ac.ir.
FAU - Soltani, Mohammad
AU  - Soltani M
AD  - Department of Materials Science and Engineering, Faculty of Engineering & 
      Technology, Tarbiat Modares University, P. O. Box: 14115-143, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230620
PL  - Netherlands
TA  - Biomater Adv
JT  - Biomaterials advances
JID - 9918383886206676
RN  - 9002-89-5 (Polyvinyl Alcohol)
RN  - 0 (SiO2-CaO glass)
RN  - IT942ZTH98 (Curcumin)
RN  - 3M4G523W1G (Silver)
SB  - IM
MH  - Polyvinyl Alcohol/pharmacology
MH  - *Curcumin/pharmacology
MH  - *Metal Nanoparticles/therapeutic use
MH  - Silver/pharmacology
MH  - Wound Healing
OTO - NOTNLM
OT  - 70S30C bioactive glass
OT  - Curcumin
OT  - Electrospinning
OT  - Polyvinyl alcohol
OT  - Skin
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/06/26 00:41
MHDA- 2023/09/01 06:43
CRDT- 2023/06/25 18:06
PHST- 2023/01/27 00:00 [received]
PHST- 2023/06/09 00:00 [revised]
PHST- 2023/06/17 00:00 [accepted]
PHST- 2023/09/01 06:43 [medline]
PHST- 2023/06/26 00:41 [pubmed]
PHST- 2023/06/25 18:06 [entrez]
AID - S2772-9508(23)00253-4 [pii]
AID - 10.1016/j.bioadv.2023.213530 [doi]
PST - ppublish
SO  - Biomater Adv. 2023 Oct;153:213530. doi: 10.1016/j.bioadv.2023.213530. Epub 2023 
      Jun 20.