PMID- 37357948
OWN - NLM
STAT- MEDLINE
DCOM- 20230817
LR  - 20230829
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 47
IP  - 9
DP  - 2023 Sep 1
TI  - HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and 
      Oropharynx With Multisite Involvement.
PG  - 955-966
LID - 10.1097/PAS.0000000000002086 [doi]
AB  - The prevalence and prognostic significance of high-risk human papillomavirus 
      (HR-HPV) have been well-established in oropharyngeal squamous cell carcinoma 
      (OPSCC), but not in hypopharyngeal squamous cell carcinoma (HPSCC) or laryngeal 
      squamous cell carcinoma (LSCC). Moreover, HR-HPV infection in squamous cell 
      carcinoma with multisite involvement has not been examined. To clarify these 
      issues, we retrospectively collected 480 invasive tumors from 467 patients with 
      HPSCC, LSCC, or OPSCC, and comprehensively analyzed the detailed tumor 
      localization, transcriptionally active HR-HPV infection by messenger RNA in situ 
      hybridization, and immunohistochemical staining for p16 and Rb. HR-HPV infection 
      was observed in 115/480 tumors (24%). Human papillomavirus (HPV)-positive cases 
      were closely related with p16 positivity and the partial loss pattern of Rb. 
      HR-HPV was detected in 104 of 161 tumors (64.6%) in the pure OPSCC group and only 
      1 of 253 tumors (0.4%) in the pure HP/LSCC group; the positive case occurred in 
      the vocal cords. In the multisite-involving combined-type squamous cell carcinoma 
      group, HPV infection was observed in 10/40 (25%) cases, and the 10 HPV-positive 
      cases had OPSCC extending to the larynx or hypopharynx. Among high T-stage 
      (T3/T4) cases of pure OPSCC, HPV-positive cases showed a better prognosis ( P 
      =0.0144), whereas the HPV-positive combined OPSCC group did not show a better 
      prognosis ( P =0.9428), as compared with HPV-negative counterpart. The results 
      suggest that HR-HPV infection in pure HPSCC and LSCC may be extremely rare. 
      HR-HPV infection seems to be present in a substantial proportion of patients with 
      combined OPSCC and HPSCC/LSCC, but it may not improve prognosis at such advanced 
      disease stages. Confirmation of these points awaits future studies with larger 
      cohorts.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Kuga, Ryosuke
AU  - Kuga R
AD  - Departments of Anatomic Pathology.
FAU - Yamamoto, Hidetaka
AU  - Yamamoto H
AD  - Departments of Anatomic Pathology.
FAU - Jiromaru, Rina
AU  - Jiromaru R
AD  - Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka.
FAU - Hongo, Takahiro
AU  - Hongo T
AD  - Departments of Anatomic Pathology.
AD  - Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka.
FAU - Yasumatsu, Ryuji
AU  - Yasumatsu R
AD  - Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka.
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, 
      Kindai University, Osaka, Japan.
FAU - Matsuo, Mioko
AU  - Matsuo M
AD  - Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka.
FAU - Hashimoto, Kazuki
AU  - Hashimoto K
AD  - Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka.
FAU - Taniguchi, Midori
AU  - Taniguchi M
AD  - Departments of Anatomic Pathology.
FAU - Nakagawa, Takashi
AU  - Nakagawa T
AD  - Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka.
FAU - Oda, Yoshinao
AU  - Oda Y
AD  - Departments of Anatomic Pathology.
LA  - eng
PT  - Journal Article
DEP - 20230626
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
SB  - IM
MH  - Humans
MH  - *Papillomavirus Infections/complications/epidemiology
MH  - Hypopharynx/pathology
MH  - Retrospective Studies
MH  - *Carcinoma, Squamous Cell/pathology
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Prognosis
MH  - *Head and Neck Neoplasms
MH  - Oropharynx/pathology
MH  - *Larynx/pathology
MH  - *Oropharyngeal Neoplasms
MH  - Cyclin-Dependent Kinase Inhibitor p16/genetics
MH  - Papillomaviridae/genetics
COIS- Conflicts of Interest and Source of Funding: The authors have disclosed that they 
      have no significant relationships with, or financial interest in, any commercial 
      companies pertaining to this article.
EDAT- 2023/06/26 13:07
MHDA- 2023/08/17 06:42
CRDT- 2023/06/26 06:48
PHST- 2023/08/17 06:42 [medline]
PHST- 2023/06/26 13:07 [pubmed]
PHST- 2023/06/26 06:48 [entrez]
AID - 00000478-202309000-00001 [pii]
AID - 10.1097/PAS.0000000000002086 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2023 Sep 1;47(9):955-966. doi: 10.1097/PAS.0000000000002086. 
      Epub 2023 Jun 26.