PMID- 37359987
OWN - NLM
STAT- Publisher
LR  - 20230928
IS  - 0032-3896 (Print)
IS  - 1349-0540 (Electronic)
IS  - 0032-3896 (Linking)
DP  - 2023 May 17
TI  - Polymeric core-crosslinked particles prepared via a nanoemulsion-mediated 
      process: from particle design and structural characterization to in vivo behavior 
      in chemotherapy.
PG  - 1-13
LID - 10.1038/s41428-023-00793-6 [doi]
AB  - Various polymeric nanoparticles have been used as drug carriers in drug delivery 
      systems (DDSs). Most of them were constructed from dynamic self-assembly systems 
      formed via hydrophobic interactions and from structures that are unstable in an 
      in vivo environment owing to their relatively weak formation forces. As a 
      solution to this issue, physically stabilized core-crosslinked particles (CP) 
      with chemically crosslinked cores have received attention as alternatives to the 
      dynamic nanoparticles. This focused review summarizes recent advances in the 
      construction, structural characterization, and in vivo behavior of polymeric CPs. 
      First, we introduce a nanoemulsion-mediated method to create polyethylene glycol 
      (PEG)-bearing CPs and their structural characterization. The relationship between 
      the PEG chain conformations in the particle shell and the in vivo fate of the CPs 
      is also discussed. After that, the development and advantages of zwitterionic 
      amino acid-based polymer (ZAP)-bearing CPs are presented to address the poor 
      penetration and the internalization of PEG-based CPs into tumor tissues and 
      cells, respectively. Finally, we conclude and discuss prospects for application 
      of polymeric CPs in the DDS field.
CI  - (c) The Author(s), under exclusive licence to The Society of Polymer Science, Japan 
      2023, Springer Nature or its licensor (e.g. a society or other partner) holds 
      exclusive rights to this article under a publishing agreement with the author(s) 
      or other rightsholder(s); author self-archiving of the accepted manuscript 
      version of this article is solely governed by the terms of such publishing 
      agreement and applicable law.
FAU - Fujii, Shota
AU  - Fujii S
AD  - Polymer Science and Engineering Department, University of Massachusetts, Amherst, 
      MA 01003 USA. GRID: grid.266683.f. ISNI: 0000 0001 2166 5835
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230517
PL  - Japan
TA  - Polym J
JT  - Polymer journal
JID - 101535832
PMC - PMC10189226
OTO - NOTNLM
OT  - Drug delivery
OT  - Polymer synthesis
COIS- Conflict of interestThe authors declare no competing interests.
EDAT- 2023/06/26 19:07
MHDA- 2023/06/26 19:07
PMCR- 2023/05/17
CRDT- 2023/06/26 12:30
PHST- 2023/01/30 00:00 [received]
PHST- 2023/04/12 00:00 [revised]
PHST- 2023/04/13 00:00 [accepted]
PHST- 2023/06/26 19:07 [pubmed]
PHST- 2023/06/26 19:07 [medline]
PHST- 2023/06/26 12:30 [entrez]
PHST- 2023/05/17 00:00 [pmc-release]
AID - 793 [pii]
AID - 10.1038/s41428-023-00793-6 [doi]
PST - aheadofprint
SO  - Polym J. 2023 May 17:1-13. doi: 10.1038/s41428-023-00793-6.