PMID- 37362552
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230701
IS  - 2632-7899 (Electronic)
IS  - 2632-7899 (Linking)
VI  - 4
IP  - 1
DP  - 2023 Jan
TI  - Negative Symptom Trajectories in Individuals at Clinical High Risk for Psychosis: 
      Differences Based on Deficit Syndrome, Persistence, and Transition Status.
PG  - sgad014
LID - 10.1093/schizbullopen/sgad014 [doi]
LID - sgad014
AB  - BACKGROUND AND HYPOTHESIS: Negative symptom trajectory in clinical high risk 
      (CHR) for psychosis is ill defined. This study aimed to better characterize 
      longitudinal patterns of change in negative symptoms, moderators of change, and 
      differences in trajectories according to clinical subgroups. We hypothesized that 
      negative symptom course will be nonlinear in CHR. Clinical subgroups known to be 
      more severe variants of psychotic illness-deficit syndrome (DS), persistent 
      negative syndrome (PNS), and acute psychosis onset-were expected to show more 
      severe baseline symptoms, slower rates of change, and less stable rates of 
      symptom resolution. STUDY DESIGN: Linear, curvilinear, and stepwise growth curve 
      models, with and without moderators, were fitted to negative symptom ratings from 
      the NAPLS-3 CHR dataset (N = 699) and within clinical subgroups. STUDY RESULTS: 
      Negative symptoms followed a downward curvilinear trend, with marked improvement 
      0-6 months that subsequently stabilized (6-24 months), particularly among those 
      with lower IQ and functioning. Clinical subgroups had higher baseline ratings, 
      but distinct symptom courses; DS vs non-DS: more rapid initial improvement, 
      similar stability of improvements; PNS vs non-PNS: similar rates of initial 
      improvement and stability; transition vs no transition: slower rate of initial 
      improvement, with greater stability of this rate. CONCLUSIONS: Continuous, 
      frequent monitoring of negative symptoms in CHR is justified by 2 important study 
      implications: (1) The initial 6 months of CHR program enrollment may be a key 
      window for improving negative symptoms as less improvement is likely afterwards, 
      (2) Early identification of clinical subgroups may inform distinct negative 
      symptom trajectories and treatment needs.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      University of Maryland's school of medicine, Maryland Psychiatric Research 
      Center.
FAU - Tran, Tanya
AU  - Tran T
AUID- ORCID: 0000-0002-6303-8394
AD  - Department of Psychology, Queen's University, Kingston, ON, Canada.
FAU - Spilka, Michael J
AU  - Spilka MJ
AD  - Department of Psychology, University of Georgia, Athens, GA, USA.
FAU - Raugh, Ian M
AU  - Raugh IM
AUID- ORCID: 0000-0003-4981-2395
AD  - Department of Psychology, University of Georgia, Athens, GA, USA.
FAU - Strauss, Gregory P
AU  - Strauss GP
AD  - Department of Psychology, University of Georgia, Athens, GA, USA.
FAU - Bearden, Carrie E
AU  - Bearden CE
AUID- ORCID: 0000-0002-8516-923X
AD  - Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AUID- ORCID: 0000-0002-5952-4605
AD  - Department of Psychiatry, UCSD, San Diego, CA, USA.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, CT, USA.
AD  - Department of Psychiatry, Yale University, New Haven, CT, USA.
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
AD  - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, USA.
FAU - Keshavan, Matcheri
AU  - Keshavan M
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts Mental Health Center, Boston, MA, USA.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - Department of Psychiatry, UCSF, and SFVA Medical Center, San Francisco, CA, USA.
FAU - McGlashan, Thomas H
AU  - McGlashan TH
AD  - Department of Psychiatry, Yale University, New Haven, CT, USA.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts Mental Health Center, Boston, MA, USA.
FAU - Stone, William S
AU  - Stone WS
AUID- ORCID: 0000-0003-2932-7288
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts Mental Health Center, Boston, MA, USA.
FAU - Tsuang, Ming T
AU  - Tsuang MT
AD  - Department of Psychiatry, UCSD, San Diego, CA, USA.
AD  - Institute of Genomic Medicine, University of California, La Jolla, CA, USA.
FAU - Walker, Elaine F
AU  - Walker EF
AUID- ORCID: 0000-0002-9798-8101
AD  - Department of Psychology, Emory University, Atlanta, GA, USA.
AD  - Department of Psychiatry, Emory University, Atlanta, GA, USA.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, CT, USA.
FAU - Addington, Jean M
AU  - Addington JM
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Calgary, AB, Canada.
LA  - eng
PT  - Journal Article
DEP - 20230601
PL  - United States
TA  - Schizophr Bull Open
JT  - Schizophrenia bulletin open
JID - 101770329
PMC - PMC10287168
OTO - NOTNLM
OT  - cognition
OT  - functioning
OT  - growth curve analysis
OT  - symptom course
EDAT- 2023/06/26 19:07
MHDA- 2023/06/26 19:08
PMCR- 2023/06/01
CRDT- 2023/06/26 13:07
PHST- 2023/06/26 19:08 [medline]
PHST- 2023/06/26 19:07 [pubmed]
PHST- 2023/06/26 13:07 [entrez]
PHST- 2023/06/01 00:00 [pmc-release]
AID - sgad014 [pii]
AID - 10.1093/schizbullopen/sgad014 [doi]
PST - epublish
SO  - Schizophr Bull Open. 2023 Jun 1;4(1):sgad014. doi: 10.1093/schizbullopen/sgad014. 
      eCollection 2023 Jan.