PMID- 37364698
OWN - NLM
STAT- MEDLINE
DCOM- 20230714
LR  - 20230718
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 878
DP  - 2023 Aug 20
TI  - Association between GLP-1R gene polymorphism and dyslipidemia in Chinese patients 
      with type 2 diabetes mellitus: A case-control study.
PG  - 147589
LID - S0378-1119(23)00430-4 [pii]
LID - 10.1016/j.gene.2023.147589 [doi]
AB  - OBJECTIVE: To evaluate the relationship between GLP-1R gene polymorphisms and 
      type 2 diabetes mellitus with dyslipidemia and without dyslipidemia in China. 
      METHODS: A total of 200 patients with Type 2 Diabetes Mellitus (T2DM) were 
      included in this study, including 115 with dyslipidemia and 85 without 
      dyslipidemia. We used Sanger double deoxygenation terminal assay and PCR-RFLP to 
      detect genotype of the GLP-1R rs10305420 and rs3765467 loci. T-test was used to 
      analyze the association between gene polymorphisms and lipid indicators. SHEsis 
      online analysis software was used to analyze the linkage balance effect of loci, 
      and SPSS 26 was used to calculate the gene interaction by dominant model. 
      RESULTS: The genotype distribution of the two loci in the sample of this study 
      was in accordance with Hardy-weinberg equilibrium. There were significant 
      differences in the genotype distribution and allele frequency of rs3765467 
      between T2DM patients with and without dyslipidemia (GG 52.9%, GA + AA 47.1% vs. 
      GG 69.6%, GA + AA 30.4%; P = 0.017). Under the dominant model, the effects of 
      rs3765467 A allele and rs10305420 T allele on dyslipidemia had multiplicative 
      interactions (P = 0.016) and additive interactions (RERI = 0.403, 95% CI [-2.708 
      to 3.514]; AP = 0.376, 95% CI [-2.041, 2.793]). Meanwhile, HbA(1c) levels in 
      rs3765467 A allele carriers (GA + AA) were found to be significantly lower than 
      those in patients with GG genotype (P = 0.006). CONCLUSION: The rs3765467 (G/A) 
      variant is associated with the incidence of dyslipidemia, and G allele may be a 
      risk factor for dyslipidemia.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Li, Yue
AU  - Li Y
AD  - Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical 
      University & Shandong 6 Provincial Qianfoshan Hospital, Jinan, Shandong, China. 
      Electronic address: jiduoxintiao110@163.com.
FAU - Yang, Zhiyan
AU  - Yang Z
AD  - Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical 
      University & Shandong 6 Provincial Qianfoshan Hospital, Jinan, Shandong, China. 
      Electronic address: yangzhiyan00@163.com.
FAU - Ren, Shuyu
AU  - Ren S
AD  - Jinan Xinhang Experimental Foreign Language School, Jinan, Shandong, China. 
      Electronic address: 2456493636@qq.com.
FAU - Shen, Bowen
AU  - Shen B
AD  - Department of Pharmacy, Shandong First Medical University, Taian, Shandong, 
      China. Electronic address: 1565902480@qq.com.
FAU - Zhang, Yundi
AU  - Zhang Y
AD  - Department of Pharmacy, Shandong University of Traditional Chinese Medicine, 
      Jinan, Shandong, China. Electronic address: 2216072194@qq.com.
FAU - Zong, Huiying
AU  - Zong H
AD  - Department of Pharmacy, Shandong University of Traditional Chinese Medicine, 
      Jinan, Shandong, China. Electronic address: zongzong33@163.com.
FAU - Li, Yan
AU  - Li Y
AD  - Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical 
      University & Shandong 6 Provincial Qianfoshan Hospital, Jinan, Shandong, China. 
      Electronic address: li_xyan@126.com.
LA  - eng
PT  - Journal Article
DEP - 20230624
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (GLP1R protein, human)
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
SB  - IM
MH  - Humans
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/genetics/epidemiology
MH  - *Dyslipidemias/genetics
MH  - East Asian People
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Polymorphism, Single Nucleotide
MH  - *Glucagon-Like Peptide-1 Receptor/genetics
OTO - NOTNLM
OT  - Dyslipidemia
OT  - GLP-1R gene
OT  - Lipid profile
OT  - Mutation
OT  - T2DM
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/06/27 01:06
MHDA- 2023/07/14 13:07
CRDT- 2023/06/26 19:20
PHST- 2023/04/26 00:00 [received]
PHST- 2023/06/11 00:00 [revised]
PHST- 2023/06/21 00:00 [accepted]
PHST- 2023/07/14 13:07 [medline]
PHST- 2023/06/27 01:06 [pubmed]
PHST- 2023/06/26 19:20 [entrez]
AID - S0378-1119(23)00430-4 [pii]
AID - 10.1016/j.gene.2023.147589 [doi]
PST - ppublish
SO  - Gene. 2023 Aug 20;878:147589. doi: 10.1016/j.gene.2023.147589. Epub 2023 Jun 24.