PMID- 37365351
OWN - NLM
STAT- MEDLINE
DCOM- 20231010
LR  - 20231229
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 280
IP  - 11
DP  - 2023 Nov
TI  - Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with 
      seasonal allergic rhinoconjunctivitis over two pollen seasons.
PG  - 4939-4947
LID - 10.1007/s00405-023-08078-7 [doi]
AB  - OBJECTIVE: This study investigates the efficacy and safety of sublingual 
      immunotherapy (SLIT) with A. annua allergens in patients with seasonal allergic 
      rhinoconjunctivitis over two pollen seasons. METHODS: Seventy patients with 
      moderate-severe seasonal allergic rhinoconjunctivitis were divided evenly into 
      the SLIT and control groups. The SLIT last from 3 months before the summer-autumn 
      pollen season in 2021 till the end of the summer-autumn pollen season in 2022. 
      The daily individual symptom score, total rhinoconjunctivitis symptom score 
      (dTRSS), total medication score (dTMS), combined score of medication and 
      rhinoconjunctivitis symptom (dCSMRS), visual analog scale (VAS) score, and 
      adverse events (AEs) were evaluated. RESULTS: The average pollen concentration in 
      2022 was twice that previous two-year during the pollen season. Fifty-six 
      patients completed treatments (SLIT group: 29, control group: 27). Compared with 
      baseline, the individual symptoms, dTRSS, dTMS, dCSMRS, and VAS scores of SLIT 
      group declined in 2021. After 16 months of SLIT, all efficacy indexes in 2022 
      were still lower than baseline and equivalent to those in 2021. In control group, 
      the efficacy indexes in 2022 were higher than that in 2020 and 2021. The efficacy 
      indexes of SLIT group were lower than those of control group in 2021 and 2022. 
      SLIT is effective for both mono- and poly-sensitized patients. AEs incidence in 
      SLIT group was 82.7% without severe AEs. CONCLUSIONS: The A. annua-SLIT can 
      obtain efficacy and safety over two pollen seasons for patients with 
      moderate-severe seasonal allergic rhinoconjunctivitis.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Yang, Jiayi
AU  - Yang J
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China.
FAU - Wang, Weidong
AU  - Wang W
AD  - Department of Otolaryngology Head and Neck Surgery, NO. 215 Hospital of Shaanxi 
      Nuclear Industry, Xianyang, 710054, China.
FAU - Shen, Zhen
AU  - Shen Z
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China.
FAU - Kang, Wei
AU  - Kang W
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China.
FAU - Zhang, Pengfei
AU  - Zhang P
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China.
FAU - Chen, Xin
AU  - Chen X
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China.
FAU - Li, Huajing
AU  - Li H
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China.
FAU - Shao, Yuan
AU  - Shao Y
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China.
FAU - Liu, Lifeng
AU  - Liu L
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China.
FAU - Zhang, Shaoqiang
AU  - Zhang S
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China. entsqzhang@163.com.
FAU - Quan, Fang
AU  - Quan F
AUID- ORCID: 0000-0002-9984-9121
AD  - Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of 
      Xi'an Jiaotong University, Xian, 710061, China. quanfang2013@163.com.
LA  - eng
GR  - 2020SF-020/Key Research and Development Projects of Shaanxi Province/
GR  - XJTU1AF-CRF-2022-022/First Affiliated Hospital of Zhengzhou University/
PT  - Journal Article
DEP - 20230626
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Allergens)
SB  - IM
MH  - Humans
MH  - Seasons
MH  - *Sublingual Immunotherapy/adverse effects
MH  - *Rhinitis, Allergic, Seasonal/therapy
MH  - *Artemisia annua
MH  - *Conjunctivitis, Allergic/therapy
MH  - Double-Blind Method
MH  - Pollen
MH  - Allergens
MH  - Desensitization, Immunologic/adverse effects
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Allergic conjunctivitis
OT  - Allergic rhinitis
OT  - Inhaled allergen
OT  - Pollen concentration
EDAT- 2023/06/27 01:06
MHDA- 2023/10/10 06:42
CRDT- 2023/06/26 23:28
PHST- 2023/04/21 00:00 [received]
PHST- 2023/06/14 00:00 [accepted]
PHST- 2023/10/10 06:42 [medline]
PHST- 2023/06/27 01:06 [pubmed]
PHST- 2023/06/26 23:28 [entrez]
AID - 10.1007/s00405-023-08078-7 [pii]
AID - 10.1007/s00405-023-08078-7 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2023 Nov;280(11):4939-4947. doi: 
      10.1007/s00405-023-08078-7. Epub 2023 Jun 26.