PMID- 37365577
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230701
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 15
IP  - 1
DP  - 2023 Jun 26
TI  - Comparison of fasting and random lipid profiles among subjects with type 2 
      diabetes mellitus: an outpatient-based cross-sectional study in Bangladesh.
PG  - 139
LID - 10.1186/s13098-023-01120-y [doi]
LID - 139
AB  - BACKGROUND: Despite the wide acceptability of fasting lipid profiles in practice, 
      emerging evidence suggests that random lipid profiles might be a convenient 
      alternative for lipid measurement. The objective of the present study was to 
      compare the fasting and random lipid profile among subjects with type 2 diabetes 
      mellitus (T2DM). METHODS: The present cross-sectional study included 1543 
      subjects with T2DM visiting several endocrinology outpatient clinics throughout 
      Bangladesh from January to December 2021. The fasting lipid profile was measured 
      in the morning following 8-10 h of overnight fasting, and the random lipid 
      profile was measured at any time of the day, irrespective of the last meal. The 
      values of fasting and random lipids were compared using the Wilcoxon signed-rank 
      test and Spearman rank correlation coefficients. RESULTS: In this study, a good 
      level of correlation was observed between fasting and random lipid levels 
      [r = 0.793, p < 0.001 for triglyceride (TG); r = 0.873, p < 0.001 for low-density 
      lipoprotein cholesterol (LDL-C); r = 0.609, p < 0.001 for high-density 
      lipoprotein cholesterol (HDL-C); and r = 0.780, p < 0.001 for total cholesterol 
      (TC)]. In addition, TG and TC levels increased by 14% and 0.51%, respectively, in 
      the random state compared to the fasting state (p- <0.05), while LDL-C levels 
      decreased by 0.71% (p-value 0.42). No change was noticed in the HDL-C level. The 
      difference between fasting and random lipid profiles was similar irrespective of 
      patients' age, sex, BMI, glucose-lowering drug(s), and lipid-lowering therapy. 
      CONCLUSIONS: Random lipid profile correlates significantly with fasting lipid 
      profile with little difference. Hence, it might be a reliable alternative for 
      fasting lipid profile in patients with T2DM.
CI  - (c) 2023. The Author(s).
FAU - Kamrul-Hasan, A B M
AU  - Kamrul-Hasan ABM
AUID- ORCID: 0000-0002-5681-6522
AD  - Department of Endocrinology, Mymensingh Medical College, Mymensingh, Bangladesh. 
      rangassmc@gmail.com.
FAU - Talukder, Samir Kumar
AU  - Talukder SK
AUID- ORCID: 0000-0001-5240-8225
AD  - Department of Endocrinology, Rangpur Medical College, Rangpur, Bangladesh.
FAU - Kabir, Md Ahamedul
AU  - Kabir MA
AUID- ORCID: 0000-0003-4410-4808
AD  - Department of Endocrinology, Rangpur Medical College, Rangpur, Bangladesh.
AD  - Department of Endocrinology, TMSS Medical College, Bogura, Bangladesh.
FAU - Mustari, Marufa
AU  - Mustari M
AUID- ORCID: 0000-0002-8519-4988
AD  - Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, 
      Bangladesh.
FAU - Un Nabi, Md Masud
AU  - Un Nabi MM
AUID- ORCID: 0000-0002-8749-2575
AD  - Department of Endocrinology, Rajshahi Medical College, Rajshahi, Bangladesh.
FAU - Gaffar, Abu Jar
AU  - Gaffar AJ
AUID- ORCID: 0000-0002-7334-9751
AD  - Department of Pathology, Naogaon Medical College, Naogaon, Bangladesh.
FAU - Hossain, Md Firoj
AU  - Hossain MF
AUID- ORCID: 0000-0002-2351-8879
AD  - Department of Endocrinology, Mugda Medical College, Dhaka, Bangladesh.
FAU - Alam, Muhammad Shah
AU  - Alam MS
AUID- ORCID: 0000-0002-9541-5641
AD  - Department of Medicine, Army Medical College Cumilla, Cumilla, Bangladesh.
FAU - Islam, Md Rashedul
AU  - Islam MR
AUID- ORCID: 0000-0003-2101-9694
AD  - Department of Neurology, BIRDEM General Hospital, Dhaka, Bangladesh.
FAU - Hannan, Mohammad Abdul
AU  - Hannan MA
AUID- ORCID: 0000-0002-3285-6343
AD  - Department of Endocrinology, North East Medical College, Sylhet, Bangladesh.
FAU - Zarin, Nusrat
AU  - Zarin N
AUID- ORCID: 0000-0003-0657-5318
AD  - Department of Endocrinology, Bangladesh Institute of Health Sciences, Dhaka, 
      Bangladesh.
FAU - Paul, Ajit Kumar
AU  - Paul AK
AUID- ORCID: 0000-0002-2734-3893
AD  - Department of Endocrinology, Mainamoti Medical College, Cumilla, Bangladesh.
FAU - Akter, Farhana
AU  - Akter F
AUID- ORCID: 0000-0002-4488-9388
AD  - Department of Endocrinology, Chittagong Medical College, Chittagong, Bangladesh.
FAU - Ahammed, Afsar
AU  - Ahammed A
AUID- ORCID: 0000-0002-1910-0613
AD  - Department of Endocrinology, National Institute of Traumatology and Orthopaedic 
      Rehabilitation (NITOR), Dhaka, Bangladesh.
FAU - Kabir, Md Lutful
AU  - Kabir ML
AUID- ORCID: 0000-0003-1376-3376
AD  - Department of Endocrinology, Rangpur Medical College, Rangpur, Bangladesh.
FAU - Rahman, Mohammad Motiur
AU  - Rahman MM
AUID- ORCID: 0000-0002-6101-3812
AD  - Department of Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh.
FAU - Asaduzzaman, Md
AU  - Asaduzzaman M
AUID- ORCID: 0000-0002-8354-987X
AD  - Department of Endocrinology, Shaheed Sheikh Abu Naser Specialized Hospital, 
      Khulna, Bangladesh.
FAU - Saifuddin, Mohammad
AU  - Saifuddin M
AUID- ORCID: 0000-0001-6121-1192
AD  - Department of Endocrinology, Dhaka Medical College, Dhaka, Bangladesh.
FAU - Chanda, Palash Kumar
AU  - Chanda PK
AUID- ORCID: 0000-0003-3083-7779
AD  - Department of Endocrinology, Mymensingh Medical College Hospital, Mymensingh, 
      Bangladesh.
FAU - Rafi, Md Abdur
AU  - Rafi MA
AD  - Pi Research Development Center, Dhaka, Bangladesh.
FAU - Hasan, Mohammad Jahid
AU  - Hasan MJ
AD  - Pi Research Development Center, Dhaka, Bangladesh. dr.jahid61@gmail.com.
FAU - Selim, Shahjada
AU  - Selim S
AUID- ORCID: 0000-0001-7749-3542
AD  - Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, 
      Bangladesh.
LA  - eng
PT  - Journal Article
DEP - 20230626
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC10291787
OTO - NOTNLM
OT  - Cardiovascular risk
OT  - Fasting lipid profile
OT  - Lipid-lowering therapy
OT  - Random lipid profile
OT  - T2DM
COIS- The authors declare that they have no competing interests.
EDAT- 2023/06/27 01:06
MHDA- 2023/06/27 01:07
PMCR- 2023/06/26
CRDT- 2023/06/26 23:39
PHST- 2022/07/15 00:00 [received]
PHST- 2023/06/21 00:00 [accepted]
PHST- 2023/06/27 01:07 [medline]
PHST- 2023/06/27 01:06 [pubmed]
PHST- 2023/06/26 23:39 [entrez]
PHST- 2023/06/26 00:00 [pmc-release]
AID - 10.1186/s13098-023-01120-y [pii]
AID - 1120 [pii]
AID - 10.1186/s13098-023-01120-y [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2023 Jun 26;15(1):139. doi: 10.1186/s13098-023-01120-y.