PMID- 37365869
OWN - NLM
STAT- Publisher
LR  - 20230627
IS  - 1545-1550 (Electronic)
IS  - 1526-6028 (Linking)
DP  - 2023 Jun 26
TI  - Long-Term Outcomes of Drug-Eluting Stent Implantation for Patients With 
      Atherosclerotic Erectile Dysfunction not Responding to PDE-5-Inhibitors.
PG  - 15266028231183775
LID - 10.1177/15266028231183775 [doi]
AB  - PURPOSE: Endovascular therapy of erection-related arteries was shown to be a 
      promising treatment option for patients with severe erectile dysfunction. Purpose 
      of this study was to assess the longer-term safety and clinical success rate of 
      endovascular revascularization of erection-related arteries with the Angiolite 
      BTK stent in patients with arteriogenic erectile dysfunction. MATERIALS AND 
      METHODS: A total of 147 consecutive men (63.5+/-9.3 years) with erectile 
      dysfunction due to 345 atherosclerotic lesions underwent endovascular 
      revascularization. Patients received an International Index of Erectile Function 
      (IIEF)-15 questionnaire at 30.3+/-7.2 months (follow-up [FU] period no less than 18 
      months) after stenting. An improvement by 4 points in the erectile function 
      domain consisting of 6 questions (IIEF-6) was defined as minimal clinically 
      important difference (MCID). RESULTS: Technical success was achieved in 99% of 
      lesions. One major adverse event occurred after endovascular revascularization. 
      Sixty-eight (46%) patients completed their latest FU at least 18 months following 
      the last intervention. Minimal clinically important difference was achieved in 
      54% (37/68) of patients. CONCLUSIONS: In patients with arteriogenic erectile 
      dysfunction not responding to phosphodiesterase-5-inhibitors (PDE-5-Is), 
      endovascular therapy with a novel thin-strut sirolimus-eluting stent is a safe 
      and effective treatment option during short- and longer-term FU. CLINICAL IMPACT: 
      Patients with severe erectile dysfunction profit greatly from endovascular 
      therapy of erection-related arteries. Stable clinical outcomes are seen beyond a 
      1-year timeframe. It is proven that, the drug-eluting stent therapy for 
      atherosclerotic ED in patients who have not responded to PDE-5-I therapy is safe 
      and effective during longer-term follow-up.
FAU - Mohan, Vignes
AU  - Mohan V
AUID- ORCID: 0000-0001-6574-3284
AD  - Vascular Institute Central Switzerland, Aarau, Switzerland.
FAU - Schonhofen, Jan
AU  - Schonhofen J
AD  - Department of Internal Medicine, Spitalzentrum Biel AG, Biel, Switzerland.
FAU - Hoppe, Hanno
AU  - Hoppe H
AD  - SwissIntervention Microtherapy Center, Bern, Switzerland.
AD  - University of Bern, Bern, Switzerland.
FAU - Schumacher, Martin
AU  - Schumacher M
AD  - Department of Urology, Hirslanden Clinic Aarau, Aarau, Switzerland.
FAU - Keo, Hak-Hong
AU  - Keo HH
AD  - Vascular Institute Central Switzerland, Aarau, Switzerland.
FAU - Bechir, Markus
AU  - Bechir M
AD  - Center for Internal Medicine, Hirslanden Clinic Aarau, Aarau, Switzerland.
FAU - Kalka, Christoph
AU  - Kalka C
AD  - Vascular Institute Central Switzerland, Aarau, Switzerland.
AD  - University of Bern, Bern, Switzerland.
FAU - Burkhard Rn, Madlen
AU  - Burkhard Rn M
AD  - Vascular Institute Central Switzerland, Aarau, Switzerland.
FAU - Diehm, Nicolas
AU  - Diehm N
AUID- ORCID: 0000-0001-5674-0073
AD  - Vascular Institute Central Switzerland, Aarau, Switzerland.
AD  - University of Bern, Bern, Switzerland.
AD  - University of Applied Sciences Furtwangen, Villingen-Schwenningen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230626
PL  - United States
TA  - J Endovasc Ther
JT  - Journal of endovascular therapy : an official journal of the International 
      Society of Endovascular Specialists
JID - 100896915
SB  - IM
OTO - NOTNLM
OT  - PDE-5-inhibitors
OT  - drug-eluting stent
OT  - erection
OT  - pudendal
EDAT- 2023/06/27 06:42
MHDA- 2023/06/27 06:42
CRDT- 2023/06/27 02:33
PHST- 2023/06/27 06:42 [medline]
PHST- 2023/06/27 06:42 [pubmed]
PHST- 2023/06/27 02:33 [entrez]
AID - 10.1177/15266028231183775 [doi]
PST - aheadofprint
SO  - J Endovasc Ther. 2023 Jun 26:15266028231183775. doi: 10.1177/15266028231183775.