PMID- 37366063
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231027
IS  - 1674-8301 (Print)
IS  - 2352-4685 (Electronic)
IS  - 1674-8301 (Linking)
VI  - 37
IP  - 5
DP  - 2023 Apr 28
TI  - Circular RNA expression and the competitive endogenous RNA network in 
      pathological, age-related macular degeneration events: A cross-platform 
      normalization study.
PG  - 367-381
LID - 10.7555/JBR.37.20230010 [doi]
AB  - Age-related macular degeneration (AMD) causes irreversible blindness in people 
      aged over 50 worldwide. The dysfunction of the retinal pigment epithelium is the 
      primary cause of atrophic AMD. In the current study, we used the ComBat and 
      Training Distribution Matching method to integrate data obtained from the Gene 
      Expression Omnibus database. We analyzed the integrated sequencing data by the 
      Gene Set Enrichment Analysis. Peroxisome and tumor necrosis factor-alpha (TNF-alpha) 
      signaling and nuclear factor kappa B (NF-kappaB) were among the top 10 pathways, and 
      thus we selected them to construct AMD cell models to identify differentially 
      expressed circular RNAs (circRNAs). We then constructed a competing endogenous 
      RNA network, which is related to differentially expressed circRNAs. This network 
      included seven circRNAs, 15 microRNAs, and 82 mRNAs. The Kyoto Encyclopedia of 
      Genes and Genomes analysis of mRNAs in this network showed that the 
      hypoxia-inducible factor-1 (HIF-1) signaling pathway was a common downstream 
      event. The results of the current study may provide insights into the 
      pathological processes of atrophic AMD.
FAU - Sun, Ruxu
AU  - Sun R
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
FAU - Zhu, Hongjing
AU  - Zhu H
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
FAU - Wang, Jianan
AU  - Wang J
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
FAU - Jiang, Chao
AU  - Jiang C
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
FAU - Cao, Qiuchen
AU  - Cao Q
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
FAU - Zhang, Yeran
AU  - Zhang Y
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
FAU - Zhang, Yichen
AU  - Zhang Y
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
FAU - Yuan, Songtao
AU  - Yuan S
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
FAU - Liu, Qinghuai
AU  - Liu Q
AD  - Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical 
      University, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Biomed Res
JT  - Journal of biomedical research
JID - 101551157
PMC - PMC10541779
OTO - NOTNLM
OT  - age-related macular degeneration
OT  - bioinformatics analysis
OT  - circular RNA
OT  - competing endogenous RNA
OT  - retinal pigment epithelium
COIS- The authors reported no conflict of interests.
EDAT- 2023/06/27 06:42
MHDA- 2023/06/27 06:43
PMCR- 2023/09/01
CRDT- 2023/06/27 05:26
PHST- 2023/06/27 06:43 [medline]
PHST- 2023/06/27 06:42 [pubmed]
PHST- 2023/06/27 05:26 [entrez]
PHST- 2023/09/01 00:00 [pmc-release]
AID - jbr-37-5-367 [pii]
AID - 10.7555/JBR.37.20230010 [doi]
PST - ppublish
SO  - J Biomed Res. 2023 Apr 28;37(5):367-381. doi: 10.7555/JBR.37.20230010.