PMID- 37366092
OWN - NLM
STAT- MEDLINE
DCOM- 20230628
LR  - 20230628
IS  - 1003-0034 (Print)
IS  - 1003-0034 (Linking)
VI  - 36
IP  - 6
DP  - 2023 Jun 25
TI  - [Correlation between macrophage chemotaxis and disease severity in patients with 
      knee osteoarthritis].
PG  - 514-8
LID - 10.12200/j.issn.1003-0034.2023.06.004 [doi]
AB  - OBJECTIVE: To investigate the enhancement of macrophage chemotaxis in patients 
      with knee osteoarthritis (KOA) and its correlation with the disease severity. 
      METHODS: Eighty patients with KOA admitted from July 2019 to June 2022 were 
      enrolled as the observation group and divided into 29 cases of moderate group, 30 
      cases of severe group and 21 cases of extremely severe group. At the same time, 
      30 healthy subjects were included as the control group. The gene expressions of 
      NF-kappaB, CXC chemokine receptor 7 (CXCR7) and CXC chemokine ligand 12 (CXCL12) in 
      macrophages of each group were analyzed. Visual analogue scale(VAS) was used to 
      evaluate the degree of joint pain. Joint function was evaluated by knee Joint 
      Society Scoring system(KSS). Finally, data analysis was carried out. RESULTS: The 
      expression levels of NF-kappaB, CXCR7 and CXCL12 in moderate group, severe group and 
      extreme recombination group were higher than those in control group. The VAS, the 
      expression of NF-kappaB, CXCR7 and CXCL12 in the severe group and the extreme 
      recombination group were higher than those in the moderate group, whereas KSS was 
      lower than that in the moderate group. The VAS, expression levels of NF-kappaB, CXCR7 
      and CXCL12 in the extremely severe group were higher than those in the severe 
      group, and KSS was lower than that in the severe group (all P<0.01). The 
      expression levels of NF-kappaB, CXCR7 and CXCL12 in macrophages were positively 
      correlated with VAS score, but negatively correlated with KSS(all P<0.01). The 
      expression levels of NF-kappaB, CXCR7 and CXCL12 in macrophages were positively 
      correlated with the severity of disease. After excluding the influence of 
      traditional factors (gender, age and disease duration), multiple linear 
      regression analysis further showed that the expression levels of NF-kappaB, CXCR7 and 
      CXCL12 were still positively correlated with the severity of disease(all P<0.01). 
      CONCLUSION: The chemotaxis of macrophages in patients with KOA increased with the 
      aggravation of the disease, and was related to the degree of pain and function 
      impairment.
FAU - Xie, Zhi-Bo
AU  - Xie ZB
AD  - Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, 
      Guangdong, China.
FAU - Chen, Ke-Ming
AU  - Chen KM
AD  - Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, 
      Guangdong, China.
FAU - Huang, Cong-Wu
AU  - Huang CW
AD  - Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, 
      Guangdong, China.
FAU - Chen, Lin-Qing
AU  - Chen LQ
AD  - Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, 
      Guangdong, China.
FAU - Ouyang, Kai
AU  - Ouyang K
AD  - Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, 
      Guangdong, China.
FAU - Peng, Qing-Xing
AU  - Peng QX
AD  - Department of Second Orthopaedics, Fuyong People's Hospital, Shenzhen 518103, 
      Guangdong, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Gu Shang
JT  - Zhongguo gu shang = China journal of orthopaedics and traumatology
JID - 9815790
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, CXCR)
SB  - IM
MH  - Humans
MH  - *Osteoarthritis, Knee/genetics
MH  - Chemotaxis/genetics
MH  - NF-kappa B/genetics/metabolism
MH  - Macrophages/metabolism
MH  - *Receptors, CXCR/genetics/metabolism
MH  - Patient Acuity
OTO - NOTNLM
OT  - Chemotaxis
OT  - Correlation
OT  - Disease severity
OT  - Knee osteoarthritis
OT  - Macrophage
EDAT- 2023/06/27 06:42
MHDA- 2023/06/28 06:42
CRDT- 2023/06/27 05:43
PHST- 2023/06/28 06:42 [medline]
PHST- 2023/06/27 06:42 [pubmed]
PHST- 2023/06/27 05:43 [entrez]
AID - 10.12200/j.issn.1003-0034.2023.06.004 [doi]
PST - ppublish
SO  - Zhongguo Gu Shang. 2023 Jun 25;36(6):514-8. doi: 
      10.12200/j.issn.1003-0034.2023.06.004.