PMID- 37369261
OWN - NLM
STAT- MEDLINE
DCOM- 20230908
LR  - 20230908
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 43
DP  - 2023 Sep
TI  - A new perspective in the treatment follow-up of toxoplasma retinochoroiditis: 
      Infiltrate thickness measurement.
PG  - 103676
LID - S1572-1000(23)00403-9 [pii]
LID - 10.1016/j.pdpdt.2023.103676 [doi]
AB  - BACKGROUND: This study aimed to describe the spectral domain optical coherence 
      tomography (SD-OCT) findings of active lesions in toxoplasma retinochoroiditis 
      cases and to examine the changes in retinochoroidal infiltrate thickness after 
      treatment. METHODS: A total of 21 newly diagnosed patients with ocular 
      toxoplasmosis were included in this prospective study. A complete ophthalmologic 
      examination and SD-OCT were performed at the first visit. The patients were 
      followed up weekly, and the SD-OCT images were taken over the lesion at each 
      visit for 6 weeks. The characteristics of the active retinochoroiditis focus at 
      the first visit were determined, and the infiltrate thicknesses at all visits 
      were analyzed. RESULTS: A statistically significant BCVA difference was observed 
      at the first visit and at the last visit 6 weeks later (p < 0.01). The first week 
      after treatment showed a significant decrease in infiltrate thickness 
      (113.904 +/- 86.001 microm). In the following weeks, this decrease continued more 
      softly. The thickness change at 6 weeks was significantly reduced 
      (16.095 +/- 14.784 microm) compared with the previous ones. Weekly infitrate thickness 
      changes were compared among themselves; a statistically significant difference 
      was found between the 1st and 2nd weeks and the 5th and 6th weeks (p = 0.035 and 
      p = 0.007, respectively). Detached posterior vitreous in 71% (15/21) and 
      increased posterior vitreous thickness in 76% (16/21) of active lesion were 
      detected. All patients had 100% (21/21) increased retinal reflectivity and 
      disorganized retinal layers, and choroidal hypo-reflectivity was observed in 86% 
      (18/21). CONCLUSION: SD-OCT is a useful imaging modality in the diagnosis and 
      follow-up of ocular toxoplasmosis cases. Serial thickness measurements of 
      toxoplasma retinochoroiditis lesions may help confirm our diagnosis and determine 
      the need for treatment.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Mesen, Selma
AU  - Mesen S
AD  - Turkoglu Dr. Kemal Beyazit State Hospital, Ophthalmology Department. Electronic 
      address: drselmamesen@gmail.com.
FAU - Ozer, Muhammet Derda
AU  - Ozer MD
AD  - Yeni Yuzyil University, Gaziosmanpasa Hospital Ophthalmology Department. 
      Electronic address: muhammetderda@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230625
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Humans
MH  - *Toxoplasmosis, Ocular/diagnostic imaging/drug therapy
MH  - *Toxoplasma
MH  - Follow-Up Studies
MH  - Prospective Studies
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents/therapeutic use
MH  - Tomography, Optical Coherence/methods
OTO - NOTNLM
OT  - Infectious uveitis
OT  - Infiltrate thickness measurement
OT  - Retinal imaging
OT  - Spectral-domain optical coherence tomography
OT  - Toxoplasma retinochoroiditis
EDAT- 2023/06/28 01:06
MHDA- 2023/09/08 06:43
CRDT- 2023/06/27 19:10
PHST- 2023/04/18 00:00 [received]
PHST- 2023/06/23 00:00 [revised]
PHST- 2023/06/23 00:00 [accepted]
PHST- 2023/09/08 06:43 [medline]
PHST- 2023/06/28 01:06 [pubmed]
PHST- 2023/06/27 19:10 [entrez]
AID - S1572-1000(23)00403-9 [pii]
AID - 10.1016/j.pdpdt.2023.103676 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2023 Sep;43:103676. doi: 
      10.1016/j.pdpdt.2023.103676. Epub 2023 Jun 25.