PMID- 37371509
OWN - NLM
STAT- MEDLINE
DCOM- 20230629
LR  - 20230701
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 13
IP  - 6
DP  - 2023 Jun 1
TI  - Drug Delivery Systems for Personal Healthcare by Smart Wearable Patch System.
LID - 10.3390/biom13060929 [doi]
LID - 929
AB  - Smart wearable patch systems that combine biosensing and therapeutic components 
      have emerged as promising approaches for personalized healthcare and therapeutic 
      platforms that enable self-administered, noninvasive, user-friendly, and 
      long-acting smart drug delivery. Sensing components can continuously monitor 
      physiological and biochemical parameters, and the monitoring signals can be 
      transferred to various stimuli using actuators. In therapeutic components, 
      stimuli-responsive carrier-based drug delivery systems (DDSs) provide on-demand 
      drug delivery in a closed-loop manner. This review provides an overview of the 
      recent advances in smart wearable patch systems, focusing on sensing components, 
      stimuli, and therapeutic components. Additionally, this review highlights the 
      potential of fully integrated smart wearable patch systems for personalized 
      medicine. Furthermore, challenges associated with the clinical applications of 
      this system and future perspectives are discussed, including issues related to 
      drug loading and reloading, biocompatibility, accuracy of sensing and drug 
      delivery, and largescale fabrication.
FAU - Khadka, Bikram
AU  - Khadka B
AD  - Department of Biomedicine, Health & Life Convergence Sciences (BK21 Four), 
      Biomedical and Healthcare Research Institute (BHRI), Mokpo National University, 
      Muan-gun 58554, Jeonnam, Republic of Korea.
FAU - Lee, Byeongmoon
AU  - Lee B
AD  - Soft Hybrid Materials Research Center, Korea Institute of Science and Technology, 
      Seoul 02792, Republic of Korea.
FAU - Kim, Ki-Taek
AU  - Kim KT
AD  - Department of Biomedicine, Health & Life Convergence Sciences (BK21 Four), 
      Biomedical and Healthcare Research Institute (BHRI), Mokpo National University, 
      Muan-gun 58554, Jeonnam, Republic of Korea.
AD  - College of Pharmacy and Natural Medicine Research Institute, Mokpo National 
      University, Muan-gun 58554, Jeonnam, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230601
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Pharmaceutical Preparations
MH  - *Wearable Electronic Devices
MH  - Delivery of Health Care
PMC - PMC10295889
OTO - NOTNLM
OT  - biosensor
OT  - drug delivery systems
OT  - personalized healthcare
OT  - smart wearable patch
OT  - stimuli-responsive carriers
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/28 06:42
MHDA- 2023/06/29 06:43
PMCR- 2023/06/01
CRDT- 2023/06/28 01:07
PHST- 2023/04/27 00:00 [received]
PHST- 2023/05/28 00:00 [revised]
PHST- 2023/05/31 00:00 [accepted]
PHST- 2023/06/29 06:43 [medline]
PHST- 2023/06/28 06:42 [pubmed]
PHST- 2023/06/28 01:07 [entrez]
PHST- 2023/06/01 00:00 [pmc-release]
AID - biom13060929 [pii]
AID - biomolecules-13-00929 [pii]
AID - 10.3390/biom13060929 [doi]
PST - epublish
SO  - Biomolecules. 2023 Jun 1;13(6):929. doi: 10.3390/biom13060929.