PMID- 37371822
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230701
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 6
DP  - 2023 Jun 16
TI  - Current State and Prospectives for Proton Boron Capture Therapy.
LID - 10.3390/biomedicines11061727 [doi]
LID - 1727
AB  - The development of new methods increasing the biological effectiveness of proton 
      therapy (PT) is of high interest in radiation oncology. The use of binary 
      technologies, in which the damaging effect of proton radiation is further 
      enhanced by the selective accumulation of the radiosensitizer in the target 
      tissue, can significantly increase the effectiveness of radiation therapy. To 
      increase the absorbed dose in a tumor target, proton boron capture therapy (PBCT) 
      was proposed based on the reaction of proton capture on the (11)B isotope with 
      the formation of three alpha-particles. This review summarizes data on theoretical 
      and experimental studies on the effectiveness and prospects of proton boron 
      capture therapy.
FAU - Tran, Nhan Hau
AU  - Tran NH
AD  - Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National 
      Research Centre <<Kurchatov Institute>>, Orlova roscha 1, Gatchina 188300, Russia.
AD  - Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg 
      Polytechnic University, Politehnicheskaya 29, St. Petersburg 195251, Russia.
FAU - Shtam, Tatiana
AU  - Shtam T
AUID- ORCID: 0000-0003-0651-4785
AD  - Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National 
      Research Centre <<Kurchatov Institute>>, Orlova roscha 1, Gatchina 188300, Russia.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova pl. 1, 
      Moscow 123182, Russia.
FAU - Marchenko, Yaroslav Yu
AU  - Marchenko YY
AD  - Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National 
      Research Centre <<Kurchatov Institute>>, Orlova roscha 1, Gatchina 188300, Russia.
FAU - Konevega, Andrey L
AU  - Konevega AL
AUID- ORCID: 0000-0003-0125-7150
AD  - Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National 
      Research Centre <<Kurchatov Institute>>, Orlova roscha 1, Gatchina 188300, Russia.
AD  - Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg 
      Polytechnic University, Politehnicheskaya 29, St. Petersburg 195251, Russia.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova pl. 1, 
      Moscow 123182, Russia.
FAU - Lebedev, Dmitry
AU  - Lebedev D
AUID- ORCID: 0000-0003-4313-9953
AD  - Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National 
      Research Centre <<Kurchatov Institute>>, Orlova roscha 1, Gatchina 188300, Russia.
AD  - National Research Center "Kurchatov Institute", Akademika Kurchatova pl. 1, 
      Moscow 123182, Russia.
LA  - eng
GR  - 075-15-2021-1360/Ministry of Science and Higher Education of the Russian 
      Federation/
PT  - Journal Article
PT  - Review
DEP - 20230616
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC10296516
OTO - NOTNLM
OT  - proton boron capture therapy
OT  - proton therapy
OT  - radiotherapy
OT  - sensitization
COIS- The authors declare there are no conflict of interest.
EDAT- 2023/06/28 06:42
MHDA- 2023/06/28 06:43
PMCR- 2023/06/16
CRDT- 2023/06/28 01:09
PHST- 2022/12/26 00:00 [received]
PHST- 2023/05/19 00:00 [revised]
PHST- 2023/06/11 00:00 [accepted]
PHST- 2023/06/28 06:43 [medline]
PHST- 2023/06/28 06:42 [pubmed]
PHST- 2023/06/28 01:09 [entrez]
PHST- 2023/06/16 00:00 [pmc-release]
AID - biomedicines11061727 [pii]
AID - biomedicines-11-01727 [pii]
AID - 10.3390/biomedicines11061727 [doi]
PST - epublish
SO  - Biomedicines. 2023 Jun 16;11(6):1727. doi: 10.3390/biomedicines11061727.