PMID- 37371979
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230701
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 12
IP  - 6
DP  - 2023 Jun 9
TI  - The Effect of Astaxanthin on Mitochondrial Dynamics in Rat Heart Mitochondria 
      under ISO-Induced Injury.
LID - 10.3390/antiox12061247 [doi]
LID - 1247
AB  - Mitochondria are dynamic organelles that produce ATP in the cell and are 
      sensitive to oxidative damage that impairs mitochondrial function in pathological 
      conditions. Mitochondria are involved not only in a healthy heart but also in the 
      development of heart disease. Therefore, attempts should be made to enhance the 
      body's defense response against oxidative stress with the help of various 
      antioxidants in order to decrease mitochondrial damage and reduce mitochondrial 
      dysfunction. Mitochondrial fission and fusion play an important role in the 
      quality control and maintenance of mitochondria. The ketocarotenoid astaxanthin 
      (AX) is an antioxidant able to maintain mitochondrial integrity and prevent 
      oxidative stress. In the present study, we investigated the effect of the 
      protective effect of AX on the functioning of rat heart mitochondria (RHM). 
      Changes in the content of proteins responsible for mitochondrial dynamics, 
      prohibitin 2 (PHB2) as a protein that performs the function of quality control of 
      mitochondrial proteins and participates in the stabilization of mitophagy, and 
      changes in the content of cardiolipin (CL) in rat heart mitochondria after 
      isoproterenol (ISO)-induced damage were examined. AX improved the respiratory 
      control index (RCI), enhanced mitochondrial fusion, and inhibited mitochondrial 
      fission in RHM after ISO injury. Rat heart mitochondria (RHM) were more 
      susceptible to Ca(2+)-induced mitochondrial permeability pore (mPTP) opening 
      after ISO injection, while AX abolished the effect of ISO. AX is able to perform 
      a protective function in mitochondria, improving their efficiency. Therefore, AX 
      can be considered an important ingredient in the diet for the prevention of 
      cardiovascular disease. Therefore, AX can be examined as an important component 
      of the diet for the prevention of heart disease.
FAU - Krestinin, Roman
AU  - Krestinin R
AD  - Institute of Theoretical and Experimental Biophysics, Russian Academy of 
      Sciences, 142290 Pushchino, Moscow Region, Russia.
FAU - Baburina, Yulia
AU  - Baburina Y
AD  - Institute of Theoretical and Experimental Biophysics, Russian Academy of 
      Sciences, 142290 Pushchino, Moscow Region, Russia.
FAU - Odinokova, Irina
AU  - Odinokova I
AUID- ORCID: 0000-0002-6331-0191
AD  - Institute of Theoretical and Experimental Biophysics, Russian Academy of 
      Sciences, 142290 Pushchino, Moscow Region, Russia.
FAU - Kruglov, Alexey
AU  - Kruglov A
AUID- ORCID: 0000-0001-9215-7387
AD  - Institute of Theoretical and Experimental Biophysics, Russian Academy of 
      Sciences, 142290 Pushchino, Moscow Region, Russia.
FAU - Sotnikova, Linda
AU  - Sotnikova L
AD  - Institute of Theoretical and Experimental Biophysics, Russian Academy of 
      Sciences, 142290 Pushchino, Moscow Region, Russia.
FAU - Krestinina, Olga
AU  - Krestinina O
AD  - Institute of Theoretical and Experimental Biophysics, Russian Academy of 
      Sciences, 142290 Pushchino, Moscow Region, Russia.
LA  - eng
GR  - No. 075-01025-23-01/the framework of the state assignment/
PT  - Journal Article
DEP - 20230609
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC10295417
OTO - NOTNLM
OT  - ISO-induced damage
OT  - fission
OT  - fusion
OT  - mytophagy
OT  - oxidative stress
OT  - rat heart mitochondria
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/28 06:43
MHDA- 2023/06/28 06:44
PMCR- 2023/06/09
CRDT- 2023/06/28 01:10
PHST- 2023/04/04 00:00 [received]
PHST- 2023/06/06 00:00 [revised]
PHST- 2023/06/07 00:00 [accepted]
PHST- 2023/06/28 06:44 [medline]
PHST- 2023/06/28 06:43 [pubmed]
PHST- 2023/06/28 01:10 [entrez]
PHST- 2023/06/09 00:00 [pmc-release]
AID - antiox12061247 [pii]
AID - antioxidants-12-01247 [pii]
AID - 10.3390/antiox12061247 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2023 Jun 9;12(6):1247. doi: 10.3390/antiox12061247.