PMID- 37372389
OWN - NLM
STAT- MEDLINE
DCOM- 20230629
LR  - 20230701
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 14
IP  - 6
DP  - 2023 May 31
TI  - Associations between Lipid Profiles and Graves' Orbitopathy can Be HLA-Dependent.
LID - 10.3390/genes14061209 [doi]
LID - 1209
AB  - The risk of Graves' orbitopathy (GO) is related to the human leukocyte antigen 
      (HLA) profile and was demonstrated to be increased in patients with elevated 
      total cholesterol (TC) and/or low-density lipoprotein (LDL) cholesterol. We 
      hypothesized that there were some HLA alleles that were related to both GO and TC 
      and/or LDL levels. Therefore, the aim of the study was to compare the TC/LDL 
      results in patients in whom GO-related HLA alleles were present to those in whom 
      they did not occur. HLA classes were genotyped using a next-generation sequencing 
      method in 118 patients with Graves' disease (GD), including 63 and 55 patients 
      with and without GO, respectively. Lipid profiles were assessed at the time of 
      the GD diagnosis. A significant correlation between the presence of GO high-risk 
      alleles (HLA-B*37:01 and C*03:02) and higher TC/LDL levels was found. 
      Additionally, the presence of alleles associated with non-GO GD (HLA-C*17:01 and 
      B*08:01), as well as alleles in linkage disequilibrium with B*08:01 (i.e., 
      HLA-DRB1*03:01 and DQB1*02:01), was correlated with lower TC levels. These 
      results further confirm the significance of TC/LDL in the risk of GO development 
      and provide evidence that associations between TC/LDL and GO can be 
      HLA-dependent.
FAU - Stasiak, Magdalena
AU  - Stasiak M
AUID- ORCID: 0000-0002-2910-7691
AD  - Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial 
      Hospital-Research Institute, 281/289 Rzgowska St., 93-338 Lodz, Poland.
FAU - Zawadzka-Starczewska, Katarzyna
AU  - Zawadzka-Starczewska K
AD  - Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial 
      Hospital-Research Institute, 281/289 Rzgowska St., 93-338 Lodz, Poland.
FAU - Tymoniuk, Boguslaw
AU  - Tymoniuk B
AD  - Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, 
      251 Pomorska St., 92-213 Lodz, Poland.
FAU - Stasiak, Bartlomiej
AU  - Stasiak B
AD  - Institute of Information Technology, Lodz University of Technology, 215 
      Wolczanska St., 90-924 Lodz, Poland.
FAU - Lewinski, Andrzej
AU  - Lewinski A
AUID- ORCID: 0000-0002-8748-3337
AD  - Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial 
      Hospital-Research Institute, 281/289 Rzgowska St., 93-338 Lodz, Poland.
AD  - Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 
      281/289 Rzgowska St., 93-338 Lodz, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230531
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Proteins)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 0 (Lipids)
SB  - IM
MH  - Humans
MH  - *Graves Ophthalmopathy/genetics/diagnosis
MH  - *Graves Disease
MH  - HLA-DRB1 Chains
MH  - Proteins
MH  - Cholesterol
MH  - Lipids/genetics
PMC - PMC10298599
OTO - NOTNLM
OT  - Graves' disease
OT  - Graves' orbitopathy
OT  - HLA
OT  - LDL cholesterol
OT  - TSH receptor antibodies
OT  - human leukocyte antigen
OT  - risk factors
OT  - total cholesterol
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/28 06:42
MHDA- 2023/06/29 06:43
PMCR- 2023/05/31
CRDT- 2023/06/28 01:12
PHST- 2023/04/12 00:00 [received]
PHST- 2023/05/22 00:00 [revised]
PHST- 2023/05/29 00:00 [accepted]
PHST- 2023/06/29 06:43 [medline]
PHST- 2023/06/28 06:42 [pubmed]
PHST- 2023/06/28 01:12 [entrez]
PHST- 2023/05/31 00:00 [pmc-release]
AID - genes14061209 [pii]
AID - genes-14-01209 [pii]
AID - 10.3390/genes14061209 [doi]
PST - epublish
SO  - Genes (Basel). 2023 May 31;14(6):1209. doi: 10.3390/genes14061209.