PMID- 37373916
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230701
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 13
IP  - 6
DP  - 2023 May 31
TI  - Long-Term Care and Follow-Up in Laryngeal Cancer Patients: A Multicenter 
      Retrospective Analysis.
LID - 10.3390/jpm13060927 [doi]
LID - 927
AB  - PURPOSE: We conducted an outcome analysis on surgically treated laryngeal 
      squamous cell carcinoma (LSCC) patients. METHODS: A multicenter retrospective 
      study with 352 patients was analyzed. A new nomogram that incorporates age, T- 
      and N-classification, and treatment was created. RESULTS: Recurrence was observed 
      in 65 (18.5%) patients after a mean time of 16.5 months. After 60 months, 91 
      (25.9%) of patients developed secondary primary tumors (SPT), most commonly in 
      the lungs (n = 29; 8.2%) followed by other head and neck cancers (n = 21; 6.0%). 
      Notably, the mean time to occurrence of secondary head and neck cancers was twice 
      that of lung cancer (101.1 vs. 47.5 months). CONCLUSION: Recurrent disease is 
      less common in LSCC patients and appears much earlier than SPT. Because one in 
      every four laryngeal cancer patients develops SPTs within 5-10 years, long-term 
      care and follow-up, including imaging studies, are highly recommended. The 
      nomogram was useful for estimating survival.
FAU - Marijic, Blazen
AU  - Marijic B
AUID- ORCID: 0000-0001-6094-7114
AD  - Institute of Head and Neck Diseases, Evangelical Hospital, 1180 Vienna, Austria.
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital 
      Center Rijeka, 51000 Rijeka, Croatia.
AD  - Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
FAU - Tudor, Filip
AU  - Tudor F
AUID- ORCID: 0000-0001-6386-0444
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital 
      Center Rijeka, 51000 Rijeka, Croatia.
AD  - Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
FAU - Janik, Stefan
AU  - Janik S
AUID- ORCID: 0000-0002-1161-4871
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University 
      Vienna, 1090 Vienna, Austria.
FAU - Grasl, Stefan
AU  - Grasl S
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University 
      Vienna, 1090 Vienna, Austria.
FAU - Frommlet, Florian
AU  - Frommlet F
AD  - Center for Medical Statistics, Informatics and Intelligent Systems, Section for 
      Medical Statistics, Medical University Vienna, 1090 Vienna, Austria.
FAU - Marzic, Diana
AU  - Marzic D
AD  - Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
AD  - Department of Audiology and Phoniatrics, Clinical Hospital Centre Rijeka, 51000 
      Rijeka, Croatia.
FAU - Hadzisejdic, Ita
AU  - Hadzisejdic I
AUID- ORCID: 0000-0003-1800-3552
AD  - Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
AD  - Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, 
      51000 Rijeka, Croatia.
FAU - Vukelic, Jelena
AU  - Vukelic J
AD  - Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
AD  - Department of Audiology and Phoniatrics, Clinical Hospital Centre Rijeka, 51000 
      Rijeka, Croatia.
FAU - Braut, Tamara
AU  - Braut T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital 
      Center Rijeka, 51000 Rijeka, Croatia.
AD  - Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
FAU - Velepic, Marko
AU  - Velepic M
AUID- ORCID: 0000-0002-9826-798X
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital 
      Center Rijeka, 51000 Rijeka, Croatia.
AD  - Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
FAU - Erovic, Boban M
AU  - Erovic BM
AUID- ORCID: 0000-0001-5706-1056
AD  - Institute of Head and Neck Diseases, Evangelical Hospital, 1180 Vienna, Austria.
LA  - eng
PT  - Journal Article
DEP - 20230531
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC10302671
OTO - NOTNLM
OT  - laryngeal carcinoma
OT  - long-term care and follow-up
OT  - recurrence
OT  - secondary primary tumor
OT  - survival
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/28 06:42
MHDA- 2023/06/28 06:43
PMCR- 2023/05/31
CRDT- 2023/06/28 01:23
PHST- 2023/05/14 00:00 [received]
PHST- 2023/05/29 00:00 [revised]
PHST- 2023/05/30 00:00 [accepted]
PHST- 2023/06/28 06:43 [medline]
PHST- 2023/06/28 06:42 [pubmed]
PHST- 2023/06/28 01:23 [entrez]
PHST- 2023/05/31 00:00 [pmc-release]
AID - jpm13060927 [pii]
AID - jpm-13-00927 [pii]
AID - 10.3390/jpm13060927 [doi]
PST - epublish
SO  - J Pers Med. 2023 May 31;13(6):927. doi: 10.3390/jpm13060927.