PMID- 37374276
OWN - NLM
STAT- MEDLINE
DCOM- 20230629
LR  - 20230701
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 6
DP  - 2023 Jun 2
TI  - The Follicular Dendritic Cells and HPV 18 Interrelation in Head and Neck Squamous 
      Cell Carcinomas of the Larynx.
LID - 10.3390/medicina59061072 [doi]
LID - 1072
AB  - Background and Objectives: Even if they are cells of controversial origin 
      (mesenchymal, perivascular, or fibroblastic), follicular dendritic cells (FDC) 
      are present in all organs. The aim of this study was to establish the FDC 
      expression pattern and its interrelation with HPV 18 expression in laryngeal 
      squamous cell carcinoma (LSCC). Materials and Methods: Fifty-six cases of LSCC 
      were evaluated by simple and double immunostaining. The following score was used: 
      0 (negative or few positive cells), 1 (10-30% of positive cells), 2 (30-50% of 
      cells), and 3 (over 50% of cells). Results: The expression of CD 21-positive 
      cells with dendritic morphology (CDM) was noticed in the intratumoral area of 
      conventional (well and poorly differentiated types and HPV 18 positive cases with 
      a value of 2 for the score) and papillary types (HPV-18 negative cases with a 
      score of 1). The highest value of 2 for the score of CDM in HPV-18 positive cases 
      was found in the peritumoral area of well- and poorly-differentiated conventional 
      LSCCs. A significant correlation was found between scores of CDM from the 
      intratumoral area and those of the peritumoral area (p = 0.001), between CDM and 
      non-dendritic morphology cells (NDM) of the intratumoral area (p = 0.001), and 
      between HPV-18 status and peritumoral NDM cells (p = 0.044). Conclusions: The FDC 
      and NDM cell score values of intratumoral and peritumoral areas may represent 
      important parameters of LSCCs. This may contribute to a better stratification of 
      laryngeal carcinoma cases and the individualized selection of clinical treatment 
      protocols.
FAU - Boia, Eugen Radu
AU  - Boia ER
AD  - Department of ENT, Faculty of Medicine, Victor Babes University of Medicine and 
      Pharmacy, 300041 Timisoara, Romania.
FAU - Boia, Simina
AU  - Boia S
AD  - Department of Periodontology, Faculty of Dental Medicine, Victor Babes University 
      of Medicine and Pharmacy, 300041 Timisoara, Romania.
FAU - Ceausu, Raluca Amalia
AU  - Ceausu RA
AUID- ORCID: 0000-0002-0067-8247
AD  - Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 
      Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
FAU - Gaje, Pusa Nela
AU  - Gaje PN
AD  - Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 
      Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
FAU - Maaroufi, Sarrah Mariam
AU  - Maaroufi SM
AD  - Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 
      Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
FAU - Sandru, Florica
AU  - Sandru F
AD  - Department of Dermatovenerology, "Carol Davila" of Medicine and Pharmacy, 050474 
      Bucharest, Romania.
AD  - Department of Dermatology, Elias University Emergency Hospital, 011461 Bucharest, 
      Romania.
FAU - Raica, Marius
AU  - Raica M
AD  - Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 
      Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
LA  - eng
GR  - research internal funds./Victor Babes University of Medicine and Pharmacy 
      Timisoara/
PT  - Journal Article
DEP - 20230602
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Humans
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Human papillomavirus 18
MH  - *Carcinoma, Squamous Cell/pathology
MH  - Dendritic Cells, Follicular/metabolism/pathology
MH  - *Papillomavirus Infections
MH  - *Larynx/metabolism/pathology
MH  - *Head and Neck Neoplasms
PMC - PMC10302899
OTO - NOTNLM
OT  - HPV-18
OT  - follicular dendritic cells
OT  - larynx
OT  - squamous cell carcinoma
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/28 06:42
MHDA- 2023/06/29 06:43
PMCR- 2023/06/02
CRDT- 2023/06/28 01:25
PHST- 2023/03/27 00:00 [received]
PHST- 2023/05/28 00:00 [revised]
PHST- 2023/05/29 00:00 [accepted]
PHST- 2023/06/29 06:43 [medline]
PHST- 2023/06/28 06:42 [pubmed]
PHST- 2023/06/28 01:25 [entrez]
PHST- 2023/06/02 00:00 [pmc-release]
AID - medicina59061072 [pii]
AID - medicina-59-01072 [pii]
AID - 10.3390/medicina59061072 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Jun 2;59(6):1072. doi: 10.3390/medicina59061072.