PMID- 37374299
OWN - NLM
STAT- MEDLINE
DCOM- 20230629
LR  - 20230701
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 6
DP  - 2023 Jun 6
TI  - Sarcopenia with Depression Presents a More Severe Disability Than Only Sarcopenia 
      among Japanese Older Adults in Need of Long-Term Care.
LID - 10.3390/medicina59061095 [doi]
LID - 1095
AB  - Background and objectives: The combination of depression and sarcopenia, a 
      condition prevalent worldwide, may cause dis-tinct problems that should not be 
      underestimated. However, to the best of our knowledge, no reports have 
      investigated the combined effects of depression and sarcopenia. In this study, we 
      compared physical function, nutritional status, and daily functioning among older 
      adults with only depression (OD), those with only sarcopenia (OS), and those with 
      sarcopenia with depression (SD) to examine the effects of the combination of 
      depression and sarcopenia. Materials and Methods: The participants were 186 
      communi-ty-dwelling older individuals who required support or care. The 
      participants were classified into four groups based on the presence or absence of 
      sarcopenia and depression: Control, OD, OS, and SD. The following parameters were 
      evaluated in the four groups: grip strength, walking speed, skeletal muscle mass 
      index (SMI), Mini Nutritional Assessment Short-Form (MNA-sf), and long-term care 
      certification level. In addition, univariate and multivariate analyses of the 
      survey results were performed to identify risk factors leading from OS to SD. 
      Results: We found that 31.2% of older participants who needed support or nursing 
      care had SD, which had more pronounced adverse effects on grip strength, walking 
      speed, SMI, MNA-sf, and level of nursing care than OD or OS. Furthermore, 
      multivariate analysis of SD vs. OS showed that decreased grip strength and 
      worsening MNA-sf were independent risk factors. Conclusions: SD is common among 
      older individuals living in the community. Patients with SD require support and 
      care, and the condition has a greater impact on physical function, nutritional 
      status, and decline in life function compared to OD and OS. Therefore, it is 
      desirable to elucidate the process leading to SD and investigate the risk factors 
      and prognosis. It is expected that sarcopenia with depression will be 
      investigated worldwide in the future.
FAU - Shiba, Takahiro
AU  - Shiba T
AD  - Nishinasuno General Home Care Center, Department of Day Rehabilitation, Care 
      Facility for the Elderly "Maronie-en," 533-11 Iguchi, Nasushiobara 329-2763, 
      Tochigi, Japan.
FAU - Sato, Ryo
AU  - Sato R
AD  - Nishinasuno General Home Care Center, Department of Day Rehabilitation, Care 
      Facility for the Elderly "Maronie-en," 533-11 Iguchi, Nasushiobara 329-2763, 
      Tochigi, Japan.
FAU - Sawaya, Yohei
AU  - Sawaya Y
AUID- ORCID: 0000-0001-5679-2391
AD  - Nishinasuno General Home Care Center, Department of Day Rehabilitation, Care 
      Facility for the Elderly "Maronie-en," 533-11 Iguchi, Nasushiobara 329-2763, 
      Tochigi, Japan.
AD  - Department of Physical Therapy, School of Health Sciences, International 
      University of Health and Welfare, 2600-1 Kitakanemaru, Otawara 324-8501, Tochigi, 
      Japan.
FAU - Hirose, Tamaki
AU  - Hirose T
AUID- ORCID: 0000-0002-0774-5051
AD  - Nishinasuno General Home Care Center, Department of Day Rehabilitation, Care 
      Facility for the Elderly "Maronie-en," 533-11 Iguchi, Nasushiobara 329-2763, 
      Tochigi, Japan.
AD  - Department of Physical Therapy, School of Health Sciences, International 
      University of Health and Welfare, 2600-1 Kitakanemaru, Otawara 324-8501, Tochigi, 
      Japan.
FAU - Ishizaka, Masahiro
AU  - Ishizaka M
AD  - Department of Physical Therapy, School of Health Sciences, International 
      University of Health and Welfare, 2600-1 Kitakanemaru, Otawara 324-8501, Tochigi, 
      Japan.
FAU - Kubo, Akira
AU  - Kubo A
AD  - Department of Physical Therapy, School of Health Sciences, International 
      University of Health and Welfare, 2600-1 Kitakanemaru, Otawara 324-8501, Tochigi, 
      Japan.
FAU - Urano, Tomohiko
AU  - Urano T
AD  - Nishinasuno General Home Care Center, Department of Day Rehabilitation, Care 
      Facility for the Elderly "Maronie-en," 533-11 Iguchi, Nasushiobara 329-2763, 
      Tochigi, Japan.
AD  - Department of Geriatric Medicine, School of Medicine, International University of 
      Health and Welfare, 4-3 Kozunomori, Narita 286-8686, Chiba, Japan.
LA  - eng
GR  - 22K17539/Japan Society for the Promotion of Science/
GR  - 20K07789/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20230606
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Sarcopenia/complications
MH  - Long-Term Care
MH  - Depression/complications
MH  - East Asian People
MH  - Hand Strength
PMC - PMC10301151
OTO - NOTNLM
OT  - long-term care certification level
OT  - nutrition
OT  - older adults
OT  - physical function
OT  - sarcopenia with depression
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/28 06:42
MHDA- 2023/06/29 06:43
PMCR- 2023/06/06
CRDT- 2023/06/28 01:25
PHST- 2023/04/11 00:00 [received]
PHST- 2023/05/30 00:00 [revised]
PHST- 2023/06/02 00:00 [accepted]
PHST- 2023/06/29 06:43 [medline]
PHST- 2023/06/28 06:42 [pubmed]
PHST- 2023/06/28 01:25 [entrez]
PHST- 2023/06/06 00:00 [pmc-release]
AID - medicina59061095 [pii]
AID - medicina-59-01095 [pii]
AID - 10.3390/medicina59061095 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Jun 6;59(6):1095. doi: 10.3390/medicina59061095.