PMID- 37376336 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230701 IS - 2073-4360 (Electronic) IS - 2073-4360 (Linking) VI - 15 IP - 12 DP - 2023 Jun 15 TI - A Regression Approach to Model Refractive Index Measurements of Novel 3D Printable Photocurable Resins for Micro-Optofluidic Applications. LID - 10.3390/polym15122690 [doi] LID - 2690 AB - In this work, a quadratic polynomial regression model was developed to aid practitioners in the determination of the refractive index value of transparent 3D printable photocurable resins usable for micro-optofluidic applications. The model was experimentally determined by correlating empirical optical transmission measurements (the dependent variable) to known refractive index values (the independent variable) of photocurable materials used in optics, thus obtaining a related regression equation. In detail, a novel, simple, and cost-effective experimental setup is proposed in this study for the first time for collecting the transmission measurements of smooth 3D printed samples (roughness ranging between 0.04 and 2 mum). The model was further used to determine the unknown refractive index value of novel photocurable resins applicable in vat photopolymerization (VP) 3D printing techniques for manufacturing micro-optofluidic (MoF) devices. In the end, this study proved how knowledge of this parameter allowed us to compare and interpret collected empirical optical data from microfluidic devices made of more traditional materials, i.e., Poly(dimethylsiloxane) (PDMS), up to novel 3D printable photocurable resins suitable for biological and biomedical applications. Thus, the developed model also provides a quick method to evaluate the suitability of novel 3D printable resins for MoF device fabrication within a well-defined range of refractive index values (1.56; 1.70). FAU - Saitta, Lorena AU - Saitta L AUID- ORCID: 0000-0002-1423-8779 AD - Department of Civil Engineering and Architecture, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy. FAU - Cutuli, Emanuela AU - Cutuli E AD - Department of Electrical Electronic and Computer Science Engineering, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy. FAU - Celano, Giovanni AU - Celano G AUID- ORCID: 0000-0001-7871-7499 AD - Department of Civil Engineering and Architecture, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy. FAU - Tosto, Claudio AU - Tosto C AUID- ORCID: 0000-0001-6814-7293 AD - Department of Civil Engineering and Architecture, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy. FAU - Stella, Giovanna AU - Stella G AD - Department of Electrical Electronic and Computer Science Engineering, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy. FAU - Cicala, Gianluca AU - Cicala G AUID- ORCID: 0000-0002-4680-152X AD - Department of Civil Engineering and Architecture, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy. AD - INSTM-UDR CT, Viale Andrea Doria 6, 95125 Catania, Italy. FAU - Bucolo, Maide AU - Bucolo M AUID- ORCID: 0000-0003-4867-0620 AD - Department of Electrical Electronic and Computer Science Engineering, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy. LA - eng GR - MUR-PNRR project SAMOTHRACE (ECS00000022)/European Union (NextGeneration EU)/ GR - under the grant scheme PIACERI with project MAF-moF "Materiali multifunzionali per dispositivi micro-optofluidici"/University of Catania/ PT - Journal Article DEP - 20230615 PL - Switzerland TA - Polymers (Basel) JT - Polymers JID - 101545357 PMC - PMC10301409 OTO - NOTNLM OT - 3D printing OT - micro-optics OT - microfluidics OT - photocurable resin OT - refractive index measurement OT - vat-photopolymerization COIS- The authors declare no conflict of interest. EDAT- 2023/06/28 06:42 MHDA- 2023/06/28 06:43 PMCR- 2023/06/15 CRDT- 2023/06/28 01:38 PHST- 2023/05/10 00:00 [received] PHST- 2023/06/05 00:00 [revised] PHST- 2023/06/13 00:00 [accepted] PHST- 2023/06/28 06:43 [medline] PHST- 2023/06/28 06:42 [pubmed] PHST- 2023/06/28 01:38 [entrez] PHST- 2023/06/15 00:00 [pmc-release] AID - polym15122690 [pii] AID - polymers-15-02690 [pii] AID - 10.3390/polym15122690 [doi] PST - epublish SO - Polymers (Basel). 2023 Jun 15;15(12):2690. doi: 10.3390/polym15122690.