PMID- 37378216 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230701 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 15 IP - 5 DP - 2023 May TI - A Joint Saga: Human Leukocyte Antigen (HLA) B27 Ankylosing Spondylitis and Sacroiliitis Association with Henoch-Schonlein Purpura. PG - e39041 LID - 10.7759/cureus.39041 [doi] LID - e39041 AB - Henoch-Schonlein purpura (HSP) or IgA vasculitis is a small-vessel vasculitis mediated by IgA deposition, often associated with upper respiratory tract infection and family history. However, there is a rare correlation to human leukocyte antigen (HLA) B27 arthropathy. We present a case of a young boy diagnosed with HSP suffering from arthritis, gait disturbance, and weakness throughout childhood, ultimately diagnosed with ankylosing spondylitis and sacroiliitis clinically, with confirmation through X-ray and supporting HLA B27 testing. CI - Copyright (c) 2023, Nassif et al. FAU - Nassif, Nicholas D AU - Nassif ND AD - Internal Medicine, Advocate Aurora Healthcare, Milwaukee, USA. FAU - Rosler, Daniel AU - Rosler D AD - Rheumatology, Advocate Aurora Healthcare, Milwaukee, USA. LA - eng PT - Case Reports DEP - 20230515 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC10291992 OTO - NOTNLM OT - ankylosis spondylitis OT - henoch-schonlein purpura OT - hla OT - iga OT - vasculitis COIS- The authors have declared that no competing interests exist. EDAT- 2023/06/28 13:09 MHDA- 2023/06/28 13:10 PMCR- 2023/05/15 CRDT- 2023/06/28 09:29 PHST- 2023/05/15 00:00 [accepted] PHST- 2023/06/28 13:10 [medline] PHST- 2023/06/28 13:09 [pubmed] PHST- 2023/06/28 09:29 [entrez] PHST- 2023/05/15 00:00 [pmc-release] AID - 10.7759/cureus.39041 [doi] PST - epublish SO - Cureus. 2023 May 15;15(5):e39041. doi: 10.7759/cureus.39041. eCollection 2023 May.