PMID- 37378849
OWN - NLM
STAT- MEDLINE
DCOM- 20230905
LR  - 20230905
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 43
IP  - 7
DP  - 2023 Oct
TI  - Leptin Signaling Could Mediate Hippocampal Decumulation of Beta-Amyloid and Tau 
      Induced by High-Intensity Interval Training in Rats with Type 2 Diabetes.
PG  - 3465-3478
LID - 10.1007/s10571-023-01357-1 [doi]
AB  - Leptin (LEP) can cross the blood-brain barrier and facilitate cross-talk between 
      the adipose tissue and central nerve system (CNS). This study aimed to 
      investigate the effect of 8-week high-intensity interval training (HIIT) on the 
      LEP signaling in the hippocampus of rats with type 2 diabetes. 20 rats were 
      randomly divided into four groups: (i) control (Con), (ii) type 2 diabetes (T2D), 
      (iii) exercise (EX), and (iv) type 2 diabetes + exercise (T2D + EX). The rats in 
      the T2D and T2D + EX were fed a high-fat diet for two months, then a single dose 
      of STZ (35 mg/kg) was injected to induce diabetes. The EX and T2D + EX groups 
      performed 4-10 intervals of treadmill running at 80-100% of V(max). Serum and 
      hippocampal levels of LEP as well as hippocampal levels of LEP receptors (LEP-R), 
      Janus kinase 2 (JAK-2), signal transducer and activator of transcription 3 
      (STAT-3), activated protein kinase (AMP-K), proxy zoster receptor alpha (PGC-1alpha), 
      beta-secretase 1 (BACE1), Beta-Amyloid (Abeta), Phosphoinositide 3-kinases (PI3K), 
      protein kinase B (AKT), mammalian target of rapamycin (mTOR), Glycogen Synthase 
      Kinase 3 Beta (GSK3beta), and hyperphosphorylated tau proteins (TAU) were measured. 
      One-way ONOVA and Tukey post-hoc tests were used to analyze the data. Serum and 
      hippocampal levels of LEP as well as hippocampal levels of LEP-R, JAK-2, STAT-3, 
      AMP-K, PGC1alpha, PI3K, AKT, and mTOR were increased while hippocampal levels of 
      BACE1, GSK3B, TAU, and Abeta were decreased in T2D + EX compared with T2D group. 
      Serum LEP and hippocampal levels of LEP, LEP-R, JAK-2, STAT-3, AMP-K, PGC1alpha, 
      PI3K, AKT, and mTOR were decreased. Conversely hippocampal levels of BACE1, 
      GSK3B, TAU, and Abeta were increased in T2D group compared with CON group. HIIT 
      could improve LEP signaling in the hippocampus of rats with type 2 diabetes and 
      decrease the accumulation of Tau and Abeta, which may reduce the risk of memory 
      impairments.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Rezaei, Maryam Hossein
AU  - Rezaei MH
AD  - Department of Exercise Physiology, Faculty of Physical Education, Shahid Bahonar 
      University, Kerman, Iran.
FAU - Madadizadeh, Elham
AU  - Madadizadeh E
AD  - Department of Exercise Physiology, Faculty of Physical Education, Shahid Bahonar 
      University, Kerman, Iran.
FAU - Aminaei, Mohsen
AU  - Aminaei M
AD  - Department of Exercise Physiology, Faculty of Physical Education, Shahid Bahonar 
      University, Kerman, Iran.
FAU - Abbaspoor, Mehdi
AU  - Abbaspoor M
AD  - Department of Exercise Physiology, Faculty of Physical Education, Shahid Bahonar 
      University, Kerman, Iran.
FAU - Schierbauer, Janis
AU  - Schierbauer J
AD  - Exercise Physiology and Metabolism (Sports Medicine), BaySpo-Bayreuth Centre of 
      Sports Science, University of Bayreuht, Bayreuth, Germany.
FAU - Moser, Othmar
AU  - Moser O
AD  - Exercise Physiology and Metabolism (Sports Medicine), BaySpo-Bayreuth Centre of 
      Sports Science, University of Bayreuht, Bayreuth, Germany.
AD  - Interdisciplinary Metabolic Medicine Trials Unit, Medical University of Graz, 
      Graz, Austria.
FAU - Khoramipour, Kayvan
AU  - Khoramipour K
AD  - Neuroscience Research Center, Institute of Neuropharmacology and Department of 
      Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of 
      Medical Sciences, Kerman, Iran. k.khoramipour@kmu.ac.ir.
FAU - Chamari, Karim
AU  - Chamari K
AD  - Aspetar Qatar Orthopaedic and Sports Medicine Hospital, Doha, Qatar.
LA  - eng
PT  - Journal Article
DEP - 20230628
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - 0 (Amyloid beta-Peptides)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Leptin)
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
RN  - 0 (tau Proteins)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Amyloid beta-Peptides/metabolism
MH  - Amyloid Precursor Protein Secretases/metabolism
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
MH  - Leptin/metabolism/pharmacology
MH  - *High-Intensity Interval Training
MH  - Aspartic Acid Endopeptidases/metabolism/pharmacology
MH  - tau Proteins/metabolism
MH  - Hippocampus/metabolism
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Mammals/metabolism
OTO - NOTNLM
OT  - Cognitive function
OT  - HIIT
OT  - Leptin resistance
OT  - Obesity
EDAT- 2023/06/28 13:08
MHDA- 2023/09/05 06:42
CRDT- 2023/06/28 11:14
PHST- 2023/02/07 00:00 [received]
PHST- 2023/04/29 00:00 [accepted]
PHST- 2023/09/05 06:42 [medline]
PHST- 2023/06/28 13:08 [pubmed]
PHST- 2023/06/28 11:14 [entrez]
AID - 10.1007/s10571-023-01357-1 [pii]
AID - 10.1007/s10571-023-01357-1 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2023 Oct;43(7):3465-3478. doi: 10.1007/s10571-023-01357-1. 
      Epub 2023 Jun 28.