PMID- 37379720
OWN - NLM
STAT- MEDLINE
DCOM- 20230821
LR  - 20230824
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 178
DP  - 2023 Aug
TI  - Prenatal exposure to multiple persistent organic pollutants in association with 
      adiposity markers and blood pressure in preadolescents.
PG  - 108056
LID - S0160-4120(23)00329-X [pii]
LID - 10.1016/j.envint.2023.108056 [doi]
AB  - BACKGROUND: Several studies have reported that prenatal exposure to some 
      persistent organic pollutants (POPs) is associated with higher adiposity in 
      childhood. Few studies have assessed whether this finding persists into 
      adolescence, and few have considered exposure to POPs as a mixture. This study 
      aims to assess the association between prenatal exposure to multiple POPs and 
      adiposity markers and blood pressure in preadolescents. METHODS: This study 
      included 1667 mother-child pairs enrolled in the PELAGIE (France) and the INMA 
      (Spain) mother-child cohorts. Three polychlorobiphenyls (PCB 138, 153 and 180, 
      treated as a sum of PCBs) and three organochlorine pesticides 
      (p,p'-Dichlorodiphenyldichloroethylene [p,p'-DDE], beta-hexachlorocyclohexane 
      [beta-HCH], and hexachlorobenzene [HCB]) were assessed in maternal or cord serum. 
      Body mass index z-score (zBMI), abdominal obesity (waist-to-height ratio > 0.5), 
      percentage of fat mass, and blood pressure (mmHg) were measured at around 
      12 years of age. Single-exposure associations were studied using linear or 
      logistic regressions, and the POP mixture effect was evaluated using quantile 
      G-computation (qgComp) and Bayesian Kernel Machine Regression (BKMR). All models 
      were adjusted for potential confounders and performed for boys and girls together 
      and separately. RESULTS: Prenatal exposure to the POP mixture was associated with 
      higher zBMI (beta [95 % CI] of the qgComp = 0.15 [0.07; 0.24]) and percentage of 
      fat mass (0.83 [0.31; 1.35]), with no evidence of sex-specific association. These 
      mixture effects were also statistically significant using BKMR. These 
      associations were driven mainly by exposure to HCB and, to a lesser extent, to 
      beta-HCH. In addition, the single-exposure models showed an association between 
      beta-HCH and p,p'-DDE and higher systolic blood pressure, especially in girls 
      (p,p'-DDE for girls = 1.00 [0.15; 1.86]). No significant associations were found 
      for PCBs. CONCLUSION: This study suggests that prenatal exposure to POPs, 
      particularly organochlorine pesticides, remains associated with unfavorable 
      cardiometabolic health up to the age of 12.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Rouxel, Elke
AU  - Rouxel E
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Costet, Nathalie
AU  - Costet N
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Monfort, Christine
AU  - Monfort C
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Audouze, Karine
AU  - Audouze K
AD  - Universite Paris Cite, T3S, Inserm UMR S-1124, 75006 Paris, France.
FAU - Cirugeda, Lourdes
AU  - Cirugeda L
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid 28029, Spain; ISGlobal, 08003 Barcelona, 
      Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
FAU - Gaudreau, Eric
AU  - Gaudreau E
AD  - Centre de Toxicologie du Quebec (CTQ), Institut national de sante publique du 
      Quebec (INSPQ), Quebec, Canada.
FAU - Grimalt, Joan O
AU  - Grimalt JO
AD  - Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi 
      Girona 18, 08034 Barcelona, Catalonia, Spain.
FAU - Ibarluzea, Jesus
AU  - Ibarluzea J
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid 28029, Spain; Biodonostia Health Research 
      Institute, Group of Environmental Epidemiology and Child Development, Paseo 
      Doctor Begiristain S/n, 20014 Donostia-San Sebastian, Spain; Faculty of 
      Psychology, University of the Basque Country UPV/EHU, Avenida Tolosa 70, 20018 
      Donostia - San Sebastian, Spain.
FAU - Laine, Fabrice
AU  - Laine F
AD  - Univ Rennes, CHU Rennes, INSERM CIC1414, F-35000 Rennes, France.
FAU - Llop, Sabrina
AU  - Llop S
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid 28029, Spain; Epidemiology and 
      Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat 
      de Valencia, 46020 Valencia, Spain.
FAU - Lopez-Espinosa, Maria-Jose
AU  - Lopez-Espinosa MJ
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid 28029, Spain; Epidemiology and 
      Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat 
      de Valencia, 46020 Valencia, Spain; Faculty of Nursing and Chiropody, University 
      of Valencia, 46010 Valencia, Spain.
FAU - Rouget, Florence
AU  - Rouget F
AD  - Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, 
      environnement et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Santa-Marina, Loreto
AU  - Santa-Marina L
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid 28029, Spain; Biodonostia Health Research 
      Institute, Group of Environmental Epidemiology and Child Development, Paseo 
      Doctor Begiristain S/n, 20014 Donostia-San Sebastian, Spain; Ministry of Health 
      of the Basque Government, SubDirectorate for Public Health and Addictions of 
      Gipuzkoa, 20013 San Sebastian, Spain.
FAU - Vrijheid, Martine
AU  - Vrijheid M
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid 28029, Spain; ISGlobal, 08003 Barcelona, 
      Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
FAU - Chevrier, Cecile
AU  - Chevrier C
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Casas, Maribel
AU  - Casas M
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid 28029, Spain; ISGlobal, 08003 Barcelona, 
      Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
FAU - Warembourg, Charline
AU  - Warembourg C
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address: 
      charline.warembourg@inserm.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230622
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
RN  - 0 (Persistent Organic Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pesticides)
SB  - IM
MH  - Male
MH  - Pregnancy
MH  - Female
MH  - Adolescent
MH  - Humans
MH  - *Polychlorinated Biphenyls/toxicity
MH  - Persistent Organic Pollutants
MH  - Dichlorodiphenyl Dichloroethylene
MH  - Blood Pressure
MH  - Environmental Exposure/adverse effects/analysis
MH  - *Prenatal Exposure Delayed Effects
MH  - Hexachlorobenzene
MH  - Adiposity
MH  - Bayes Theorem
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - *Environmental Pollutants/adverse effects
MH  - Obesity
MH  - *Pesticides/toxicity
OTO - NOTNLM
OT  - Birth cohort
OT  - Blood pressure
OT  - Body mass index
OT  - Chemicals
OT  - Mixture
OT  - Persistent organic pollutant
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/06/29 01:08
MHDA- 2023/08/21 06:43
CRDT- 2023/06/28 18:05
PHST- 2023/03/09 00:00 [received]
PHST- 2023/06/13 00:00 [revised]
PHST- 2023/06/17 00:00 [accepted]
PHST- 2023/08/21 06:43 [medline]
PHST- 2023/06/29 01:08 [pubmed]
PHST- 2023/06/28 18:05 [entrez]
AID - S0160-4120(23)00329-X [pii]
AID - 10.1016/j.envint.2023.108056 [doi]
PST - ppublish
SO  - Environ Int. 2023 Aug;178:108056. doi: 10.1016/j.envint.2023.108056. Epub 2023 
      Jun 22.