PMID- 37379910 OWN - NLM STAT- MEDLINE DCOM- 20230911 LR - 20230911 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 895 DP - 2023 Oct 15 TI - Trimester-specific effects of maternal exposure to single and mixed metals on cord serum inflammatory cytokines levels: A prospective birth cohort study. PG - 165086 LID - S0048-9697(23)03709-9 [pii] LID - 10.1016/j.scitotenv.2023.165086 [doi] AB - BACKGROUND: Cord blood inflammatory cytokines are vital in early-life programming. An increasing number of studies concern the effect of maternal exposure to different metal elements during pregnancy on inflammatory cytokines, but limited studies have explored the association between maternal exposure to mixed metals and cord blood inflammatory cytokine levels. METHODS: We measured serum concentrations of vanadium (V), copper (Cu), arsenic (As), cadmium (Cd), and barium (Ba) in the first, second, and third trimesters and eight cord serum inflammatory cytokines (IFN-gamma, IL-1beta, IL-6, IL-8, IL-10, IL-12p70, IL-17A, and TNF-alpha) in 1436 mother-child dyads from the Ma'anshan Birth Cohort. Generalized linear models and Bayesian kernel machine regression (BKMR) were performed to assess the association of single and mixed metal exposure during each trimester with cord serum inflammatory cytokine levels, respectively. RESULTS: Regarding metal exposure in the first trimester, V was positively associated with TNF-alpha (beta = 0.33, 95 % CI: 0.13, 0.53); Cu was positively associated with IL-8 (beta = 0.23, 95 % CI: 0.07, 0.39); Ba was positively associated with IFN-gamma and IL-6; As was negatively associated with IFN-gamma and IL-17A; and Cd was negatively associated with IFN-gamma, IL-1beta, IL-12p70, IL-17A, and TNF-alpha. BKMR revealed that exposure to metal mixtures in the first trimester was positively associated with IL-8 and TNF-alpha but negatively associated with IL-17A. Moreover, V contributed the most to these associations. Interaction effects were observed between Cd and As and between Cd and Cu with IL-8, and between Cd and V with IL-17A. Among males, As decreased inflammatory cytokines; among females, Cu increased inflammatory cytokine levels, whereas Cd decreased inflammatory cytokine concentrations. CONCLUSIONS: Maternal exposure to metal mixtures in the first trimester interfered with cord serum inflammatory cytokine levels. The associations of maternal exposure to As, Cu and Cd with inflammatory cytokines showed sex differences. Further studies are warranted to support the findings and explore the mechanism of the susceptibility window and sex-specific disparity. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Wang, Xing AU - Wang X AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China. FAU - Tong, Juan AU - Tong J AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China. FAU - Liang, Chunmei AU - Liang C AD - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University; Hefei 230032, Anhui, China. FAU - Wang, Xueqing AU - Wang X AD - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University; Hefei 230032, Anhui, China. FAU - Ma, Yufan AU - Ma Y AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China. FAU - Tao, Shuman AU - Tao S AD - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University; Hefei 230032, Anhui, China. FAU - Liu, Meng AU - Liu M AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China. FAU - Wang, Yafei AU - Wang Y AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China. FAU - Liu, Jia AU - Liu J AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China. FAU - Yan, Shuangqin AU - Yan S AD - Ma'anshan Maternal and Child Health Care Hospital, Ma'anshan 243011, Anhui, China. FAU - Gao, Guopeng AU - Gao G AD - Ma'anshan Maternal and Child Health Care Hospital, Ma'anshan 243011, Anhui, China. FAU - Wu, Xiaoyan AU - Wu X AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University; Hefei 230032, Anhui, China. FAU - Huang, Kun AU - Huang K AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University; Hefei 230032, Anhui, China. FAU - Cao, Yunxia AU - Cao Y AD - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China. FAU - Tao, Fangbiao AU - Tao F AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University; Hefei 230032, Anhui, China. Electronic address: fbtao@ahmu.edu.cn. LA - eng PT - Journal Article DEP - 20230626 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Cytokines) RN - 0 (Interleukin-17) RN - 0 (Interleukin-6) RN - 00BH33GNGH (Cadmium) RN - 0 (Tumor Necrosis Factor-alpha) RN - 0 (Interleukin-8) RN - 00J9J9XKDE (Vanadium) SB - IM MH - Pregnancy MH - Humans MH - Female MH - Male MH - Cohort Studies MH - *Cytokines MH - *Maternal Exposure MH - Interleukin-17 MH - Prospective Studies MH - Interleukin-6 MH - Cadmium MH - Tumor Necrosis Factor-alpha MH - Bayes Theorem MH - Interleukin-8 MH - Vanadium OTO - NOTNLM OT - BKMR OT - Birth cohort OT - Inflammatory cytokines OT - Metal mixtures OT - Prenatal exposure COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/06/29 01:08 MHDA- 2023/09/11 06:43 CRDT- 2023/06/28 19:13 PHST- 2023/05/09 00:00 [received] PHST- 2023/06/14 00:00 [revised] PHST- 2023/06/21 00:00 [accepted] PHST- 2023/09/11 06:43 [medline] PHST- 2023/06/29 01:08 [pubmed] PHST- 2023/06/28 19:13 [entrez] AID - S0048-9697(23)03709-9 [pii] AID - 10.1016/j.scitotenv.2023.165086 [doi] PST - ppublish SO - Sci Total Environ. 2023 Oct 15;895:165086. doi: 10.1016/j.scitotenv.2023.165086. Epub 2023 Jun 26.