PMID- 37380006
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 179
DP  - 2023 Aug
TI  - Intrinsic capacity in acutely hospitalized older adults.
PG  - 112247
LID - S0531-5565(23)00168-7 [pii]
LID - 10.1016/j.exger.2023.112247 [doi]
AB  - OBJECTIVES: We aimed to examine the association between intrinsic capacity (IC) 
      and adverse outcomes of hospitalization. DESIGN: A prospective observational 
      cohort study. SETTING AND PARTICIPANTS: We recruited patients aged 65 years or 
      older who were admitted to the geriatric ward of an acute hospital between Oct 
      2019 and Sep 2022. MEASUREMENTS: Each of the five IC domains (locomotion, 
      cognition, vitality, sensory, and psychological capacity) was graded into three 
      levels, and the composite IC score was calculated (0, lowest; 10, highest). 
      Hospital-related outcomes were defined as in-hospital death, hospital-associated 
      complications (HACs), length of hospital stay, and frequency of discharge to 
      home. RESULTS: In total, 296 individuals (mean age 84.7 +/- 5.4 years, 42.7 % 
      males) were analyzed. Mean composite IC score was 6.5 +/- 1.8, and 95.6 % of 
      participants had impairment in at least one IC domain. A higher composite IC 
      score was independently associated with lower frequency of in-hospital death 
      (odds ratio [OR] 0.59) and HACs (OR 0.71), higher frequency of discharge to home 
      (OR 1.50), and shorter length of hospital stay (beta = -0.24, p < 0.01). The 
      locomotion, cognition, and psychological domains were independently associated 
      with the occurrence of HACs, discharge destination, and length of hospital stay. 
      CONCLUSION: Evaluating IC was feasible in the hospital setting and was associated 
      with outcomes of hospitalization. For older inpatients with decreased IC, 
      integrated management may be required to achieve functional independence.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Nagae, Masaaki
AU  - Nagae M
AD  - Department of Community Healthcare and Geriatrics, Nagoya University Graduate 
      School of Medicine, Aichi, Japan; Department of Emergency Room and General 
      Medicine, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan.
FAU - Umegaki, Hiroyuki
AU  - Umegaki H
AD  - Department of Community Healthcare and Geriatrics, Nagoya University Graduate 
      School of Medicine, Aichi, Japan. Electronic address: umegaki@med.nagoya-u.ac.jp.
FAU - Komiya, Hitoshi
AU  - Komiya H
AD  - Department of Community Healthcare and Geriatrics, Nagoya University Graduate 
      School of Medicine, Aichi, Japan.
FAU - Nakashima, Hirotaka
AU  - Nakashima H
AD  - Department of Community Healthcare and Geriatrics, Nagoya University Graduate 
      School of Medicine, Aichi, Japan.
FAU - Fujisawa, Chisato
AU  - Fujisawa C
AD  - Department of Community Healthcare and Geriatrics, Nagoya University Graduate 
      School of Medicine, Aichi, Japan.
FAU - Watanabe, Kazuhisa
AU  - Watanabe K
AD  - Department of Community Healthcare and Geriatrics, Nagoya University Graduate 
      School of Medicine, Aichi, Japan.
FAU - Yamada, Yosuke
AU  - Yamada Y
AD  - Department of Community Healthcare and Geriatrics, Nagoya University Graduate 
      School of Medicine, Aichi, Japan.
FAU - Miyahara, Shuzo
AU  - Miyahara S
AD  - Department of Community Healthcare and Geriatrics, Nagoya University Graduate 
      School of Medicine, Aichi, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20230627
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Male
MH  - Humans
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Prospective Studies
MH  - Hospital Mortality
MH  - *Hospitalization
MH  - Length of Stay
MH  - *Patient Discharge
OTO - NOTNLM
OT  - Hospital-associated complications
OT  - In-hospital death
OT  - Intrinsic capacity
OT  - Older patients
COIS- Declaration of competing interest All authors declare no conflicts of interest.
EDAT- 2023/06/29 01:08
MHDA- 2023/10/23 00:44
CRDT- 2023/06/28 19:13
PHST- 2023/04/24 00:00 [received]
PHST- 2023/06/24 00:00 [revised]
PHST- 2023/06/26 00:00 [accepted]
PHST- 2023/10/23 00:44 [medline]
PHST- 2023/06/29 01:08 [pubmed]
PHST- 2023/06/28 19:13 [entrez]
AID - S0531-5565(23)00168-7 [pii]
AID - 10.1016/j.exger.2023.112247 [doi]
PST - ppublish
SO  - Exp Gerontol. 2023 Aug;179:112247. doi: 10.1016/j.exger.2023.112247. Epub 2023 
      Jun 27.