PMID- 37380468
OWN - NLM
STAT- MEDLINE
DCOM- 20230630
LR  - 20230811
IS  - 1880-9952 (Electronic)
IS  - 1346-4280 (Print)
IS  - 1346-4280 (Linking)
VI  - 63
IP  - 2
DP  - 2023
TI  - High-grade B-cell lymphoma with 11q aberrations: A single-center study.
PG  - 121-131
LID - 10.3960/jslrt.23007 [doi]
AB  - High-grade B-cell lymphoma with 11q aberrations (HGBL-11q) has been classified 
      for the first time as a high-grade mature B-cell neoplasm according to the 5th 
      edition of the World Health Organization Classification of Tumors of 
      Hematopoietic and Lymphoid Tissues. HGBL-11q is morphologically and 
      immunohistochemically similar to Burkitt lymphoma (BL) or HGBL; it is 
      characterized by gain in the 11q23.2-11q23.3 region and loss in the 11q24.1-qter 
      region but it lacks MYC translocation. HGBL-11q is a rare tumor, and its exact 
      frequency in Japan remains unclear. In this study, we classified 113 Germinal 
      center B-cell (GCB) type aggressive B-cell lymphomas (BCLs), which were divided 
      into BL, high-grade (HG), and large cell (LC) morphologies. We performed 
      fluorescence in situ hybridization (FISH) to identify 11q aberrations. Nine 
      patients had 11q aberrations (7.96%, 9/113), including six HGBL-11q. The age 
      range was from 8 to 87 years, and all were male. Six out of 14 patients with HG 
      morphology were diagnosed with HGBL-11q (6/14, 42.9%). HGBL-11q has been found to 
      occur primarily in children and young adults but also in middle-aged and older 
      adults. Patients with HG morphology without MYC translocation should undergo FISH 
      for 11q aberrations regardless of age. However, the pathogenesis, clinical 
      findings, and prognosis of HGBL-11q remain unclear. The accumulation of cases 
      with an accurate HGBL-11q diagnosis in daily practice and accurate and detailed 
      data on HGBL-11q will contribute to further understanding of 11q aberrations.
FAU - Yamada, Shoki
AU  - Yamada S
AD  - Department of Diagnostic Pathology, Fukushima Medical University School of 
      Medicine, Fukushima, Japan.
FAU - Oka, Yuka
AU  - Oka Y
AD  - Department of Diagnostic Pathology, Fukushima Medical University School of 
      Medicine, Fukushima, Japan.
FAU - Muramatsu, Moe
AU  - Muramatsu M
AD  - Department of Diagnostic Pathology, Fukushima Medical University School of 
      Medicine, Fukushima, Japan.
FAU - Hashimoto, Yuko
AU  - Hashimoto Y
AD  - Department of Diagnostic Pathology, Fukushima Medical University School of 
      Medicine, Fukushima, Japan.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Clin Exp Hematop
JT  - Journal of clinical and experimental hematopathology : JCEH
JID - 101141257
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - In Situ Hybridization, Fluorescence
MH  - *Chromosome Aberrations
MH  - *Burkitt Lymphoma/diagnosis/genetics
MH  - Translocation, Genetic
MH  - Japan
PMC - PMC10410621
OTO - NOTNLM
OT  - 11q aberrations
OT  - fluorescence in situ hybridization
OT  - high-grade B-cell lymphoma
COIS- CONFLICT OF INTEREST The authors declare that they have no conflict of interest.
EDAT- 2023/06/29 01:08
MHDA- 2023/06/30 06:42
PMCR- 2023/06/28
CRDT- 2023/06/28 21:53
PHST- 2023/06/30 06:42 [medline]
PHST- 2023/06/29 01:08 [pubmed]
PHST- 2023/06/28 21:53 [entrez]
PHST- 2023/06/28 00:00 [pmc-release]
AID - 23007 [pii]
AID - 10.3960/jslrt.23007 [doi]
PST - ppublish
SO  - J Clin Exp Hematop. 2023;63(2):121-131. doi: 10.3960/jslrt.23007.