PMID- 37382072
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230913
IS  - 2532-179X (Electronic)
IS  - 1124-0490 (Print)
IS  - 1124-0490 (Linking)
VI  - 40
IP  - 2
DP  - 2023 Jun 29
TI  - Use of 6-minute walk test for assessing severity of interstitial lung disease: an 
      observational study.
PG  - e2023013
LID - 10.36141/svdld.v40i2.13991 [doi]
LID - e2023013
AB  - BACKGROUND: The 6-minute walk test (6MWT) is a potential tool for assessing the 
      severity of interstitial lung disease (ILD). OBJECTIVES: To explore the 
      relationship between 6MWT results and traditional measures including pulmonary 
      function and chest computed tomography(CT) and to determine factors that might 
      influence the 6-minute walk distance (6MWD). METHODS: Seventy-three patients with 
      ILD were enrolled at Peking University First Hospital. All patients underwent 
      6MWT, pulmonary CT, and pulmonary function tests and their correlations were 
      analyzed. Multivariate regression analysis was used to identify factors that 
      might impact 6MWD.  Results: Thirty (41.4%) of the patients were female and the 
      mean age was 66.1 +/- 9.6 years. 6MWD was correlated with forced expiratory volume 
      in 1 second (FEV1), forced vital capacity (FVC), total lung capacity (TLC), 
      diffusing capacity for carbon monoxide (DLCO) and DLCO%pred. The decrease in 
      oxygen saturation (SpO2) after the test was correlated with FEV1%pred, FVC%pred, 
      TLC, TLC%pred, DLCO, DLCO%pred and the percentage of normal lung calculated by 
      quantitative CT. The increase in Borg dyspnea scale was correlated with FEV1, 
      DLCO and the percentage of normal lung. The backward multivariate model (F = 
      15.257, P < 0.001, adjusted R2 = 0.498) indicated that 6MWD was predicted by age, 
      height, body weight, increase in heart rate, and DLCO. CONCLUSIONS: The 6MWT 
      results were closely correlated with pulmonary function and quantitative CT in 
      patients with ILD. However, in addition to disease severity, 6MWD was also 
      influenced by individual characteristics and the degree of patient effort, which 
      should thus be considered by clinicians when interpreting 6WMT results.
FAU - Hu, Zhan-Wei
AU  - Hu ZW
AD  - Department of Respiratory and Critical Care Medicine, Peking University First 
      Hospital, Beijing 100034. . hzhw88@163.com.
FAU - Gao, Li
AU  - Gao L
AD  - Department of Medical Imaging, Peking University First Hospital, Beijing 100034. 
      . 13910239293@163.com.
FAU - Yu, Qing
AU  - Yu Q
AD  - Department of Respiratory and Critical Care Medicine, Peking University First 
      Hospital, Beijing 100034. . yu_qing818@126.com.
FAU - Jin, Zhe
AU  - Jin Z
AD  - Department of Respiratory and Critical Care Medicine, Peking University First 
      Hospital, Beijing 100034. . 13671242220@139.com.
FAU - Liu, Ju-Hong
AU  - Liu JH
AD  - Department of General Medicine, Desheng Community Healthcare Center, Xicheng 
      District, Beijing 100120.. doctorliujh@sina.com.
FAU - Lian, Yuan-Yuan
AU  - Lian YY
AD  - Department of General Medicine, Shichahai Community Healthcare Center, Xicheng 
      District, Beijing 100034.. sshsqzx@sina.com.
FAU - Que, Cheng-Li
AU  - Que CL
AD  - Department of Respiratory and Critical Care Medicine, Peking University First 
      Hospital, Beijing 100034. . quechengli@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230629
PL  - Italy
TA  - Sarcoidosis Vasc Diffuse Lung Dis
JT  - Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
JID - 9610928
PMC - PMC10494753
COIS- None.
EDAT- 2023/06/29 06:42
MHDA- 2023/06/29 06:43
PMCR- 2023/01/01
CRDT- 2023/06/29 05:52
PHST- 2022/11/28 00:00 [received]
PHST- 2023/03/26 00:00 [accepted]
PHST- 2023/06/29 06:43 [medline]
PHST- 2023/06/29 06:42 [pubmed]
PHST- 2023/06/29 05:52 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - SVDLD-40-13 [pii]
AID - 10.36141/svdld.v40i2.13991 [doi]
PST - epublish
SO  - Sarcoidosis Vasc Diffuse Lung Dis. 2023 Jun 29;40(2):e2023013. doi: 
      10.36141/svdld.v40i2.13991.