PMID- 37382124
OWN - NLM
STAT- MEDLINE
DCOM- 20230630
LR  - 20231102
IS  - 1008-8830 (Print)
IS  - 2096-9228 (Electronic)
IS  - 1008-8830 (Linking)
VI  - 25
IP  - 6
DP  - 2023 Jun 15
TI  - [Clinical application of plasma exchange combined with continuous veno-venous 
      hemofiltration dialysis in children with refractory Kawasaki disease shock 
      syndrome].
PG  - 566-571
LID - 1008-8830(2023)06-0566-06 [pii]
LID - 10.7499/j.issn.1008-8830.2302116 [doi]
AB  - OBJECTIVES: To study the role of plasma exchange combined with continuous blood 
      purification in the treatment of refractory Kawasaki disease shock syndrome 
      (KDSS). METHODS: A total of 35 children with KDSS who were hospitalized in the 
      Department of Pediatric Intensive Care Unit, Hunan Children's Hospital, from 
      January 2019 to August 2022 were included as subjects. According to whether 
      plasma exchange combined with continuous veno-venous hemofiltration dialysis was 
      performed, they were divided into a purification group with 12 patients and a 
      conventional group with 23 patients. The two groups were compared in terms of 
      clinical data, laboratory markers, and prognosis. RESULTS: Compared with the 
      conventional group, the purification group had significantly shorter time to 
      recovery from shock and length of hospital stay in the pediatric intensive care 
      unit, as well as a significantly lower number of organs involved during the 
      course of the disease (P<0.05). After treatment, the purification group had 
      significant reductions in the levels of interleukin-6, tumor necrosis factor-alpha, 
      heparin-binding protein, and brain natriuretic peptide (P<0.05), while the 
      conventional group had significant increases in these indices after treatment 
      (P<0.05). After treatment, the children in the purification group tended to have 
      reductions in stroke volume variation, thoracic fluid content, and systemic 
      vascular resistance and an increase in cardiac output over the time of treatment. 
      CONCLUSIONS: Plasma exchange combined with continuous veno-venous hemofiltration 
      dialysis for the treatment of KDSS can alleviate inflammation, maintain fluid 
      balance inside and outside blood vessels, and shorten the course of disease, the 
      duration of shock and the length of hospital stay in the pediatric intensive care 
      unit.
FAU - Kang, Xia-Yan
AU  - Kang XY
AD  - Department of Pediatric Intensive Care Unit, Hunan Children's Hospital, Changsha 
      410007, China.
FAU - Yuan, Yuan-Hong
AU  - Yuan YH
FAU - Xu, Zhi-Yue
AU  - Xu ZY
FAU - Zhang, Xin-Ping
AU  - Zhang XP
AD  - Department of Pediatric Intensive Care Unit, Hunan Children's Hospital, Changsha 
      410007, China.
FAU - Fan, Jiang-Hua
AU  - Fan JH
FAU - Luo, Hai-Yan
AU  - Luo HY
FAU - Lu, Xiu-Lan
AU  - Lu XL
AD  - Department of Pediatric Intensive Care Unit, Hunan Children's Hospital, Changsha 
      410007, China.
FAU - Xiao, Zheng-Hui
AU  - Xiao ZH
AD  - Department of Pediatric Intensive Care Unit, Hunan Children's Hospital, Changsha 
      410007, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
TT  - 血浆置换联合连续性静脉-静脉血液滤过透析治疗在儿童川崎病休克综合征中的临床应用.
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
SB  - IM
MH  - Humans
MH  - Child
MH  - Plasma Exchange
MH  - *Mucocutaneous Lymph Node Syndrome/therapy
MH  - *Continuous Renal Replacement Therapy
MH  - Renal Dialysis
MH  - Plasmapheresis
MH  - *Shock
PMC - PMC10321425
OTO - NOTNLM
OT  - Child
OT  - Continuous veno-venous hemofiltration dialysis
OT  - Kawasaki disease shock syndrome
OT  - Plasma exchange
COIS- 所有作者均声明不存在利益冲突。
EDAT- 2023/06/29 13:42
MHDA- 2023/06/30 06:42
PMCR- 2023/06/15
CRDT- 2023/06/29 06:35
PHST- 2023/06/30 06:42 [medline]
PHST- 2023/06/29 13:42 [pubmed]
PHST- 2023/06/29 06:35 [entrez]
PHST- 2023/06/15 00:00 [pmc-release]
AID - 1008-8830(2023)06-0566-06 [pii]
AID - 10.7499/j.issn.1008-8830.2302116 [doi]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2023 Jun 15;25(6):566-571. doi: 
      10.7499/j.issn.1008-8830.2302116.