PMID- 37383590
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230702
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 14
IP  - 6
DP  - 2023 Jun 15
TI  - State of art on the mechanisms of laparoscopic sleeve gastrectomy in treating 
      type 2 diabetes mellitus.
PG  - 632-655
LID - 10.4239/wjd.v14.i6.632 [doi]
AB  - Obesity and type-2 diabetes mellitus (T2DM) are metabolic disorders. Obesity 
      increases the risk of T2DM, and as obesity is becoming increasingly common, more 
      individuals suffer from T2DM, which poses a considerable burden on health 
      systems. Traditionally, pharmaceutical therapy together with lifestyle changes is 
      used to treat obesity and T2DM to decrease the incidence of comorbidities and 
      all-cause mortality and to increase life expectancy. Bariatric surgery is 
      increasingly replacing other forms of treatment of morbid obesity, especially in 
      patients with refractory obesity, owing to its many benefits including good 
      long-term outcomes and almost no weight regain. The bariatric surgery options 
      have markedly changed recently, and laparoscopic sleeve gastrectomy (LSG) is 
      gradually gaining popularity. LSG has become an effective and safe treatment for 
      type-2 diabetes and morbid obesity, with a high cost-benefit ratio. Here, we 
      review the me-chanism associated with LSG treatment of T2DM, and we discuss 
      clinical studies and animal experiments with regard to gastrointestinal hormones, 
      gut microbiota, bile acids, and adipokines to clarify current treatment 
      modalities for patients with obesity and T2DM.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Liu, Fa-Shun
AU  - Liu FS
AD  - Department of General Surgery, Yangpu Hospital, Tongji University School of 
      Medicine, Shanghai 200090, China.
FAU - Wang, Song
AU  - Wang S
AD  - Department of General Surgery, Yangpu Hospital, Tongji University School of 
      Medicine, Shanghai 200090, China.
FAU - Guo, Xian-Shan
AU  - Guo XS
AD  - Department of Endocrinology, Xinxiang Central Hospital, Xinxiang 453000, Henan 
      Province, China.
FAU - Ye, Zhen-Xiong
AU  - Ye ZX
AD  - Department of General Surgery, Yangpu Hospital, Tongji University School of 
      Medicine, Shanghai 200090, China.
FAU - Zhang, Hong-Ya
AU  - Zhang HY
AD  - Central Laboratory, Yangpu District Control and Prevention Center, Shanghai 
      200090, China.
FAU - Li, Zhen
AU  - Li Z
AD  - Department of General Surgery, Yangpu Hospital, Tongji University School of 
      Medicine, Shanghai 200090, China. lizhen3829@126.com.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10294061
OTO - NOTNLM
OT  - Adipokines
OT  - Bile acids
OT  - Gastrointestinal hormones
OT  - Gut microbiota
OT  - Laparoscopic sleeve gastrectomy
OT  - Obesity
OT  - Type-2 diabetes mellitus
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2023/06/29 13:42
MHDA- 2023/06/29 13:43
PMCR- 2023/06/15
CRDT- 2023/06/29 11:53
PHST- 2022/12/17 00:00 [received]
PHST- 2023/04/01 00:00 [revised]
PHST- 2023/04/24 00:00 [accepted]
PHST- 2023/06/29 13:43 [medline]
PHST- 2023/06/29 13:42 [pubmed]
PHST- 2023/06/29 11:53 [entrez]
PHST- 2023/06/15 00:00 [pmc-release]
AID - 10.4239/wjd.v14.i6.632 [doi]
PST - ppublish
SO  - World J Diabetes. 2023 Jun 15;14(6):632-655. doi: 10.4239/wjd.v14.i6.632.