PMID- 37383593
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230702
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 14
IP  - 6
DP  - 2023 Jun 15
TI  - Application of urinary N-acetyl-beta-D-glucosaminidase combined with serum 
      retinol-binding protein in early detection of diabetic nephropathy.
PG  - 883-891
LID - 10.4239/wjd.v14.i6.883 [doi]
AB  - BACKGROUND: Diabetic nephropathy (DN) is a microangiopathy of type 2 diabetes 
      mellitus (T2DM), which can damage the kidney through various ways and mechanisms 
      due to the nature of the disease, involving the renal interstitium and glomeruli. 
      However, in the early stage of the disease, patients only showed kidney volume 
      increase and glomerular hyperthyroidism, and typical symptoms that are difficult 
      to arouse individual attention were noticed. AIM: To observe the expression of 
      serum retinol-binding protein (RBP) and urinary N-acetyl-beta-D-glucosaminidase 
      (NAG) in patients with DN, and to analyze their value in disease prediction, so 
      as to provide new targets for early diagnosis and treatment of DN. METHODS: The 
      baseline data of 50 T2DM patients treated in our hospital between January 2021 
      and December 2022 were retrospectively reviewed and included in group A. The 
      baseline data of 50 patients with type 2 DN admitted to our hospital during the 
      same period were collected and included in group B. The baseline data and serum 
      RBP and urine NAG expression were compared between the two groups to analyze 
      their value in the early prediction of DN. RESULTS: There was no significant 
      difference in age, gender, duration of diabetes, combined hyperlipidemia and 
      combined hypertension between the two groups (P > 0.05); the expression of 
      urinary NAG and serum RBP in group B was higher than that in group A, and the 
      difference was statistically significant (P < 0.05); a multiple logistic 
      regression model was established, and the results showed that urinary NAG and 
      serum RBP were related to the presence or absence of injury in diabetic patients, 
      and overexpression of urinary NAG and serum RBP may be risk factors for renal 
      injury in T2DM patients (OR > 1, P < 0.05); receiver operating curve curve was 
      plotted, and the results showed that the area under the curve of urinary NAG and 
      serum RBP expression alone and in combination for predicting DN was > 0.80, and 
      the predictive value was satisfactory; bivariate Spearman linear correlation 
      analysis showed that there was a positive correlation between urinary NAG and 
      serum RBP expression in patients with DN (r = 0.566, P = 0.000). CONCLUSION: The 
      increased expression of urinary NAG and serum RBP may be the risk factors leading 
      to the progression of T2DM to DN. The possibility of DN can be considered in 
      patients with urinary NAG and serum RBP overexpression by examining the 
      expression of urinary NAG and serum RBP in patients with T2DM in clinical 
      practice.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Lin, Zhi-Hao
AU  - Lin ZH
AD  - Department of Endocrinology, Wenzhou Hospital of Traditional Chinese Medicine 
      Affiliated to Zhejiang University of Traditional Chinese Medicine, Wenzhou 
      325000, Zhejiang Province, China.
FAU - Dai, Sheng-Feng
AU  - Dai SF
AD  - Department of Endocrinology, Wenzhou Hospital of Traditional Chinese Medicine 
      Affiliated to Zhejiang University of Traditional Chinese Medicine, Wenzhou 
      325000, Zhejiang Province, China.
FAU - Zhao, Jian-Nan
AU  - Zhao JN
AD  - Department of Endocrinology, Yongjia Hospital of Traditional Chinese Medicine, 
      Wenzhou 325000, Zhejiang Province, China.
FAU - Jiang, Yue
AU  - Jiang Y
AD  - Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, Zhejiang Province, China. jyygl9397@126.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10294068
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - Prediction
OT  - Serum retinol-binding protein
OT  - Type 2 diabetes mellitus
OT  - Urinary N-acetyl-beta-D-glucosaminidase
COIS- Conflict-of-interest statement: All authors have no conflict of interest.
EDAT- 2023/06/29 13:42
MHDA- 2023/06/29 13:43
PMCR- 2023/06/15
CRDT- 2023/06/29 11:53
PHST- 2023/03/14 00:00 [received]
PHST- 2023/04/16 00:00 [revised]
PHST- 2023/04/24 00:00 [accepted]
PHST- 2023/06/29 13:43 [medline]
PHST- 2023/06/29 13:42 [pubmed]
PHST- 2023/06/29 11:53 [entrez]
PHST- 2023/06/15 00:00 [pmc-release]
AID - 10.4239/wjd.v14.i6.883 [doi]
PST - ppublish
SO  - World J Diabetes. 2023 Jun 15;14(6):883-891. doi: 10.4239/wjd.v14.i6.883.