PMID- 37383594
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230702
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 14
IP  - 6
DP  - 2023 Jun 15
TI  - Comprehensive analysis of endoplasmic reticulum stress-related mechanisms in type 
      2 diabetes mellitus.
PG  - 820-845
LID - 10.4239/wjd.v14.i6.820 [doi]
AB  - BACKGROUND: The endoplasmic reticulum (ER) is closely related to a wide range of 
      cellular functions and is a key component to maintain and restore metabolic 
      health. Type 2 diabetes mellitus (T2DM) is a serious threat to human health, but 
      the ER stress (ERS)-related mechanisms in T2DM have not been fully elucidated. 
      AIM: To identify potential ERS-related mechanisms and crucial biomarkers in T2DM. 
      METHODS: We conducted gene set enrichment analysis (GSEA) and gene set variation 
      analysis (GSVA) in myoblast and myotube form GSE166502, and obtained the 
      differentially expressed genes (DEGs). After intersecting with ERS-related genes, 
      we obtained ERS-related DEGs. Finally, functional analyses, immune infiltration, 
      and several networks were established. RESULTS: Through GSEA and GSVA, we 
      identified several metabolic and immune-related pathways. We obtained 227 
      ERS-related DEGs and constructed several important networks that help to 
      understand the mechanisms and treatment of T2DM. Finally, memory CD4(+) T cells 
      accounted for the largest proportion of immune cells. CONCLUSION: This study 
      revealed ERS-related mechanisms in T2DM, which might contribute to new ideas and 
      insights into the mechanisms and treatment of T2DM.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Liang, Bo
AU  - Liang B
AD  - Department of Nephrology, The Key Laboratory for the Prevention and Treatment of 
      Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney 
      and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military 
      Medical University), Chongqing 400037, China.
FAU - Chen, Shu-Wen
AU  - Chen SW
AD  - Department of Endocrinology, Shanghai Baoshan Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai 200000, China.
FAU - Li, Yuan-Yuan
AU  - Li YY
AD  - Department of Endocrinology, Shanghai Baoshan Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai 200000, China.
FAU - Zhang, Shun-Xiao
AU  - Zhang SX
AD  - Department of Endocrinology, Shanghai Baoshan Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai 200000, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Endocrinology, Shanghai Baoshan Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai 200000, China. yan_2999bs@163.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10294059
OTO - NOTNLM
OT  - Biomarkers
OT  - Endoplasmic reticulum stress
OT  - Memory CD4+ T cells
OT  - Type 2 diabetes mellitus
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2023/06/29 13:42
MHDA- 2023/06/29 13:43
PMCR- 2023/06/15
CRDT- 2023/06/29 11:53
PHST- 2022/12/10 00:00 [received]
PHST- 2022/12/27 00:00 [revised]
PHST- 2023/04/04 00:00 [accepted]
PHST- 2023/06/29 13:43 [medline]
PHST- 2023/06/29 13:42 [pubmed]
PHST- 2023/06/29 11:53 [entrez]
PHST- 2023/06/15 00:00 [pmc-release]
AID - 10.4239/wjd.v14.i6.820 [doi]
PST - ppublish
SO  - World J Diabetes. 2023 Jun 15;14(6):820-845. doi: 10.4239/wjd.v14.i6.820.