PMID- 3738412
OWN - NLM
STAT- MEDLINE
DCOM- 19860925
LR  - 20041117
IS  - 0586-5581 (Print)
IS  - 0586-5581 (Linking)
IP  - Pt 1
DP  - 1986
TI  - Theory for calcium-phosphate crystal formation in tissue from scanning electron 
      microscope data.
PG  - 151-6
AB  - Scanning electron microscope (SEM) morphological analysis combined with energy 
      dispersive characteristic x-ray analysis provides insight into the mechanism of 
      biological mineralization. A time series of tissue micrographs and mineralization 
      measurements can permit the determination of the mineralization kinetic behavior 
      and is the basis upon which a computer model has been devised. The computer model 
      is constructed from fundamental principles of crystal nucleation and 
      precipitation theory. Various general forms of the model are tested against the 
      laboratory data for goodness-of-fit using the least squares method, and two 
      models are found to be acceptable. Both of the acceptable models involve 
      inhibition of the mineralization process which has a reaction order ranging from 
      one to two. A third model involving constant nucleation rate must be rejected. 
      Having established working first principle models for the mineralization process, 
      one can compute a constant number of nucleation sites and a supersaturation value 
      for calcium in various mineralized tissues such as the spongiosa and fibrosa of 
      heart valve leaflet implants. These quantities are determined and used in 
      discussing a general theory for biomineralization which emphasizes therapeutic 
      considerations.
FAU - Nelson, A C
AU  - Nelson AC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Scan Electron Microsc
JT  - Scanning electron microscopy
JID - 0371617
RN  - 0 (Calcium Phosphates)
SB  - IM
MH  - Animals
MH  - Calcinosis/*pathology
MH  - Calcium Phosphates/*metabolism
MH  - Crystallization
MH  - Heart Valves/transplantation/ultrastructure
MH  - Humans
MH  - Mathematics
MH  - Microscopy, Electron, Scanning/methods
MH  - Models, Biological
MH  - Swine
MH  - Transplantation, Heterologous
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
PST - ppublish
SO  - Scan Electron Microsc. 1986;(Pt 1):151-6.