PMID- 37385792
OWN - NLM
STAT- MEDLINE
DCOM- 20230703
LR  - 20230703
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 48
IP  - 6
DP  - 2023 Jun 25
TI  - [Observation of the long-term clinical efficacy of "Fuyang Guben" 
      acupuncture-moxibustion therapy on perennial allergic rhinitis and its effects on 
      the total IgE and IL-4 in the serum].
PG  - 600-5
LID - 10.13702/j.1000-0607.20221293 [doi]
AB  - OBJECTIVE: To investigate the long-term clinical efficacy and safety of "Fuyang 
      Guben" (supporting yang and consolidating root) acupuncture-moxibustion therapy 
      on perennial allergic rhinitis (PAR), and to explore its functioning mechanism. 
      METHODS: The patients with PAR were randomly divided into acupuncture + western 
      medicine group (n=30) and western medicine group (n=30). In the western medicine 
      group, fluticasone propionate nasal spray was administered, one spray in each 
      nostril in one treatment, once a day, for 6 weeks. On the basis of the western 
      medicine group, fuyangguben acupuncture-moxibustion therapy was supplemented. 
      Acupuncture was applied to Shangxing (GV23), Yintang (GV24+), and bilateral 
      Yingxiang (LI20), Shangyingxiang (EX-HN8), Sibai (ST2), Hegu (LI4) and Chize 
      (LU5); warm needling was applied at Dazhui (GV14). The patients of this group 
      received 30 min of acupuncture-moxibustion therapy 3 times weekly during the 
      first 4 weeks and twice a week in the last 2 weeks, totally for 6 weeks. Before 
      treatment, after treatment, in week 10, 18 and 30 of follow-up visits, the 
      reflective total nasal symptom score (rTNSS), the total non-nasal symptom score 
      (TNNSS), the total ophthalmic symptom score (TOSS), and the score of the rhinitis 
      quality of life (RQLQ) scale were compared in the patients of the two groups 
      separately. Using ELISA, the serum concentrations of total immunoglobulin E (IgE) 
      and interleukin-4 (IL-4) were detected before and after treatment. RESULTS: After 
      treatment, the rTNSS, TNNSS, TOSS, as well as RQLQ score were lower in comparison 
      with those before treatment in each group (P<0.05).The rTNSS, TNNSS, TOSS and the 
      score of RQLQ in the week 10, 18 and 30 of follow-up visits were reduced when 
      compared with those before treatment in each group (P<0.05), and these scores in 
      the acupuncture + western medicine group were remarkably lower than those of the 
      western medicine group (P<0.05). After treatment, the serum contents of total IgE 
      and IL-4 were significantly decreased when compared with those before treatment 
      in the acupuncture + western medicine group (P<0.05), and these indicators in the 
      acupuncture + western medicine group were lower than those of the western 
      medicine group (P<0.05). CONCLUSION: On the base of treatment with fluticasone 
      propionate nasal spray, "Fuyang Guben" acupuncture-moxibustion therapy is safe 
      and effective on PAR, presenting a remarkably long-term efficacy. The functioning 
      mechanism may be related to the down-regulation of total IgE and IL-4 in serum.
FAU - Wu, Fei-Hu
AU  - Wu FH
AD  - Department of Otolaryngology, The First Affiliated Hospital of Anhui University 
      of Chinese Medicine, Hefei 230031,China.
FAU - Zha, Bi-Xiang
AU  - Zha BX
AD  - Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Anhui 
      University of Chinese Medicine, Hefei 230031,China.
FAU - Zhang, Ting-Ting
AU  - Zhang TT
AD  - Department of Otolaryngology, The First Affiliated Hospital of Anhui University 
      of Chinese Medicine, Hefei 230031,China.
FAU - Chen, Zhuo-Hong
AU  - Chen ZH
AD  - Department of Otolaryngology, The First Affiliated Hospital of Anhui University 
      of Chinese Medicine, Hefei 230031,China.
FAU - Zhao, Hong
AU  - Zhao H
AD  - Acupuncture and Moxibustion Hospital, China Academy of Chinese Medical Sciences, 
      Beijing 100700.
FAU - Liu, Gang
AU  - Liu G
AD  - Department of Otolaryngology, The First Affiliated Hospital of Anhui University 
      of Chinese Medicine, Hefei 230031,China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
RN  - 207137-56-2 (Interleukin-4)
RN  - 0 (Nasal Sprays)
RN  - CUT2W21N7U (Fluticasone)
SB  - IM
MH  - Humans
MH  - *Moxibustion
MH  - Interleukin-4
MH  - Nasal Sprays
MH  - Quality of Life
MH  - *Acupuncture Therapy
MH  - Treatment Outcome
MH  - Fluticasone
MH  - *Rhinitis, Allergic/therapy
OTO - NOTNLM
OT  - Immunoglobulin E
OT  - Interleukin-4
OT  - Long-term efficacy
OT  - Perennial allergic rhinitis
OT  - "Fuyang Guben" acupuncture-moxibustion therapy
EDAT- 2023/06/30 01:06
MHDA- 2023/07/03 06:41
CRDT- 2023/06/29 21:37
PHST- 2023/07/03 06:41 [medline]
PHST- 2023/06/30 01:06 [pubmed]
PHST- 2023/06/29 21:37 [entrez]
AID - 10.13702/j.1000-0607.20221293 [doi]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2023 Jun 25;48(6):600-5. doi: 10.13702/j.1000-0607.20221293.