PMID- 37386744
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20230829
IS  - 2162-3279 (Electronic)
VI  - 13
IP  - 8
DP  - 2023 Aug
TI  - Surgical outcomes following encephaloduroarteriosynangiosis in moyamoya disease 
      associated with hyperhomocysteinemia.
PG  - e3093
LID - 10.1002/brb3.3093 [doi]
LID - e3093
AB  - INTRODUCTION: This study investigated the effect of indirect revascularization 
      surgery in adult patients with moyamoya disease (MMD) complicated with 
      hyperhomocysteinemia (HHcy), and the effect of HHcy on the progression of adult 
      MMD. METHODS: A retrospective case-control study was conducted in patients with 
      MMD, with or without HHcy (n = 123). Postoperative collateral angiogenesis was 
      evaluated using the Matsushima grading system and disease progression using the 
      Suzuki staging system. Cerebral blood flow was evaluated before and after surgery 
      using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) and 
      neurological function prognosis using the improved Rankin score (mRS). Univariate 
      and multivariate logistic regression analyses were performed to determine risk 
      factors for the clinical outcomes. RESULTS: There was no significant difference 
      in the Suzuki stage composition ratios between the HHcy group and the non-HHcy 
      group before and after surgery. Non-HHcy patients were more likely to grow new 
      collateral circulating vessels after encephaloduroarteriosynangiosis (EDAS). 
      Moreover, postoperative DSC-MRI indicated that the time to peak significantly 
      improved. CONCLUSIONS: HHcy level may be a specific predictor of adverse clinical 
      outcomes after EDAS in patients with MMD and a risk factor for poor collateral 
      circulation and poor prognosis. Patients with MMD complicated with HHcy need to 
      strictly control homocysteine levels before EDAS surgery.
CI  - (c) 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Gao, Gan
AU  - Gao G
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Hao, Fang-Bin
AU  - Hao FB
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Wang, Qian-Nan
AU  - Wang QN
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Wang, Xiao-Peng
AU  - Wang XP
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Liu, Si-Meng
AU  - Liu SM
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Wang, Min-Jie
AU  - Wang MJ
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Guo, Qing-Bao
AU  - Guo QB
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Li, Jing-Jie
AU  - Li JJ
AD  - Chinese PLA Medical School, Beijing, China.
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Bao, Xiang-Yang
AU  - Bao XY
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Han, Cong
AU  - Han C
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
FAU - Duan, Lian
AU  - Duan L
AUID- ORCID: 0000-0001-7210-056X
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT03613701
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230629
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
RN  - Moyamoya disease 1
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Moyamoya Disease/complications/diagnostic imaging/surgery
MH  - Retrospective Studies
MH  - Case-Control Studies
MH  - *Hyperhomocysteinemia/complications
MH  - Treatment Outcome
PMC - PMC10454250
OTO - NOTNLM
OT  - collateral circulation
OT  - encephaloduroarteriosynangiosis
OT  - hyperhomocysteinemia
OT  - moyamoya disease
COIS- The authors declare that there is no conflict of interest.
EDAT- 2023/06/30 06:42
MHDA- 2023/08/28 06:42
PMCR- 2023/06/29
CRDT- 2023/06/30 00:53
PHST- 2023/05/11 00:00 [revised]
PHST- 2023/04/06 00:00 [received]
PHST- 2023/05/11 00:00 [accepted]
PHST- 2023/08/28 06:42 [medline]
PHST- 2023/06/30 06:42 [pubmed]
PHST- 2023/06/30 00:53 [entrez]
PHST- 2023/06/29 00:00 [pmc-release]
AID - BRB33093 [pii]
AID - 10.1002/brb3.3093 [doi]
PST - ppublish
SO  - Brain Behav. 2023 Aug;13(8):e3093. doi: 10.1002/brb3.3093. Epub 2023 Jun 29.