PMID- 37386749
OWN - NLM
STAT- MEDLINE
DCOM- 20240417
LR  - 20240417
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 59
IP  - 8
DP  - 2024 Apr
TI  - N400 event-related brain potential index of semantic processing and two-year 
      clinical outcomes in persons at high risk for psychosis: A longitudinal study.
PG  - 1877-1888
LID - 10.1111/ejn.16074 [doi]
AB  - The N400 event-related brain potential (ERP) semantic priming effect reflects 
      greater activation of contextually related versus unrelated concepts in long-term 
      semantic memory. Deficits in this measure have been found in persons with 
      schizophrenia and those at clinical high risk (CHR) for this disorder. In CHR 
      patients, we previously found that these deficits predict poorer social 
      functional outcomes after 1 year. In the present study, we tested whether these 
      deficits predicted greater psychosis-spectrum symptom severity and functional 
      impairment over 2 years. We measured N400 semantic priming effects at baseline in 
      CHR patients (n = 47) who viewed prime words each followed by a related/unrelated 
      target word at stimulus-onset asynchronies (SOAs) of 300 or 750 ms. We measured 
      psychosis-spectrum symptoms using the Structured Interview for Prodromal Symptoms 
      and role and social functioning with the Global Functioning: Role and Social 
      scales, at baseline, 1 (n = 29) and 2 years (n = 25). There was a significant 
      interaction between the N400 semantic priming effect at the 300-ms SOA and time 
      on GF:Role scores, indicating that, contrary to expectations, smaller baseline 
      N400 semantic priming effects were associated with more improvement in role 
      functioning from baseline to Year 1, but baseline N400 priming effects did not 
      predict role functioning at Year 2. N400 priming effects were not significantly 
      associated with different trajectories in psychosis-spectrum symptoms or social 
      functioning. Thus, CHR patients' N400 semantic priming effects did not predict 
      clinical outcomes over 2 years, suggesting that this ERP measure may have greater 
      value as a state or short-term prognostic neurophysiological biomarker.
CI  - (c) 2023 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Lepock, Jennifer R
AU  - Lepock JR
AUID- ORCID: 0000-0002-0337-0299
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Sanches, Marcos
AU  - Sanches M
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Ahmed, Sarah
AU  - Ahmed S
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Gerritsen, Cory J
AU  - Gerritsen CJ
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Korostil, Michele
AU  - Korostil M
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 
      Hamilton, Ontario, Canada.
AD  - St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
FAU - Mizrahi, Romina
AU  - Mizrahi R
AD  - Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
FAU - Kiang, Michael
AU  - Kiang M
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
LA  - eng
GR  - Miner's Lamp Innovation Fund in the Prevention and Early Detection of Severe 
      Mental Illness/
GR  - Ontario Ministry of Health and Long-Term Care/
GR  - Ontario Mental Health Foundation/
GR  - University of Toronto Academic Scholar Award/
PT  - Journal Article
DEP - 20230629
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Evoked Potentials/physiology
MH  - Semantics
MH  - Electroencephalography
MH  - Longitudinal Studies
MH  - Reaction Time/physiology
MH  - *Psychotic Disorders
MH  - Brain
OTO - NOTNLM
OT  - N400
OT  - clinical high risk
OT  - event-related potentials
OT  - functioning
OT  - psychosis
OT  - schizophrenia
EDAT- 2023/06/30 06:42
MHDA- 2024/04/17 06:42
CRDT- 2023/06/30 01:02
PHST- 2023/05/24 00:00 [revised]
PHST- 2023/01/12 00:00 [received]
PHST- 2023/06/13 00:00 [accepted]
PHST- 2024/04/17 06:42 [medline]
PHST- 2023/06/30 06:42 [pubmed]
PHST- 2023/06/30 01:02 [entrez]
AID - 10.1111/ejn.16074 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2024 Apr;59(8):1877-1888. doi: 10.1111/ejn.16074. Epub 2023 Jun 
      29.