PMID- 37390630
OWN - NLM
STAT- MEDLINE
DCOM- 20230904
LR  - 20230907
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 158
DP  - 2023 Aug
TI  - The unique expression pattern of human leukocyte antigen in trophoblasts 
      potentially explains the key mechanism of maternal-fetal tolerance and successful 
      pregnancy.
PG  - 103980
LID - S0165-0378(23)00186-9 [pii]
LID - 10.1016/j.jri.2023.103980 [doi]
AB  - The success of pregnancy mainly depends on immune tolerance of the mother for the 
      semi-allogeneic fetus. The placenta carrying paternal antigens develops in the 
      maternal uterus without suffering immune attack, making the underlying mechanism 
      of maternal tolerance an enduring mystery. As we all know, human leukocyte 
      antigen (HLA) plays an important role in antigen processing and presentation, 
      thus inducing specific immune responses. Therefore, it is reasonable to speculate 
      that the absence of classical HLA class-I（HLA-I) and HLA class-II (HLA-II) 
      molecules in trophoblasts may account for the maternal-fetal tolerance. Here, we 
      review the HLA-involved interactions between trophoblast cells and decidual 
      immune cells, which contribute to the immunotolerance in the development of 
      normal pregnancy. We also compare the similarity between the maternal-fetal 
      interface and tumor-immune microenvironment because the important role of HLA 
      molecules in tumor immune invasion can provide some references to studies of 
      maternal-fetal immune tolerance. Besides, the abnormal HLA expression is likely 
      to be associated with unexplained miscarriage, making HLA molecules potential 
      therapeutic targets. The advances reported by these studies may exert profound 
      influences on other research areas, including tumor immunity, organ 
      transplantation and autoimmune disease in the future.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Peng, Lijin
AU  - Peng L
AD  - The Lab of Reproduction Immunology, Shanghai Key Laboratory of Female 
      Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, 
      Fudan University Shanghai Medical College, Shanghai, China.
FAU - Zhao, Weijie
AU  - Zhao W
AD  - The Lab of Reproduction Immunology, Shanghai Key Laboratory of Female 
      Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, 
      Fudan University Shanghai Medical College, Shanghai, China.
FAU - Yin, Tingxuan
AU  - Yin T
AD  - The Lab of Reproduction Immunology, Shanghai Key Laboratory of Female 
      Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, 
      Fudan University Shanghai Medical College, Shanghai, China.
FAU - Xu, Chunfang
AU  - Xu C
AD  - The Lab of Reproduction Immunology, Shanghai Key Laboratory of Female 
      Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, 
      Fudan University Shanghai Medical College, Shanghai, China.
FAU - Wang, Guangchuan
AU  - Wang G
AD  - Center for Excellence in Molecular Cell Science, Shanghai Institute of 
      Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese 
      Academy of Sciences, Shanghai 200031, China.
FAU - Du, Meirong
AU  - Du M
AD  - The Lab of Reproduction Immunology, Shanghai Key Laboratory of Female 
      Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, 
      Fudan University Shanghai Medical College, Shanghai, China. Electronic address: 
      mrdu@fudan.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230615
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Trophoblasts/metabolism
MH  - Histocompatibility Antigens Class I
MH  - HLA Antigens
MH  - Immune Tolerance
MH  - Histocompatibility Antigens Class II/metabolism
MH  - Antigen Presentation
MH  - *Neoplasms
MH  - Maternal-Fetal Exchange
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Decidual immune cells
OT  - Human leukocyte antigen
OT  - Mater-fetal tolerance
OT  - Maternal-fetal interface
OT  - Miscarriage
OT  - Trophoblast
COIS- Declaration of Competing Interest The authors declare no conflicts of interest in 
      the authorship or publication.
EDAT- 2023/07/01 11:41
MHDA- 2023/09/04 06:43
CRDT- 2023/06/30 18:04
PHST- 2023/02/09 00:00 [received]
PHST- 2023/05/15 00:00 [revised]
PHST- 2023/06/12 00:00 [accepted]
PHST- 2023/09/04 06:43 [medline]
PHST- 2023/07/01 11:41 [pubmed]
PHST- 2023/06/30 18:04 [entrez]
AID - S0165-0378(23)00186-9 [pii]
AID - 10.1016/j.jri.2023.103980 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2023 Aug;158:103980. doi: 10.1016/j.jri.2023.103980. Epub 2023 
      Jun 15.