PMID- 37390813
OWN - NLM
STAT- MEDLINE
DCOM- 20231120
LR  - 20231129
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 108
IP  - 12
DP  - 2023 Nov 17
TI  - Traits of Patients With Pituitary Tumors in Multiple Endocrine Neoplasia Type 1 
      and Comparing Different Mutation Status.
PG  - e1532-e1541
LID - 10.1210/clinem/dgad387 [doi]
AB  - CONTEXT: Recent studies suggest that the clinical characteristics and biological 
      behavior of pituitary tumors (PITs) in patients with multiple endocrine neoplasia 
      type 1 (MEN1) may not be as aggressive as previously reported. Increased imaging 
      of the pituitary as recommended by screening guidelines identifies more tumors, 
      potentially at an earlier stage. However, it is unknown if these tumors have 
      different clinical characteristics in different MEN1 mutations. OBJECTIVE: To 
      assess characteristics of patients with MEN1 with and without PITs, and compare 
      among different MEN1 mutations. METHODS: Data of patients with MEN1 in a tertiary 
      referral center from 2010 to 2023 were retrospectively analyzed. RESULTS: 
      Forty-two patients with MEN1 were included. Twenty-four patients had PITs, 3 of 
      which were invasive and managed with transsphenoidal surgery. One PIT enlarged 
      during follow-up. Patients with PITs had a higher median age at MEN1 diagnosis 
      than those without PITs. MEN1 mutations were identified in 57.1% of patients, 
      including 5 novel mutations. In patients with PITs, those with MEN1 mutations 
      (mutation+/PIT+ group) had more additional MEN1-associated tumors than those 
      without (mutation-/PIT+ group). The mutation+/PIT+ group had a higher incidence 
      of adrenal tumors and a lower median age at initial manifestation of MEN1 than 
      the mutation-/PIT+ group. The most common neuroendocrine neoplasm was 
      nonfunctional in the mutation+/PIT+ group and insulin-secreting in the 
      mutation-/PIT+ group. CONCLUSION: This is the first study comparing 
      characteristics of patients with MEN1 with and without PITs harboring different 
      mutations. Patients without MEN1 mutations tended to have less organ involvement 
      and it might be reasonable for them to receive less intensive follow-up.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Lin, Kuan-Yu
AU  - Lin KY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Yunlin Branch, Douliu City 640203, Taiwan.
FAU - Kuo, Yu-Ting
AU  - Kuo YT
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
FAU - Cheng, Mei-Fang
AU  - Cheng MF
AD  - Department of Nuclear Medicine, National Taiwan University Hospital, Taipei 
      100225, Taiwan.
AD  - Institute of Environmental and Occupational Health Sciences, National Taiwan 
      University, Taipei 100025, Taiwan.
FAU - Chen, Pei-Lung
AU  - Chen PL
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
AD  - Graduate Institute of Medical Genomics and Proteomics, National Taiwan University 
      College of Medicine, Taipei 100233, Taiwan.
AD  - Department of Medical Genetics, National Taiwan University Hospital, Taipei 
      100225, Taiwan.
FAU - Wang, Hsiu-Po
AU  - Wang HP
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
FAU - Cheng, Tsu-Yao
AU  - Cheng TY
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
AD  - Department of Laboratory Medicine, National Taiwan University Cancer Center, 
      Taipei 106037, Taiwan.
FAU - Chang, Chia-Hsuin
AU  - Chang CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
FAU - Kao, Hsiang-Fong
AU  - Kao HF
AD  - Department of Medical Oncology, National Taiwan University Cancer Center, Taipei 
      106037, Taiwan.
FAU - Yang, Shih-Hung
AU  - Yang SH
AD  - Division of Neurosurgery, Department of Surgery, National Taiwan University 
      Hospital, Taipei 100225, Taiwan.
FAU - Li, Hung-Yuan
AU  - Li HY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
FAU - Lin, Chia-Hung
AU  - Lin CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu 302058, Taiwan.
FAU - Chou, Yuh-Tsyr
AU  - Chou YT
AD  - Graduate Institute of Medical Genomics and Proteomics, National Taiwan University 
      College of Medicine, Taipei 100233, Taiwan.
FAU - Chung, An-Ko
AU  - Chung AK
AD  - Graduate Institute of Medical Genomics and Proteomics, National Taiwan University 
      College of Medicine, Taipei 100233, Taiwan.
FAU - Wu, Wan-Chen
AU  - Wu WC
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
FAU - Lu, Jin-Ying
AU  - Lu JY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
FAU - Wang, Chih-Yuan
AU  - Wang CY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
AD  - Department of Internal Medicine, National Taiwan University College of Medicine, 
      Taipei 100233, Taiwan.
FAU - Hsih, Wen-Hui
AU  - Hsih WH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Yunlin Branch, Douliu City 640203, Taiwan.
FAU - Wen, Chen-Yu
AU  - Wen CY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Yunlin Branch, Douliu City 640203, Taiwan.
FAU - Yang, Wei-Shiung
AU  - Yang WS
AD  - Department of Internal Medicine, National Taiwan University College of Medicine, 
      Taipei 100233, Taiwan.
AD  - Graduate Institute of Clinical Medicine, National Taiwan University College of 
      Medicine, Taipei 100233, Taiwan.
FAU - Shih, Shyang-Rong
AU  - Shih SR
AUID- ORCID: 0000-0001-7424-1358
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      National Taiwan University Hospital, Taipei 100225, Taiwan.
AD  - Department of Internal Medicine, National Taiwan University College of Medicine, 
      Taipei 100233, Taiwan.
AD  - Center of Anti-Aging and Health Consultation, National Taiwan University 
      Hospital, Taipei 100225, Taiwan.
LA  - eng
GR  - Liver Disease Prevention and Treatment Research Foundation, Taiwan/
GR  - National Taiwan University Hospital/
GR  - National Taiwan University/
GR  - Wong-Yuan Endocrine Fund in Taiwan/
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Humans
MH  - *Multiple Endocrine Neoplasia Type 1/pathology
MH  - *Pituitary Neoplasms/epidemiology/genetics/pathology
MH  - Retrospective Studies
MH  - Mutation
MH  - Pituitary Gland/pathology
OTO - NOTNLM
OT  - MEN1 gene
OT  - multiple endocrine neoplasia type 1
OT  - pituitary tumors
EDAT- 2023/07/01 11:41
MHDA- 2023/11/20 06:54
CRDT- 2023/06/30 18:13
PHST- 2023/04/06 00:00 [received]
PHST- 2023/11/20 06:54 [medline]
PHST- 2023/07/01 11:41 [pubmed]
PHST- 2023/06/30 18:13 [entrez]
AID - 7216398 [pii]
AID - 10.1210/clinem/dgad387 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2023 Nov 17;108(12):e1532-e1541. doi: 
      10.1210/clinem/dgad387.