PMID- 37391888 OWN - NLM STAT- MEDLINE DCOM- 20230803 LR - 20230804 IS - 1522-1601 (Electronic) IS - 0161-7567 (Linking) VI - 135 IP - 2 DP - 2023 Aug 1 TI - Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial. PG - 421-435 LID - 10.1152/japplphysiol.00078.2023 [doi] AB - A large proportion of patients suffer from a persistent reduction in cardiorespiratory fitness after recovery from COVID-19, of which the effects on the heart may potentially be reversed through the effect of high-intensity interval training (HIIT). In the present study, we hypothesized that HIIT would increase left ventricular mass (LVM) and improve functional status and health-related quality of life (HRQoL) in individuals previously hospitalized for COVID-19. In this investigator-blinded, randomized controlled trial, 12 wk of supervised HIIT (4 x 4 min, three times a week) was compared with standard care (control) in individuals recently discharged from hospital due to COVID-19. LVM was assessed by cardiac magnetic resonance imaging (cMRI, primary outcome), whereas the pulmonary diffusing capacity (D(LCOc), secondary outcome) was examined by the single-breath method. Functional status and HRQoL were assessed by Post-COVID-19 functional scale (PCFS) and King's brief interstitial lung disease (KBILD) questionnaire, respectively. A total of 28 participants were included (age 57 +/- 10, 9 females; HIIT: 58 +/- 11, 4 females; standard care: 57 +/- 9, 5 females), LVM increased in the HIIT vs. standard care group with a between-group difference of 6.8 [mean, 95%CI: 0.8; 12.8] g; P = 0.029. There were no between-group differences in D(LCOc) or any other lung function metric, which gradually resolved in both groups. Descriptively, PCFS suggested fewer functional limitations in the HIIT group. KBILD improved similarly in the two groups. HIIT is an efficacious exercise intervention for increasing LVM in individuals previously hospitalized for COVID-19.NEW & NOTEWORTHY In this randomized clinical trial on individuals previously hospitalized for COVID-19, a 12 wk supervised high-intensity interval training (HIIT) scheme was found to increase left ventricular mass, whereas pulmonary diffusing capacity was unaffected. The findings indicate that HIIT is an efficacious exercise intervention for targeting the heart after COVID-19. FAU - Rasmussen, Iben Elmerdahl AU - Rasmussen IE AUID- ORCID: 0000-0001-6349-0308 AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Lok, Mathilde AU - Lok M AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Durrer, Cody Garett AU - Durrer CG AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Foged, Frederik AU - Foged F AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Schelde, Vera Graungaard AU - Schelde VG AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Budde, Josephine Bjorn AU - Budde JB AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Rasmussen, Rasmus Syberg AU - Rasmussen RS AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Hovighoff, Emma Fredskild AU - Hovighoff EF AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Rasmussen, Villads AU - Rasmussen V AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Lyngbaek, Mark AU - Lyngbaek M AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Jonck, Simon AU - Jonck S AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Krogh-Madsen, Rikke AU - Krogh-Madsen R AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. AD - Department of Infectious Diseases, University Hospital Copenhagen, Hvidovre Hospital, Hvidovre, Denmark. FAU - Lindegaard, Birgitte AU - Lindegaard B AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. AD - Department of Pulmonary Medicine and Infectious Diseases, North Zealand Hospital, Hillerod, Denmark. FAU - Jorgensen, Peter Godsk AU - Jorgensen PG AD - Department of Cardiology, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Kober, Lars AU - Kober L AD - Department of Cardiology, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Vejlstrup, Niels AU - Vejlstrup N AD - Department of Cardiology, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Klarlund Pedersen, Bente AU - Klarlund Pedersen B AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Ried-Larsen, Mathias AU - Ried-Larsen M AUID- ORCID: 0000-0002-8388-5291 AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. AD - Research Unit for Exercise Epidemiology, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Lund, Morten Asp Vonsild AU - Lund MAV AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - Department of Cardiology, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. FAU - Christensen, Regitse Hojgaard AU - Christensen RH AUID- ORCID: 0000-0001-5316-5341 AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. AD - Department of Cardiology, University Hospital Copenhagen, Herlev Hospital, Herlev, Denmark. FAU - Berg, Ronan M G AU - Berg RMG AUID- ORCID: 0000-0002-5757-9506 AD - Centre for Physical Activity Research, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. AD - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark. AD - Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, United Kingdom. LA - eng GR - MFE-176582/CIHR/Canada PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20230630 PL - United States TA - J Appl Physiol (1985) JT - Journal of applied physiology (Bethesda, Md. : 1985) JID - 8502536 SB - IM MH - Female MH - Humans MH - Quality of Life MH - *High-Intensity Interval Training MH - *COVID-19 MH - Heart MH - *Cardiorespiratory Fitness OTO - NOTNLM OT - cardiac magnetic resonance imaging OT - diffusing capacity OT - exercise capacity OT - left ventricular mass OT - long-COVID EDAT- 2023/07/01 11:42 MHDA- 2023/08/03 06:43 CRDT- 2023/07/01 00:43 PHST- 2023/08/03 06:43 [medline] PHST- 2023/07/01 11:42 [pubmed] PHST- 2023/07/01 00:43 [entrez] AID - 10.1152/japplphysiol.00078.2023 [doi] PST - ppublish SO - J Appl Physiol (1985). 2023 Aug 1;135(2):421-435. doi: 10.1152/japplphysiol.00078.2023. Epub 2023 Jun 30.