PMID- 37392373
OWN - NLM
STAT- MEDLINE
DCOM- 20230707
LR  - 20240202
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 37
IP  - 8
DP  - 2023 Aug
TI  - CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction 
      via decreasing inflammatory macrophage proportion and macrophage glycolysis in 
      STZ-induced diabetic mice.
PG  - e23047
LID - 10.1096/fj.202300424RR [doi]
AB  - Diabetic cardiomyopathy (DCM) is one of the main complications in type I diabetic 
      patients. Activated macrophage is critical for directing the process of 
      inflammation during the development of DCM. The present study focused on the 
      roles of CD226 on macrophage function during the DCM progression. It has been 
      found that the number of cardiac macrophages in the hearts of streptozocin 
      (STZ)-induced diabetes mice was significantly increased compared with that in 
      non-diabetes mice, and the expression level of CD226 on cardiac macrophages in 
      STZ-induced diabetes mice was higher than that in non-diabetes mice. CD226 
      deficiency attenuated the diabetes-induced cardiac dysfunction and decreased the 
      proportion of CD86(+) F4/80(+) macrophages in the diabetic hearts. Notably, 
      adoptive transfer of Cd226(-/-) - bone marrow derived macrophages (BMDMs) 
      alleviated diabetes-induced cardiac dysfunction, which may be due to the 
      attenuated migration capacity of Cd226(-/-) -BMDM under high glucose stimulation. 
      Furthermore, CD226 deficiency decreased the macrophage glycolysis accompanying by 
      the downregulated hexokinase 2 (HK2) and lactate dehydrogenase A (LDH-A) 
      expression. Taken together, these findings revealed the pathogenic roles of CD226 
      played in the process of DCM and provided a basis for the treatment of DCM.
CI  - (c) 2023 Federation of American Societies for Experimental Biology.
FAU - Hou, Yongli
AU  - Hou Y
AUID- ORCID: 0000-0002-3523-0418
AD  - Department of Immunology, Fourth Military Medical University, Xi'an, China.
FAU - Wang, Yazhen
AU  - Wang Y
AUID- ORCID: 0009-0006-9645-4446
AD  - Department of Immunology, Fourth Military Medical University, Xi'an, China.
FAU - Tang, Kang
AU  - Tang K
AUID- ORCID: 0000-0002-6756-0219
AD  - Department of Immunology, Fourth Military Medical University, Xi'an, China.
FAU - Yang, Yan
AU  - Yang Y
AUID- ORCID: 0000-0003-2489-1269
AD  - Department of Immunology, Fourth Military Medical University, Xi'an, China.
FAU - Wang, Yiwei
AU  - Wang Y
AUID- ORCID: 0009-0005-9778-700X
AD  - Department of Immunology, Fourth Military Medical University, Xi'an, China.
FAU - Liu, Ruiyan
AU  - Liu R
AUID- ORCID: 0000-0003-4658-6820
AD  - Department of Immunology, Fourth Military Medical University, Xi'an, China.
FAU - Wu, Bin
AU  - Wu B
AUID- ORCID: 0000-0001-7707-3273
AD  - Department of Pulmonary and Critical Care Medicine, Xijing Hospital, Fourth 
      Military Medical University, Xi'an, China.
FAU - Chen, Xutao
AU  - Chen X
AUID- ORCID: 0000-0003-4930-6468
AD  - Department of Immunology, Fourth Military Medical University, Xi'an, China.
AD  - Department of Implant Dentistry, School of Stomatology, Fourth Military Medical 
      University, Xi'an, China.
FAU - Fu, Zhaoyue
AU  - Fu Z
AUID- ORCID: 0000-0001-6918-3894
AD  - Department of Immunology, Fourth Military Medical University, Xi'an, China.
FAU - Zhao, Feng
AU  - Zhao F
AUID- ORCID: 0000-0002-6612-1150
AD  - Department of Pulmonary and Critical Care Medicine, Xijing Hospital, Fourth 
      Military Medical University, Xi'an, China.
FAU - Chen, Lihua
AU  - Chen L
AUID- ORCID: 0000-0003-2195-7330
AD  - Department of Immunology, Fourth Military Medical University, Xi'an, China.
LA  - eng
GR  - 82071848/MOST | National Natural Science Foundation of China (NSFC)/
GR  - 81901600/MOST | National Natural Science Foundation of China (NSFC)/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (CD226 antigen)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Diabetes Mellitus, Experimental/complications
MH  - *Diabetic Cardiomyopathies
MH  - Glycolysis
MH  - Heart
MH  - Macrophages
MH  - *Antigens, Differentiation, T-Lymphocyte/genetics
OTO - NOTNLM
OT  - CD226
OT  - diabetic cardiomyopathy
OT  - glycolysis
OT  - immune metabolism
OT  - macrophage
EDAT- 2023/07/01 21:07
MHDA- 2023/07/03 06:41
CRDT- 2023/07/01 11:43
PHST- 2023/06/01 00:00 [revised]
PHST- 2023/03/06 00:00 [received]
PHST- 2023/06/07 00:00 [accepted]
PHST- 2023/07/03 06:41 [medline]
PHST- 2023/07/01 21:07 [pubmed]
PHST- 2023/07/01 11:43 [entrez]
AID - 10.1096/fj.202300424RR [doi]
PST - ppublish
SO  - FASEB J. 2023 Aug;37(8):e23047. doi: 10.1096/fj.202300424RR.