PMID- 37393194
OWN - NLM
STAT- MEDLINE
DCOM- 20231009
LR  - 20231010
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 99
IP  - 5
DP  - 2023 Nov
TI  - Clinical profile and treatment outcomes among patients with sporadic and multiple 
      endocrine neoplasia syndrome-related primary hyperparathyroidism.
PG  - 449-458
LID - 10.1111/cen.14945 [doi]
AB  - OBJECTIVE: Accurate demarcation between multiple endocrine neoplasia, type 1 
      (MEN1)- related primary hyperparathyroidism (MPHPT) and sporadic PHPT (SPHPT) is 
      important to plan the management of primary parathyroid disease and surveillance 
      for other endocrine and nonendocrine tumours. The objective of this study is to 
      compare the clinical, biochemical and radiological features and surgical outcomes 
      in patients with MPHPT versus SPHPT and to identify the predictors of MEN1 
      syndrome in PHPT. DESIGN, PATIENTS AND MEASUREMENTS: This was an ambispective 
      observationalstudy involving 251 patients with SPHPT and 23 patients with MPHPT 
      evaluated at the endocrine clinic of All India Institute of Medical Sciences, New 
      Delhi, India between January 2015 and December 2021. RESULTS: The prevalence of 
      MEN1 syndrome among patients with PHPT was 8.2% and a genetic mutation was 
      identified by Sanger sequencing in 26.1% of patients with MPHPT. Patients with 
      MPHPT were younger (p < .001), had lower mean serum calcium (p = .01) and 
      alkaline phosphatase (ALP; p = .03) levels and lower bone mineral density (BMD) Z 
      score at lumbar spine (p < .001) and femoral neck (p = .007). The prevalence of 
      renal stones (p = .03) and their complications (p = .006) was significantly 
      higher in MPHPT group. On multivariable analysis, factors predictive of MPHPT 
      were hyperplasia on histopathology [OR 40.1, p < .001], ALP levels within 
      reference range [OR 5.6, p = .02] and lumbar spine BMD [OR 0.39 per unit increase 
      in Z score, p < .001]. CONCLUSIONS: Patients with MPHPT have more severe, 
      frequent and early onset of bone and renal involvement despite milder biochemical 
      features. A normal serum ALP, low BMD for age and gender at lumbar spine and 
      histopathology evidence of hyperplasia are predictive factors for MEN1 syndrome 
      in PHPT.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Mathew, Uthara E
AU  - Mathew UE
AD  - Department of Endocrinology and Metabolism, All India Institute of Medical 
      Sciences, New Delhi, India.
FAU - Goyal, Alpesh
AU  - Goyal A
AUID- ORCID: 0000-0003-0922-5022
AD  - Department of Endocrinology and Metabolism, All India Institute of Medical 
      Sciences, New Delhi, India.
FAU - Upadhyay, Ashish D
AU  - Upadhyay AD
AD  - Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Kandasamy, Devasenathipathy
AU  - Kandasamy D
AD  - Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Agarwal, Shipra
AU  - Agarwal S
AD  - Department of Pathology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Sharma, Chitresh K
AU  - Sharma CK
AD  - Department of Surgical Oncology, All India Institute of Medical Sciences, 
      Bilaspur, Himachal Pradesh, India.
FAU - Sharma, Arundhati
AU  - Sharma A
AD  - Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
FAU - Bal, Chandrasekhar
AU  - Bal C
AUID- ORCID: 0000-0003-4378-5584
AD  - Department of Nuclear Medicine, All India Institute of Medical Sciences, New 
      Delhi, India.
FAU - Tandon, Nikhil
AU  - Tandon N
AD  - Department of Endocrinology and Metabolism, All India Institute of Medical 
      Sciences, New Delhi, India.
FAU - Jyotsna, Viveka P
AU  - Jyotsna VP
AUID- ORCID: 0000-0002-9328-4502
AD  - Department of Endocrinology and Metabolism, All India Institute of Medical 
      Sciences, New Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20230701
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
SB  - IM
MH  - Humans
MH  - *Hyperparathyroidism, Primary/complications/surgery
MH  - Hyperplasia/complications
MH  - *Multiple Endocrine Neoplasia Type 1/complications/pathology
MH  - *Multiple Endocrine Neoplasia/complications
MH  - Treatment Outcome
MH  - Bone Density
OTO - NOTNLM
OT  - MEN1 syndrome
OT  - PHPT
OT  - bone mineral density
OT  - primary hyperparathyroidism
OT  - sporadic PHPT
EDAT- 2023/07/02 01:10
MHDA- 2023/10/09 06:42
CRDT- 2023/07/01 22:52
PHST- 2023/06/15 00:00 [revised]
PHST- 2023/04/25 00:00 [received]
PHST- 2023/06/20 00:00 [accepted]
PHST- 2023/10/09 06:42 [medline]
PHST- 2023/07/02 01:10 [pubmed]
PHST- 2023/07/01 22:52 [entrez]
AID - 10.1111/cen.14945 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2023 Nov;99(5):449-458. doi: 10.1111/cen.14945. Epub 2023 
      Jul 1.