PMID- 37393287 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230704 IS - 1758-5996 (Print) IS - 1758-5996 (Electronic) IS - 1758-5996 (Linking) VI - 15 IP - 1 DP - 2023 Jul 1 TI - Integrated biomarker profiling of the metabolome associated with type 2 diabetes mellitus among Tibetan in China. PG - 146 LID - 10.1186/s13098-023-01124-8 [doi] LID - 146 AB - INTRODUCTION: Metabolomic signatures of type 2 diabetes mellitus (T2DM) in Tibetan Chinese population, a group with high diabetes burden, remain largely unclear. Identifying the serum metabolite profile of Tibetan T2DM (T-T2DM) individuals may provide novel insights into early T2DM diagnosis and intervention. METHODS: Hence, we conducted untargeted metabolomics analysis of plasma samples from a retrospective cohort study with 100 healthy controls and 100 T-T2DM patients by using liquid chromatography-mass spectrometry. RESULTS: The T-T2DM group had significant metabolic alterations that are distinct from known diabetes risk indicators, such as body mass index, fasting plasma glucose, and glycosylated hemoglobin levels. The optimal metabolite panels for predicting T-T2DM were selected using a tenfold cross-validation random forest classification model. Compared with the clinical features, the metabolite prediction model provided a better predictive value. We also analyzed the correlation of metabolites with clinical indices and found 10 metabolites that were independently predictive of T-T2DM. CONCLUSION: By using the metabolites identified in this study, we may provide stable and accurate biomarkers for early T-T2DM warning and diagnosis. Our study also provides a rich and open-access data resource for optimizing T-T2DM management. CI - (c) 2023. The Author(s). FAU - Meng, Jinli AU - Meng J AD - Department of Radiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - Huang, Fangfang AU - Huang F AD - Hubei University of Chinese Medicine, Wuhan, 430065, China. FAU - Shi, Jing AU - Shi J AD - Department of Science and Education Section, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - Zhang, Chenghui AU - Zhang C AD - Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - Feng, Li AU - Feng L AD - Department of Radiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - Wang, Suyuan AU - Wang S AD - Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - Li, Hengyan AU - Li H AD - Department of Radiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - Guo, Yongyue AU - Guo Y AD - Department of Radiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - Hu, Xin AU - Hu X AD - Department of Radiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - Li, Xiaomei AU - Li X AD - Department of Radiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - He, Wanlin AU - He W AD - Department of Radiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. FAU - Cheng, Jian AU - Cheng J AD - Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China. cjbs2012@163.com. FAU - Wu, Yunhong AU - Wu Y AD - Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, Sichuan, China. wu_yunhong@163.com. LA - eng GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - XZ202102YD0026D/Science and Technology Plan Projects of Tibet Autonomous Region/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - 2021YJ0161/Sichuan Province Science and Technology Support Program/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - Q20042/Medical Research project of Sichuan Province/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - XZ202102YD0032C/the central government guides local projects/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ GR - 2021-YJ-2/Hospital level key project of Hospital of Chengdu office of People's Government of Tibetan Autonomous Region/ PT - Journal Article DEP - 20230701 PL - England TA - Diabetol Metab Syndr JT - Diabetology & metabolic syndrome JID - 101488958 PMC - PMC10314538 OTO - NOTNLM OT - Biomarker OT - Machine learning OT - Serum metabolomics OT - Tibetan OT - Type 2 diabetes mellitus COIS- The authors declare no competing interests. EDAT- 2023/07/02 01:10 MHDA- 2023/07/02 01:11 PMCR- 2023/07/01 CRDT- 2023/07/01 23:19 PHST- 2023/05/09 00:00 [received] PHST- 2023/06/25 00:00 [accepted] PHST- 2023/07/02 01:11 [medline] PHST- 2023/07/02 01:10 [pubmed] PHST- 2023/07/01 23:19 [entrez] PHST- 2023/07/01 00:00 [pmc-release] AID - 10.1186/s13098-023-01124-8 [pii] AID - 1124 [pii] AID - 10.1186/s13098-023-01124-8 [doi] PST - epublish SO - Diabetol Metab Syndr. 2023 Jul 1;15(1):146. doi: 10.1186/s13098-023-01124-8.