PMID- 37394097
OWN - NLM
STAT- MEDLINE
DCOM- 20230725
LR  - 20230725
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 328
DP  - 2023 Sep 1
TI  - Association between insulin and Nrf2 signalling pathway in Alzheimer's disease: A 
      molecular landscape.
PG  - 121899
LID - S0024-3205(23)00534-9 [pii]
LID - 10.1016/j.lfs.2023.121899 [doi]
AB  - Insulin, a well-known hormone, has been implicated as a regulator of blood 
      glucose levels for almost a century now. Over the past few decades, the 
      non-glycemic actions of insulin i.e. neuronal growth and proliferation have been 
      extensively studied. In 2005, Dr. Suzanne de La Monte and her team reported that 
      insulin might be involved in the pathogenesis of Alzheimer's Disease (AD) and 
      thus coined a term "Type-3 diabetes" This hypothesis was supported by several 
      subsequent studies. The nuclear factor erythroid 2- related factor 2 (Nrf2) 
      triggers a cascade of events under the regulation of distinct mechanisms 
      including protein stability, phosphorylation and nuclear cytoplasmic shuttling, 
      finally leading to the protection against oxidative damage. The Nrf2 pathway has 
      been investigated extensively in relevance to neurodegenerative disorders, 
      particularly AD. Many studies have indicated a strong correlation between insulin 
      and Nrf2 signalling pathways both in the periphery and the brainbut merely few of 
      them have focused on elucidating their inter-connective role in AD. The present 
      review emphasizes key molecular pathways that correlate the role of insulin with 
      Nrf2 during AD. The review has also identified key unexplored areas that could be 
      investigated in future to further establish the insulin and Nrf2 influence in AD.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Rahman, Syed Obaidur
AU  - Rahman SO
AD  - Pharmaceutical Medicine, Department of Pharmacology, School of Pharmaceutical 
      Education and Research, Jamia Hamdard, New Delhi 110062, India.
FAU - Khan, Tahira
AU  - Khan T
AD  - Department of Pharmacology, School of Pharmaceutical Education and Research, 
      Jamia Hamdard, New Delhi 110062, India.
FAU - Iqubal, Ashif
AU  - Iqubal A
AD  - Department of Pharmacology, School of Pharmaceutical Education and Research, 
      Jamia Hamdard, New Delhi 110062, India.
FAU - Agarwal, Shivani
AU  - Agarwal S
AD  - Department of Pharmacology, School of Pharmaceutical Education and Research, 
      Jamia Hamdard, New Delhi 110062, India.
FAU - Akhtar, Mohd
AU  - Akhtar M
AD  - Department of Pharmacology, School of Pharmaceutical Education and Research, 
      Jamia Hamdard, New Delhi 110062, India.
FAU - Parvez, Suhel
AU  - Parvez S
AD  - Neurobehavioral Pharmacology Laboratory, Department of Medical Elementology and 
      Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 
      110062, India.
FAU - Shah, Zahoor Ahmad
AU  - Shah ZA
AD  - Department of Medicinal and Biological Chemistry, University of Toledo, 3000 
      Arlington Avenue, Toledo, OH 43614, USA.
FAU - Najmi, Abul Kalam
AU  - Najmi AK
AD  - Department of Pharmacology, School of Pharmaceutical Education and Research, 
      Jamia Hamdard, New Delhi 110062, India. Electronic address: 
      aknajmi@jamiahamdard.ac.in.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230630
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Insulin)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
SB  - IM
MH  - Humans
MH  - *Alzheimer Disease/metabolism
MH  - Insulin/metabolism
MH  - NF-E2-Related Factor 2/genetics/metabolism
MH  - Oxidative Stress
MH  - Signal Transduction/physiology
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Heme oxygenase-1
OT  - Insulin signalling
OT  - Nuclear factor erythroid 2-related factor 2
OT  - PI3K-AKT pathway
COIS- Declaration of competing interest Authors declare no potential conflict of 
      interest.
EDAT- 2023/07/03 00:41
MHDA- 2023/07/24 06:42
CRDT- 2023/07/02 19:26
PHST- 2023/04/28 00:00 [received]
PHST- 2023/06/17 00:00 [revised]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/07/24 06:42 [medline]
PHST- 2023/07/03 00:41 [pubmed]
PHST- 2023/07/02 19:26 [entrez]
AID - S0024-3205(23)00534-9 [pii]
AID - 10.1016/j.lfs.2023.121899 [doi]
PST - ppublish
SO  - Life Sci. 2023 Sep 1;328:121899. doi: 10.1016/j.lfs.2023.121899. Epub 2023 Jun 
      30.