PMID- 37394194
OWN - NLM
STAT- MEDLINE
DCOM- 20230724
LR  - 20230724
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 337
DP  - 2023 Oct
TI  - Associations between urinary phthalate metabolite concentrations and rheumatoid 
      arthritis in the U.S. adult population.
PG  - 139382
LID - S0045-6535(23)01649-1 [pii]
LID - 10.1016/j.chemosphere.2023.139382 [doi]
AB  - Phthalates are ubiquitous environmental contaminants. Nevertheless, limited data 
      is available about the impacts of phthalates on rheumatoid arthritis (RA). The 
      purpose of this study was to use National Health and Nutrition Examination Survey 
      (NHANES) data from 2005 to 2018 to assess the individual and combined effects of 
      exposure to phthalate mixtures on RA in adults. A total of 8240 participants with 
      complete data participated in the study, of whom 645 had RA. The levels of ten 
      phthalate metabolites were detected in urine samples. In the single-pollutant 
      models, independent associations were identified between urinary 
      mono-(carboxyoctyl) phthalate (MCOP), mono-(3-carboxylpropyl) phthalate (MCPP), 
      mono-isobutyl phthalate (MiBP) and mono-benzyl phthalate (MBzP) with the 
      incidence of RA. The results of multi-pollutant models, including weighted 
      quantile sum (WQS) regression, quantile-based g computation (qgcomp), and 
      Bayesian kernel machine regression (BKMR) approaches consistently revealed that 
      co-exposure to phthalates was positively associated with RA incidence. Such 
      association was more pronounced in adults over 60 years of age, where MCOP was 
      identified as the dominant positive driver. Overall, our findings add novel 
      evidence that co-exposures to phthalates might be positively associated with RA 
      incidence. Given the limitations of the NHANES study, well-designed longitudinal 
      studies are required to verify or disprove these results.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Chen, Yuting
AU  - Chen Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; The Key 
      Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan 
      Road, Hefei, Anhui, 230032, China. Electronic address: chenyuting1110@163.com.
FAU - Shen, Jiran
AU  - Shen J
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, Anhui, 230032, China.
FAU - Wu, Ye
AU  - Wu Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; The Key 
      Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan 
      Road, Hefei, Anhui, 230032, China.
FAU - Fang, Lanlan
AU  - Fang L
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; The Key 
      Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan 
      Road, Hefei, Anhui, 230032, China.
FAU - Xu, Shanshan
AU  - Xu S
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; The Key 
      Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan 
      Road, Hefei, Anhui, 230032, China.
FAU - Peng, Yongzhen
AU  - Peng Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; The Key 
      Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan 
      Road, Hefei, Anhui, 230032, China.
FAU - Pan, Faming
AU  - Pan F
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; The Key 
      Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan 
      Road, Hefei, Anhui, 230032, China. Electronic address: famingpan@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230630
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 6O7F7IX66E (phthalic acid)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phthalic Acids)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - *Environmental Pollutants/urine
MH  - *Phthalic Acids/metabolism
MH  - *Arthritis, Rheumatoid/epidemiology
MH  - Environmental Exposure
OTO - NOTNLM
OT  - Combined effect
OT  - NHANES
OT  - Phthalate
OT  - Rheumatoid arthritis
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/07/03 00:41
MHDA- 2023/07/24 06:42
CRDT- 2023/07/02 19:28
PHST- 2023/03/31 00:00 [received]
PHST- 2023/06/18 00:00 [revised]
PHST- 2023/06/29 00:00 [accepted]
PHST- 2023/07/24 06:42 [medline]
PHST- 2023/07/03 00:41 [pubmed]
PHST- 2023/07/02 19:28 [entrez]
AID - S0045-6535(23)01649-1 [pii]
AID - 10.1016/j.chemosphere.2023.139382 [doi]
PST - ppublish
SO  - Chemosphere. 2023 Oct;337:139382. doi: 10.1016/j.chemosphere.2023.139382. Epub 
      2023 Jun 30.