PMID- 37395234
OWN - NLM
STAT- MEDLINE
DCOM- 20230704
LR  - 20230901
IS  - 1473-5687 (Electronic)
IS  - 0954-691X (Linking)
VI  - 35
IP  - 8
DP  - 2023 Aug 1
TI  - The association between duration of and indications for proton pump inhibitor use 
      and risk of gastric polyps.
PG  - 829-835
LID - 10.1097/MEG.0000000000002587 [doi]
AB  - OBJECTIVES: The development of fundic gland polyps (FGPs) is the most common side 
      effect of long-term proton pump inhibitor (PPI) use; however, the effect of drug 
      use characteristics and their impact on the risk of other gastric polyp 
      development remain unclear. We aimed to identify the influence of PPI 
      administration, as well as its duration and dose, in the development of gastric 
      polyps. METHODS: A prospective cohort study was conducted on consecutive patients 
      who underwent gastroscopy between September 2017 and August 2019. Detailed 
      characteristics of gastric polyps, Helicobacter pylori infection, and PPI use 
      were analyzed. RESULTS: Among the 2723 patients included, gastric polyps (75% 
      FGPs, 22% hyperplastic) were detected in 16.4%, and 60% were prescribed PPI. The 
      risk of FGPs and hyperplastic polyps according to the duration of PPI use were as 
      follows: 2-5 years [odds ratio (95% confidence interval); 2.86 (2.00-4.11) and 
      2.82 (1.69-4.78)]; 6-9 years [7.42 (5.03-11.01) and 2.32 (1.05-4.78)]; >/=10 years 
      [14.94 (10.36-21.80) and 3.52 (1.67-7.03)]. Multivariate analysis confirmed that 
      the risk of FGPs was 17.16 (11.35-26.23) for >/=10 years of PPI use. Portal 
      hypertension-related conditions were associated with hyperplastic polyps [4.99 
      (2.71-9.20)]. CONCLUSION: Duration of and indications for PPI use are the most 
      predictive factors for the development of gastric polyps. Prolonged PPI use 
      increases the risk of polyp development and the number of patients with polyps, 
      which may burden endoscopic practice. Highly selected patients may require 
      particular care despite minimal risk of dysplasia and bleeding generally.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Kroupa, Radek
AU  - Kroupa R
AD  - Department of Internal Medicine and Gastroenterology, University Hospital Brno.
FAU - Pavlik, Tomas
AU  - Pavlik T
AD  - Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 
      Brno.
AD  - Institute of Health Information and Statistics of the Czech Republic, Prague.
FAU - Konecny, Stefan
AU  - Konecny S
AD  - Department of Internal Medicine and Gastroenterology, University Hospital Brno.
FAU - Packova, Barbora
AU  - Packova B
AD  - Department of Internal Medicine and Gastroenterology, University Hospital Brno.
FAU - Dastych, Milan
AU  - Dastych M
AD  - Department of Internal Medicine and Gastroenterology, University Hospital Brno.
FAU - Pavlovsky, Zdenek
AU  - Pavlovsky Z
AD  - Department of Pathology, University Hospital Brno, Faculty of Medicine, Masaryk 
      University, Brno, Czech Republic.
FAU - Dolina, Jiri
AU  - Dolina J
AD  - Department of Internal Medicine and Gastroenterology, University Hospital Brno.
LA  - eng
PT  - Journal Article
DEP - 20230606
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (Proton Pump Inhibitors)
RN  - Polyposis Of Gastric Fundus Without Polyposis Coli
RN  - Polyposis, Gastric
SB  - IM
MH  - Humans
MH  - Proton Pump Inhibitors/adverse effects
MH  - *Helicobacter Infections/complications/drug therapy
MH  - Prospective Studies
MH  - *Helicobacter pylori
MH  - *Stomach Neoplasms/chemically induced/epidemiology/complications
MH  - *Polyps/chemically induced/epidemiology/complications
MH  - Gastroscopy
EDAT- 2023/07/03 06:42
MHDA- 2023/07/04 06:42
CRDT- 2023/07/03 05:52
PHST- 2023/07/04 06:42 [medline]
PHST- 2023/07/03 06:42 [pubmed]
PHST- 2023/07/03 05:52 [entrez]
AID - 00042737-202308000-00005 [pii]
AID - 10.1097/MEG.0000000000002587 [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2023 Aug 1;35(8):829-835. doi: 
      10.1097/MEG.0000000000002587. Epub 2023 Jun 6.